ID   Y2307_MYCTU             Reviewed;         281 AA.
AC   P9WLC7; L0T9F3; Q50658;
DT   16-APR-2014, integrated into UniProtKB/Swiss-Prot.
DT   16-APR-2014, sequence version 1.
DT   03-AUG-2022, entry version 41.
DE   RecName: Full=Uncharacterized protein Rv2307c;
GN   OrderedLocusNames=Rv2307c; ORFNames=MTCY339.02;
OS   Mycobacterium tuberculosis (strain ATCC 25618 / H37Rv).
OC   Bacteria; Actinobacteria; Corynebacteriales; Mycobacteriaceae;
OC   Mycobacterium; Mycobacterium tuberculosis complex.
OX   NCBI_TaxID=83332;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=ATCC 25618 / H37Rv;
RX   PubMed=9634230; DOI=10.1038/31159;
RA   Cole S.T., Brosch R., Parkhill J., Garnier T., Churcher C.M., Harris D.E.,
RA   Gordon S.V., Eiglmeier K., Gas S., Barry C.E. III, Tekaia F., Badcock K.,
RA   Basham D., Brown D., Chillingworth T., Connor R., Davies R.M., Devlin K.,
RA   Feltwell T., Gentles S., Hamlin N., Holroyd S., Hornsby T., Jagels K.,
RA   Krogh A., McLean J., Moule S., Murphy L.D., Oliver S., Osborne J.,
RA   Quail M.A., Rajandream M.A., Rogers J., Rutter S., Seeger K., Skelton S.,
RA   Squares S., Squares R., Sulston J.E., Taylor K., Whitehead S.,
RA   Barrell B.G.;
RT   "Deciphering the biology of Mycobacterium tuberculosis from the complete
RT   genome sequence.";
RL   Nature 393:537-544(1998).
RN   [2]
RP   IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
RC   STRAIN=ATCC 25618 / H37Rv;
RX   PubMed=21969609; DOI=10.1074/mcp.m111.011627;
RA   Kelkar D.S., Kumar D., Kumar P., Balakrishnan L., Muthusamy B., Yadav A.K.,
RA   Shrivastava P., Marimuthu A., Anand S., Sundaram H., Kingsbury R.,
RA   Harsha H.C., Nair B., Prasad T.S., Chauhan D.S., Katoch K., Katoch V.M.,
RA   Kumar P., Chaerkady R., Ramachandran S., Dash D., Pandey A.;
RT   "Proteogenomic analysis of Mycobacterium tuberculosis by high resolution
RT   mass spectrometry.";
RL   Mol. Cell. Proteomics 10:M111.011627-M111.011627(2011).
CC   -!- SUBCELLULAR LOCATION: Cell membrane {ECO:0000305}; Multi-pass membrane
CC       protein {ECO:0000305}.
CC   -!- SIMILARITY: To S.pombe bem46 and yeast YNL320w. {ECO:0000305}.
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DR   EMBL; AL123456; CCP45090.1; -; Genomic_DNA.
DR   PIR; G70734; G70734.
DR   RefSeq; NP_216823.1; NC_000962.3.
DR   RefSeq; WP_003906792.1; NZ_NVQJ01000012.1.
DR   AlphaFoldDB; P9WLC7; -.
DR   SMR; P9WLC7; -.
DR   STRING; 83332.Rv2307c; -.
DR   ESTHER; myctu-Y2307; ABHD13-BEM46.
DR   PaxDb; P9WLC7; -.
DR   DNASU; 885277; -.
DR   GeneID; 885277; -.
DR   KEGG; mtu:Rv2307c; -.
DR   TubercuList; Rv2307c; -.
DR   eggNOG; COG1073; Bacteria.
DR   OMA; PNGGHND; -.
DR   PhylomeDB; P9WLC7; -.
DR   Proteomes; UP000001584; Chromosome.
DR   GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR   GO; GO:0009274; C:peptidoglycan-based cell wall; HDA:MTBBASE.
DR   GO; GO:0005886; C:plasma membrane; IEA:UniProtKB-SubCell.
DR   GO; GO:0052562; P:suppression by symbiont of host immune response; IDA:MTBBASE.
DR   Gene3D; 3.40.50.1820; -; 1.
DR   InterPro; IPR029058; AB_hydrolase.
DR   InterPro; IPR022742; Hydrolase_4.
DR   Pfam; PF12146; Hydrolase_4; 1.
DR   SUPFAM; SSF53474; SSF53474; 1.
PE   1: Evidence at protein level;
KW   Cell membrane; Membrane; Reference proteome; Transmembrane;
KW   Transmembrane helix.
FT   CHAIN           1..281
FT                   /note="Uncharacterized protein Rv2307c"
FT                   /id="PRO_0000104016"
FT   TRANSMEM        8..28
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        97..117
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        147..167
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        210..230
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
SQ   SEQUENCE   281 AA;  29671 MW;  F586101519FC37D5 CRC64;
     MSLKRCRALP VVAIVALVAS GVIMFIWSQQ RRLIYFPSAG PVPSASSVLP AGRDVVVETQ
     DGMRLGGWYF PHTSGGSGPA VLVCNGNAGD RSMRAELAVA LHGLGLSVLL FDYRGYGGNP
     GRPSEQGLAA DARAAQEWLS GQSDVDPARI AYFGESLGAA VAVGLAVQRP PAALVLRSPF
     TSLAEVGAVH YPWLPLRRLL LDHYPSIERI ASVHAPVLVI AGGSDDIVPA TLSERLVAAA
     AEPKRYVVVP GVGHNDPELL DGRVMLDAIR RFLTETAVLG Q