ID   Y229_SYNY3              Reviewed;         290 AA.
AC   Q55702;
DT   15-JUL-1998, integrated into UniProtKB/Swiss-Prot.
DT   01-NOV-1996, sequence version 1.
DT   03-AUG-2022, entry version 126.
DE   RecName: Full=Uncharacterized oxidoreductase slr0229;
DE            EC=1.1.-.-;
GN   OrderedLocusNames=slr0229;
OS   Synechocystis sp. (strain PCC 6803 / Kazusa).
OC   Bacteria; Cyanobacteria; Synechococcales; Merismopediaceae; Synechocystis;
OC   unclassified Synechocystis.
OX   NCBI_TaxID=1111708;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=ATCC 27184 / PCC 6803 / N-1;
RX   PubMed=8590279; DOI=10.1093/dnares/2.4.153;
RA   Kaneko T., Tanaka A., Sato S., Kotani H., Sazuka T., Miyajima N.,
RA   Sugiura M., Tabata S.;
RT   "Sequence analysis of the genome of the unicellular cyanobacterium
RT   Synechocystis sp. strain PCC6803. I. Sequence features in the 1 Mb region
RT   from map positions 64% to 92% of the genome.";
RL   DNA Res. 2:153-166(1995).
RN   [2]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=PCC 6803 / Kazusa;
RX   PubMed=8905231; DOI=10.1093/dnares/3.3.109;
RA   Kaneko T., Sato S., Kotani H., Tanaka A., Asamizu E., Nakamura Y.,
RA   Miyajima N., Hirosawa M., Sugiura M., Sasamoto S., Kimura T., Hosouchi T.,
RA   Matsuno A., Muraki A., Nakazaki N., Naruo K., Okumura S., Shimpo S.,
RA   Takeuchi C., Wada T., Watanabe A., Yamada M., Yasuda M., Tabata S.;
RT   "Sequence analysis of the genome of the unicellular cyanobacterium
RT   Synechocystis sp. strain PCC6803. II. Sequence determination of the entire
RT   genome and assignment of potential protein-coding regions.";
RL   DNA Res. 3:109-136(1996).
CC   -!- SIMILARITY: Belongs to the HIBADH-related family. {ECO:0000305}.
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DR   EMBL; BA000022; BAA10233.1; -; Genomic_DNA.
DR   PIR; S76381; S76381.
DR   AlphaFoldDB; Q55702; -.
DR   SMR; Q55702; -.
DR   IntAct; Q55702; 2.
DR   STRING; 1148.1001605; -.
DR   PaxDb; Q55702; -.
DR   EnsemblBacteria; BAA10233; BAA10233; BAA10233.
DR   KEGG; syn:slr0229; -.
DR   eggNOG; COG2084; Bacteria.
DR   InParanoid; Q55702; -.
DR   OMA; WSSEVNN; -.
DR   PhylomeDB; Q55702; -.
DR   Proteomes; UP000001425; Chromosome.
DR   GO; GO:0051287; F:NAD binding; IEA:InterPro.
DR   GO; GO:0050661; F:NADP binding; IEA:InterPro.
DR   GO; GO:0016491; F:oxidoreductase activity; IEA:UniProtKB-KW.
DR   GO; GO:0016054; P:organic acid catabolic process; IEA:UniProt.
DR   Gene3D; 1.10.1040.10; -; 1.
DR   InterPro; IPR002204; 3-OH-isobutyrate_DH-rel_CS.
DR   InterPro; IPR008927; 6-PGluconate_DH-like_C_sf.
DR   InterPro; IPR013328; 6PGD_dom2.
DR   InterPro; IPR006115; 6PGDH_NADP-bd.
DR   InterPro; IPR015815; HIBADH-related.
DR   InterPro; IPR036291; NAD(P)-bd_dom_sf.
DR   InterPro; IPR029154; NADP-bd.
DR   Pfam; PF14833; NAD_binding_11; 1.
DR   Pfam; PF03446; NAD_binding_2; 1.
DR   PIRSF; PIRSF000103; HIBADH; 1.
DR   SUPFAM; SSF48179; SSF48179; 1.
DR   SUPFAM; SSF51735; SSF51735; 1.
DR   PROSITE; PS00895; 3_HYDROXYISOBUT_DH; 1.
PE   3: Inferred from homology;
KW   NAD; Oxidoreductase; Reference proteome.
FT   CHAIN           1..290
FT                   /note="Uncharacterized oxidoreductase slr0229"
FT                   /id="PRO_0000173070"
FT   ACT_SITE        175
FT                   /evidence="ECO:0000250"
FT   BINDING         7..21
FT                   /ligand="NAD(+)"
FT                   /ligand_id="ChEBI:CHEBI:57540"
FT                   /evidence="ECO:0000250"
FT   BINDING         100
FT                   /ligand="NAD(+)"
FT                   /ligand_id="ChEBI:CHEBI:57540"
FT                   /evidence="ECO:0000250"
FT   BINDING         243
FT                   /ligand="NAD(+)"
FT                   /ligand_id="ChEBI:CHEBI:57540"
FT                   /evidence="ECO:0000250"
SQ   SEQUENCE   290 AA;  29930 MW;  BB167CD4FCF4A37A CRC64;
     MNVSKIAVFG LGVMGSPMAQ NLVKNGYQTV GYNRTLERPS VQEAAKAGVK VVTSIAVAAA
     NADIILTCVG DEKDVQQLIL GSGGIAEYAK PQALIIDCST IGKTAAYELA TNLKLQGLRF
     LDAPVTGGDV GAINGTLTIM VGGDISDFEE ALPVLKSIGE KIVHCGPSGS GQAVKLCNQV
     LCGIHAIAAA EAIQLSEQLG IAPELVIDTC GSGAAGSWAL TNLAPKMSEA DFAPGFMVKH
     LLKDLRLVRE AAENGPLPGV TLAESLFTSV QLLGGEDQGS QAIIRAYREA