ID   Y2325_MYCTU             Reviewed;         282 AA.
AC   P9WPI7; L0TBZ8; P64997; P71887;
DT   16-APR-2014, integrated into UniProtKB/Swiss-Prot.
DT   16-APR-2014, sequence version 1.
DT   25-MAY-2022, entry version 34.
DE   RecName: Full=Uncharacterized protein Rv2325c;
GN   OrderedLocusNames=Rv2325c; ORFNames=MTCY3G12.09;
OS   Mycobacterium tuberculosis (strain ATCC 25618 / H37Rv).
OC   Bacteria; Actinobacteria; Corynebacteriales; Mycobacteriaceae;
OC   Mycobacterium; Mycobacterium tuberculosis complex.
OX   NCBI_TaxID=83332;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=ATCC 25618 / H37Rv;
RX   PubMed=9634230; DOI=10.1038/31159;
RA   Cole S.T., Brosch R., Parkhill J., Garnier T., Churcher C.M., Harris D.E.,
RA   Gordon S.V., Eiglmeier K., Gas S., Barry C.E. III, Tekaia F., Badcock K.,
RA   Basham D., Brown D., Chillingworth T., Connor R., Davies R.M., Devlin K.,
RA   Feltwell T., Gentles S., Hamlin N., Holroyd S., Hornsby T., Jagels K.,
RA   Krogh A., McLean J., Moule S., Murphy L.D., Oliver S., Osborne J.,
RA   Quail M.A., Rajandream M.A., Rogers J., Rutter S., Seeger K., Skelton S.,
RA   Squares S., Squares R., Sulston J.E., Taylor K., Whitehead S.,
RA   Barrell B.G.;
RT   "Deciphering the biology of Mycobacterium tuberculosis from the complete
RT   genome sequence.";
RL   Nature 393:537-544(1998).
RN   [2]
RP   IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
RC   STRAIN=ATCC 25618 / H37Rv;
RX   PubMed=21969609; DOI=10.1074/mcp.m111.011627;
RA   Kelkar D.S., Kumar D., Kumar P., Balakrishnan L., Muthusamy B., Yadav A.K.,
RA   Shrivastava P., Marimuthu A., Anand S., Sundaram H., Kingsbury R.,
RA   Harsha H.C., Nair B., Prasad T.S., Chauhan D.S., Katoch K., Katoch V.M.,
RA   Kumar P., Chaerkady R., Ramachandran S., Dash D., Pandey A.;
RT   "Proteogenomic analysis of Mycobacterium tuberculosis by high resolution
RT   mass spectrometry.";
RL   Mol. Cell. Proteomics 10:M111.011627-M111.011627(2011).
CC   -!- SUBCELLULAR LOCATION: Cell membrane {ECO:0000305}; Multi-pass membrane
CC       protein {ECO:0000305}.
CC   -!- SIMILARITY: Belongs to the CbiQ family. {ECO:0000305}.
CC   ---------------------------------------------------------------------------
CC   Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC   Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC   ---------------------------------------------------------------------------
DR   EMBL; AL123456; CCP45112.1; -; Genomic_DNA.
DR   PIR; F70704; F70704.
DR   RefSeq; NP_216841.1; NC_000962.3.
DR   RefSeq; WP_003411966.1; NZ_NVQJ01000012.1.
DR   AlphaFoldDB; P9WPI7; -.
DR   SMR; P9WPI7; -.
DR   STRING; 83332.Rv2325c; -.
DR   PaxDb; P9WPI7; -.
DR   DNASU; 886271; -.
DR   GeneID; 886271; -.
DR   KEGG; mtu:Rv2325c; -.
DR   TubercuList; Rv2325c; -.
DR   eggNOG; COG0619; Bacteria.
DR   OMA; PLRWLRI; -.
DR   PhylomeDB; P9WPI7; -.
DR   Proteomes; UP000001584; Chromosome.
DR   GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR   GO; GO:0005886; C:plasma membrane; HDA:MTBBASE.
DR   InterPro; IPR003339; ABC/ECF_trnsptr_transmembrane.
DR   Pfam; PF02361; CbiQ; 1.
PE   1: Evidence at protein level;
KW   Cell membrane; Membrane; Reference proteome; Transmembrane;
KW   Transmembrane helix.
FT   CHAIN           1..282
FT                   /note="Uncharacterized protein Rv2325c"
FT                   /id="PRO_0000104028"
FT   TRANSMEM        18..38
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        40..60
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        87..107
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        119..139
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        164..184
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        260..280
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
SQ   SEQUENCE   282 AA;  29956 MW;  689CDB75AA589D4E CRC64;
     MTTTSAPARN GTRRPSRPIV LLIPVPGSSV IHDLWAGTKL LVVFGISVLL TFYPGWVTIG
     MMAALVLAAA RIAHIPRGAL PSVPRWLWIV LAIGFLTAAL AGGTPVVAVG GVQLGLGGAL
     HFLRITALSV VLLALGAMVS WTTNVAEISP AVATLGRPFR VLRIPVDEWA VALALALRAF
     PMLIDEFQVL YAARRLRPKR MPPSRKARRQ RHARELIDLL AAAITVTLRR ADEMGDAITA
     RGGTGQLSAH PGRPKLADWV TLAITAMASG TAVAIESLIL HS