ID   Y2298_MYCTO             Reviewed;         323 AA.
AC   P9WQA6; L0T9E3; P63484; Q50668;
DT   16-APR-2014, integrated into UniProtKB/Swiss-Prot.
DT   16-APR-2014, sequence version 1.
DT   03-AUG-2022, entry version 33.
DE   RecName: Full=Uncharacterized oxidoreductase MT2355;
DE            EC=1.-.-.-;
GN   OrderedLocusNames=MT2355;
OS   Mycobacterium tuberculosis (strain CDC 1551 / Oshkosh).
OC   Bacteria; Actinobacteria; Corynebacteriales; Mycobacteriaceae;
OC   Mycobacterium; Mycobacterium tuberculosis complex.
OX   NCBI_TaxID=83331;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=CDC 1551 / Oshkosh;
RX   PubMed=12218036; DOI=10.1128/jb.184.19.5479-5490.2002;
RA   Fleischmann R.D., Alland D., Eisen J.A., Carpenter L., White O.,
RA   Peterson J.D., DeBoy R.T., Dodson R.J., Gwinn M.L., Haft D.H., Hickey E.K.,
RA   Kolonay J.F., Nelson W.C., Umayam L.A., Ermolaeva M.D., Salzberg S.L.,
RA   Delcher A., Utterback T.R., Weidman J.F., Khouri H.M., Gill J., Mikula A.,
RA   Bishai W., Jacobs W.R. Jr., Venter J.C., Fraser C.M.;
RT   "Whole-genome comparison of Mycobacterium tuberculosis clinical and
RT   laboratory strains.";
RL   J. Bacteriol. 184:5479-5490(2002).
CC   -!- SIMILARITY: Belongs to the aldo/keto reductase family. Aldo/keto
CC       reductase 2 subfamily. {ECO:0000305}.
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DR   EMBL; AE000516; AAK46640.1; -; Genomic_DNA.
DR   PIR; F70733; F70733.
DR   RefSeq; WP_003902161.1; NZ_KK341227.1.
DR   AlphaFoldDB; P9WQA6; -.
DR   SMR; P9WQA6; -.
DR   EnsemblBacteria; AAK46640; AAK46640; MT2355.
DR   GeneID; 45426278; -.
DR   KEGG; mtc:MT2355; -.
DR   PATRIC; fig|83331.31.peg.2535; -.
DR   HOGENOM; CLU_023205_2_3_11; -.
DR   Proteomes; UP000001020; Chromosome.
DR   GO; GO:0016491; F:oxidoreductase activity; IEA:UniProtKB-KW.
DR   Gene3D; 3.20.20.100; -; 1.
DR   InterPro; IPR023210; NADP_OxRdtase_dom.
DR   InterPro; IPR036812; NADP_OxRdtase_dom_sf.
DR   Pfam; PF00248; Aldo_ket_red; 1.
DR   SUPFAM; SSF51430; SSF51430; 1.
PE   3: Inferred from homology;
KW   NADP; Oxidoreductase.
FT   CHAIN           1..323
FT                   /note="Uncharacterized oxidoreductase MT2355"
FT                   /id="PRO_0000426809"
FT   ACT_SITE        59
FT                   /note="Proton donor"
FT                   /evidence="ECO:0000250"
FT   BINDING         198..208
FT                   /ligand="NADP(+)"
FT                   /ligand_id="ChEBI:CHEBI:58349"
FT                   /evidence="ECO:0000250"
SQ   SEQUENCE   323 AA;  34986 MW;  FF071A48B745B8E8 CRC64;
     MKYLDVDGIG QVSRIGLGTW QFGSREWGYG DRYATGAARD IVKRARALGV TLFDTAEIYG
     LGKSERILGE ALGDDRTEVV VASKVFPVAP FPAVIKNRER ASARRLQLNR IPLYQIHQPN
     PVVPDSVIMP GMRDLLDSGD IGAAGVSNYS LARWRKADAA LGRPVVSNQV HFSLAHPDAL
     EDLVPFAELE NRIVIAYSPL AQGLLGGKYG LENRPGGVRA LNPLFGTENL RRIEPLLATL
     RAIAVDVDAK PAQVALAWLI SLPGVVAIPG ASSVEQLEFN VAAADIELSA QSRDALTDAA
     RAFRPVSTGR FLTDMVREKV SRR