ID   Y2298_MYCTU             Reviewed;         323 AA.
AC   P9WQA7; L0T9E3; P63484; Q50668;
DT   16-APR-2014, integrated into UniProtKB/Swiss-Prot.
DT   16-APR-2014, sequence version 1.
DT   03-AUG-2022, entry version 36.
DE   RecName: Full=Uncharacterized oxidoreductase Rv2298;
DE            EC=1.-.-.-;
GN   OrderedLocusNames=Rv2298; ORFNames=MTCY339.12c;
OS   Mycobacterium tuberculosis (strain ATCC 25618 / H37Rv).
OC   Bacteria; Actinobacteria; Corynebacteriales; Mycobacteriaceae;
OC   Mycobacterium; Mycobacterium tuberculosis complex.
OX   NCBI_TaxID=83332;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=ATCC 25618 / H37Rv;
RX   PubMed=9634230; DOI=10.1038/31159;
RA   Cole S.T., Brosch R., Parkhill J., Garnier T., Churcher C.M., Harris D.E.,
RA   Gordon S.V., Eiglmeier K., Gas S., Barry C.E. III, Tekaia F., Badcock K.,
RA   Basham D., Brown D., Chillingworth T., Connor R., Davies R.M., Devlin K.,
RA   Feltwell T., Gentles S., Hamlin N., Holroyd S., Hornsby T., Jagels K.,
RA   Krogh A., McLean J., Moule S., Murphy L.D., Oliver S., Osborne J.,
RA   Quail M.A., Rajandream M.A., Rogers J., Rutter S., Seeger K., Skelton S.,
RA   Squares S., Squares R., Sulston J.E., Taylor K., Whitehead S.,
RA   Barrell B.G.;
RT   "Deciphering the biology of Mycobacterium tuberculosis from the complete
RT   genome sequence.";
RL   Nature 393:537-544(1998).
RN   [2]
RP   IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
RC   STRAIN=ATCC 25618 / H37Rv;
RX   PubMed=21969609; DOI=10.1074/mcp.m111.011627;
RA   Kelkar D.S., Kumar D., Kumar P., Balakrishnan L., Muthusamy B., Yadav A.K.,
RA   Shrivastava P., Marimuthu A., Anand S., Sundaram H., Kingsbury R.,
RA   Harsha H.C., Nair B., Prasad T.S., Chauhan D.S., Katoch K., Katoch V.M.,
RA   Kumar P., Chaerkady R., Ramachandran S., Dash D., Pandey A.;
RT   "Proteogenomic analysis of Mycobacterium tuberculosis by high resolution
RT   mass spectrometry.";
RL   Mol. Cell. Proteomics 10:M111.011627-M111.011627(2011).
CC   -!- SIMILARITY: Belongs to the aldo/keto reductase family. Aldo/keto
CC       reductase 2 subfamily. {ECO:0000305}.
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DR   EMBL; AL123456; CCP45080.1; -; Genomic_DNA.
DR   PIR; F70733; F70733.
DR   RefSeq; NP_216814.1; NC_000962.3.
DR   RefSeq; WP_003902161.1; NZ_NVQJ01000012.1.
DR   AlphaFoldDB; P9WQA7; -.
DR   SMR; P9WQA7; -.
DR   STRING; 83332.Rv2298; -.
DR   PaxDb; P9WQA7; -.
DR   DNASU; 887344; -.
DR   GeneID; 45426278; -.
DR   GeneID; 887344; -.
DR   KEGG; mtu:Rv2298; -.
DR   TubercuList; Rv2298; -.
DR   eggNOG; COG0667; Bacteria.
DR   OMA; CGTWAWG; -.
DR   PhylomeDB; P9WQA7; -.
DR   Proteomes; UP000001584; Chromosome.
DR   GO; GO:0005737; C:cytoplasm; IBA:GO_Central.
DR   GO; GO:0009274; C:peptidoglycan-based cell wall; HDA:MTBBASE.
DR   GO; GO:0005886; C:plasma membrane; HDA:MTBBASE.
DR   GO; GO:0004033; F:aldo-keto reductase (NADP) activity; IBA:GO_Central.
DR   Gene3D; 3.20.20.100; -; 1.
DR   InterPro; IPR023210; NADP_OxRdtase_dom.
DR   InterPro; IPR036812; NADP_OxRdtase_dom_sf.
DR   Pfam; PF00248; Aldo_ket_red; 1.
DR   SUPFAM; SSF51430; SSF51430; 1.
PE   1: Evidence at protein level;
KW   NADP; Oxidoreductase; Reference proteome.
FT   CHAIN           1..323
FT                   /note="Uncharacterized oxidoreductase Rv2298"
FT                   /id="PRO_0000070396"
FT   ACT_SITE        59
FT                   /note="Proton donor"
FT                   /evidence="ECO:0000250"
FT   BINDING         198..208
FT                   /ligand="NADP(+)"
FT                   /ligand_id="ChEBI:CHEBI:58349"
FT                   /evidence="ECO:0000250"
SQ   SEQUENCE   323 AA;  34986 MW;  FF071A48B745B8E8 CRC64;
     MKYLDVDGIG QVSRIGLGTW QFGSREWGYG DRYATGAARD IVKRARALGV TLFDTAEIYG
     LGKSERILGE ALGDDRTEVV VASKVFPVAP FPAVIKNRER ASARRLQLNR IPLYQIHQPN
     PVVPDSVIMP GMRDLLDSGD IGAAGVSNYS LARWRKADAA LGRPVVSNQV HFSLAHPDAL
     EDLVPFAELE NRIVIAYSPL AQGLLGGKYG LENRPGGVRA LNPLFGTENL RRIEPLLATL
     RAIAVDVDAK PAQVALAWLI SLPGVVAIPG ASSVEQLEFN VAAADIELSA QSRDALTDAA
     RAFRPVSTGR FLTDMVREKV SRR