ID   Y2303_MYCBO             Reviewed;         312 AA.
AC   P67668; A0A1R3Y1I7; Q50683; X2BKM0;
DT   11-OCT-2004, integrated into UniProtKB/Swiss-Prot.
DT   11-OCT-2004, sequence version 1.
DT   25-MAY-2022, entry version 97.
DE   RecName: Full=Uncharacterized HTH-type transcriptional regulator Mb2303c;
GN   OrderedLocusNames=BQ2027_MB2303C;
OS   Mycobacterium bovis (strain ATCC BAA-935 / AF2122/97).
OC   Bacteria; Actinobacteria; Corynebacteriales; Mycobacteriaceae;
OC   Mycobacterium; Mycobacterium tuberculosis complex.
OX   NCBI_TaxID=233413;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=ATCC BAA-935 / AF2122/97;
RX   PubMed=12788972; DOI=10.1073/pnas.1130426100;
RA   Garnier T., Eiglmeier K., Camus J.-C., Medina N., Mansoor H., Pryor M.,
RA   Duthoy S., Grondin S., Lacroix C., Monsempe C., Simon S., Harris B.,
RA   Atkin R., Doggett J., Mayes R., Keating L., Wheeler P.R., Parkhill J.,
RA   Barrell B.G., Cole S.T., Gordon S.V., Hewinson R.G.;
RT   "The complete genome sequence of Mycobacterium bovis.";
RL   Proc. Natl. Acad. Sci. U.S.A. 100:7877-7882(2003).
RN   [2]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA], AND GENOME REANNOTATION.
RC   STRAIN=ATCC BAA-935 / AF2122/97;
RX   PubMed=28385856; DOI=10.1128/genomea.00157-17;
RA   Malone K.M., Farrell D., Stuber T.P., Schubert O.T., Aebersold R.,
RA   Robbe-Austerman S., Gordon S.V.;
RT   "Updated reference genome sequence and annotation of Mycobacterium bovis
RT   AF2122/97.";
RL   Genome Announc. 5:E00157-E00157(2017).
CC   -!- SIMILARITY: Belongs to the LysR transcriptional regulatory family.
CC       {ECO:0000305}.
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DR   EMBL; LT708304; SIU00915.1; -; Genomic_DNA.
DR   RefSeq; NP_855952.1; NC_002945.3.
DR   RefSeq; WP_003411696.1; NC_002945.4.
DR   AlphaFoldDB; P67668; -.
DR   SMR; P67668; -.
DR   EnsemblBacteria; SIU00915; SIU00915; BQ2027_MB2303C.
DR   PATRIC; fig|233413.5.peg.2528; -.
DR   OMA; IEGPCHH; -.
DR   Proteomes; UP000001419; Chromosome.
DR   GO; GO:0003677; F:DNA binding; IEA:UniProtKB-KW.
DR   GO; GO:0003700; F:DNA-binding transcription factor activity; IEA:InterPro.
DR   Gene3D; 1.10.10.10; -; 1.
DR   InterPro; IPR005119; LysR_subst-bd.
DR   InterPro; IPR000847; Tscrpt_reg_HTH_LysR.
DR   InterPro; IPR036388; WH-like_DNA-bd_sf.
DR   InterPro; IPR036390; WH_DNA-bd_sf.
DR   Pfam; PF00126; HTH_1; 1.
DR   Pfam; PF03466; LysR_substrate; 1.
DR   SUPFAM; SSF46785; SSF46785; 1.
DR   PROSITE; PS50931; HTH_LYSR; 1.
PE   3: Inferred from homology;
KW   DNA-binding; Transcription; Transcription regulation.
FT   CHAIN           1..312
FT                   /note="Uncharacterized HTH-type transcriptional regulator
FT                   Mb2303c"
FT                   /id="PRO_0000105815"
FT   DOMAIN          8..65
FT                   /note="HTH lysR-type"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00253"
FT   DNA_BIND        25..45
FT                   /note="H-T-H motif"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00253"
SQ   SEQUENCE   312 AA;  32989 MW;  FFD057C7CA4031F2 CRC64;
     MPLSSRMPGL TCFEIFLAIA EAGSLGGAAR ELGLTQQAVS RRLASMEAQI GVRLAIRTTR
     GSQLTPAGIV VAEWAARLLE VADEIDAGLG SLRTEGRQRI RVVASQTIAE QLMPHWMLSL
     RAADMRRGGT VPEVILTATN SEHAIAAVRD GIADLGFIEN PCPPTGLGSV VVARDELVVV
     VPPGHKWARR SRVVSARELA QTPLVTREPN SGIRDSLTAA LRDTLGEDMQ QAPPVLELSS
     AAAVRAAVLA GAGPAAMSRL AIADDLAFGR LLAVDIPALN LRRQLRAIWV GGRTPPAGAI
     RDLLSHITSR ST