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Y2319_MYCTU
ID   Y2319_MYCTU             Reviewed;         292 AA.
AC   P9WLB5; L0TC63; P64995; P71893;
DT   16-APR-2014, integrated into UniProtKB/Swiss-Prot.
DT   16-APR-2014, sequence version 1.
DT   25-MAY-2022, entry version 40.
DE   RecName: Full=Universal stress protein Rv2319c;
DE            Short=USP Rv2319c;
GN   OrderedLocusNames=Rv2319c; ORFNames=MTCY3G12.15;
OS   Mycobacterium tuberculosis (strain ATCC 25618 / H37Rv).
OC   Bacteria; Actinobacteria; Corynebacteriales; Mycobacteriaceae;
OC   Mycobacterium; Mycobacterium tuberculosis complex.
OX   NCBI_TaxID=83332;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=ATCC 25618 / H37Rv;
RX   PubMed=9634230; DOI=10.1038/31159;
RA   Cole S.T., Brosch R., Parkhill J., Garnier T., Churcher C.M., Harris D.E.,
RA   Gordon S.V., Eiglmeier K., Gas S., Barry C.E. III, Tekaia F., Badcock K.,
RA   Basham D., Brown D., Chillingworth T., Connor R., Davies R.M., Devlin K.,
RA   Feltwell T., Gentles S., Hamlin N., Holroyd S., Hornsby T., Jagels K.,
RA   Krogh A., McLean J., Moule S., Murphy L.D., Oliver S., Osborne J.,
RA   Quail M.A., Rajandream M.A., Rogers J., Rutter S., Seeger K., Skelton S.,
RA   Squares S., Squares R., Sulston J.E., Taylor K., Whitehead S.,
RA   Barrell B.G.;
RT   "Deciphering the biology of Mycobacterium tuberculosis from the complete
RT   genome sequence.";
RL   Nature 393:537-544(1998).
RN   [2]
RP   IDENTIFICATION AS A DRUG TARGET [LARGE SCALE ANALYSIS].
RX   PubMed=19099550; DOI=10.1186/1752-0509-2-109;
RA   Raman K., Yeturu K., Chandra N.;
RT   "targetTB: a target identification pipeline for Mycobacterium tuberculosis
RT   through an interactome, reactome and genome-scale structural analysis.";
RL   BMC Syst. Biol. 2:109-109(2008).
RN   [3]
RP   IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
RC   STRAIN=ATCC 25618 / H37Rv;
RX   PubMed=21969609; DOI=10.1074/mcp.m111.011627;
RA   Kelkar D.S., Kumar D., Kumar P., Balakrishnan L., Muthusamy B., Yadav A.K.,
RA   Shrivastava P., Marimuthu A., Anand S., Sundaram H., Kingsbury R.,
RA   Harsha H.C., Nair B., Prasad T.S., Chauhan D.S., Katoch K., Katoch V.M.,
RA   Kumar P., Chaerkady R., Ramachandran S., Dash D., Pandey A.;
RT   "Proteogenomic analysis of Mycobacterium tuberculosis by high resolution
RT   mass spectrometry.";
RL   Mol. Cell. Proteomics 10:M111.011627-M111.011627(2011).
CC   -!- MISCELLANEOUS: Was identified as a high-confidence drug target.
CC   -!- SIMILARITY: Belongs to the universal stress protein A family.
CC       {ECO:0000305}.
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DR   EMBL; AL123456; CCP45106.1; -; Genomic_DNA.
DR   PIR; H70703; H70703.
DR   RefSeq; NP_216835.1; NC_000962.3.
DR   RefSeq; WP_003411952.1; NZ_NVQJ01000012.1.
DR   AlphaFoldDB; P9WLB5; -.
DR   SMR; P9WLB5; -.
DR   STRING; 83332.Rv2319c; -.
DR   PaxDb; P9WLB5; -.
DR   DNASU; 885171; -.
DR   GeneID; 45426304; -.
DR   GeneID; 885171; -.
DR   KEGG; mtu:Rv2319c; -.
DR   TubercuList; Rv2319c; -.
DR   eggNOG; COG0589; Bacteria.
DR   OMA; PVPTMIV; -.
DR   Proteomes; UP000001584; Chromosome.
DR   InterPro; IPR006015; Universal_stress_UspA.
DR   InterPro; IPR006016; UspA.
DR   Pfam; PF00582; Usp; 2.
DR   PRINTS; PR01438; UNVRSLSTRESS.
PE   1: Evidence at protein level;
KW   Reference proteome.
FT   CHAIN           1..292
FT                   /note="Universal stress protein Rv2319c"
FT                   /id="PRO_0000104026"
SQ   SEQUENCE   292 AA;  31867 MW;  6F19B92293400CE2 CRC64;
     MTIVVGYLAG KVGPSALHLA VRVARMHKTS LTVATIVRRH WPTPSLARVD AEYELWSEQL
     AAASAREAQR YLRRLADGIE VSYHHRAHRS VSAGLLDVVE ELEAEVLVLG SFPSGRRARV
     LIGSTADRLL HSSPVPVAIT PRRYRCYTDR LTRLSCGYSA TSGSVDVVRR CGHLASRYGV
     PMRVITFAVR GRTMYPPEVG LHAEASVLEA WAAQARELLE KLRINGVVSE DVVLQVVTGN
     GWAQALDAAD WQDGEILALG TSPFGDVARV FLGSWSGKII RYSPVPVLVL PG
 
 
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