ID   Y2326_MYCTO             Reviewed;         697 AA.
AC   P9WQI6; L0TAW1; P63399; P71886;
DT   16-APR-2014, integrated into UniProtKB/Swiss-Prot.
DT   16-APR-2014, sequence version 1.
DT   03-AUG-2022, entry version 43.
DE   RecName: Full=Uncharacterized ABC transporter ATP-binding protein MT2388;
GN   OrderedLocusNames=MT2388;
OS   Mycobacterium tuberculosis (strain CDC 1551 / Oshkosh).
OC   Bacteria; Actinobacteria; Corynebacteriales; Mycobacteriaceae;
OC   Mycobacterium; Mycobacterium tuberculosis complex.
OX   NCBI_TaxID=83331;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=CDC 1551 / Oshkosh;
RX   PubMed=12218036; DOI=10.1128/jb.184.19.5479-5490.2002;
RA   Fleischmann R.D., Alland D., Eisen J.A., Carpenter L., White O.,
RA   Peterson J.D., DeBoy R.T., Dodson R.J., Gwinn M.L., Haft D.H., Hickey E.K.,
RA   Kolonay J.F., Nelson W.C., Umayam L.A., Ermolaeva M.D., Salzberg S.L.,
RA   Delcher A., Utterback T.R., Weidman J.F., Khouri H.M., Gill J., Mikula A.,
RA   Bishai W., Jacobs W.R. Jr., Venter J.C., Fraser C.M.;
RT   "Whole-genome comparison of Mycobacterium tuberculosis clinical and
RT   laboratory strains.";
RL   J. Bacteriol. 184:5479-5490(2002).
CC   -!- SUBCELLULAR LOCATION: Cell membrane {ECO:0000305}; Multi-pass membrane
CC       protein {ECO:0000305}.
CC   -!- SIMILARITY: Belongs to the ABC transporter superfamily. {ECO:0000305}.
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DR   EMBL; AE000516; AAK46680.1; -; Genomic_DNA.
DR   PIR; G70704; G70704.
DR   RefSeq; WP_003411969.1; NC_002755.2.
DR   AlphaFoldDB; P9WQI6; -.
DR   SMR; P9WQI6; -.
DR   EnsemblBacteria; AAK46680; AAK46680; MT2388.
DR   KEGG; mtc:MT2388; -.
DR   PATRIC; fig|83331.31.peg.2573; -.
DR   HOGENOM; CLU_000604_86_7_11; -.
DR   Proteomes; UP000001020; Chromosome.
DR   GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR   GO; GO:0005886; C:plasma membrane; IEA:UniProtKB-SubCell.
DR   GO; GO:0005524; F:ATP binding; IEA:UniProtKB-KW.
DR   GO; GO:0055085; P:transmembrane transport; IEA:InterPro.
DR   CDD; cd03225; ABC_cobalt_CbiO_domain1; 2.
DR   Gene3D; 3.40.50.300; -; 2.
DR   InterPro; IPR003593; AAA+_ATPase.
DR   InterPro; IPR003439; ABC_transporter-like_ATP-bd.
DR   InterPro; IPR017871; ABC_transporter-like_CS.
DR   InterPro; IPR015856; ABC_transpr_CbiO/EcfA_su.
DR   InterPro; IPR027417; P-loop_NTPase.
DR   Pfam; PF00005; ABC_tran; 2.
DR   SMART; SM00382; AAA; 2.
DR   SUPFAM; SSF52540; SSF52540; 2.
DR   PROSITE; PS00211; ABC_TRANSPORTER_1; 2.
DR   PROSITE; PS50893; ABC_TRANSPORTER_2; 2.
PE   3: Inferred from homology;
KW   ATP-binding; Cell membrane; Membrane; Nucleotide-binding; Repeat;
KW   Transmembrane; Transmembrane helix; Transport.
FT   CHAIN           1..697
FT                   /note="Uncharacterized ABC transporter ATP-binding protein
FT                   MT2388"
FT                   /id="PRO_0000426769"
FT   TRANSMEM        45..65
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        86..106
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        128..148
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        198..218
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        280..300
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        522..542
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   DOMAIN          251..473
FT                   /note="ABC transporter 1"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00434"
FT   DOMAIN          477..696
FT                   /note="ABC transporter 2"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00434"
FT   BINDING         285..292
FT                   /ligand="ATP"
FT                   /ligand_id="ChEBI:CHEBI:30616"
FT                   /ligand_label="1"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00434"
FT   BINDING         514..521
FT                   /ligand="ATP"
FT                   /ligand_id="ChEBI:CHEBI:30616"
FT                   /ligand_label="2"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00434"
SQ   SEQUENCE   697 AA;  72835 MW;  CB7759BE1E2F047E CRC64;
     MCCAVCGPEP GRIGEVTPLG PCPAQHRGGP LRPSELAQAS VMAALCAVTA IISVVVPFAA
     GLALLGTVPT GLLAYRYRLR VLAAATVAAG MIAFLIAGLG GFMGVVHSAY IGGLTGIVKR
     RGRGTPTVVV SSLIGGFVFG AAMVGMLAAM VRLRHLIFKV MTANVDGIAA TLARMHMQGA
     AADVKRYFAE GLQYWPWVLL GYFNIGIMIV SLIGWWALSR LLERMRGIPD VHKLDPPPGD
     DVDALIGPVP VRLDKVRFRY PRAGQDALRE VSLDVRAGEH LAIIGANGSG KTTLMLILAG
     RAPTSGTVDR PGTVGLGKLG GTAVVLQHPE SQVLGTRVAD DVVWGLPLGT TADVGRLLSE
     VGLEALAERD TGSLSGGELQ RLALAAALAR EPAMLIADEV TTMVDQQGRD ALLAVLSGLT
     QRHRTALVHI THYDNEADSA DRTLSLSDSP DNTDMVHTAA MPAPVIGVDQ PQHAPALELV
     GVGHEYASGT PWAKTALRDI NFVVEQGDGV LIHGGNGSGK STLAWIMAGL TIPTTGACLL
     DGRPTHEQVG AVALSFQAAR LQLMRSRVDL EVASAAGFSA SEQDRVAAAL TVVGLDPALG
     ARRIDQLSGG QMRRVVLAGL LARAPRALIL DEPLAGLDAA SQRGLLRLLE DLRRARGLTV
     VVVSHDFAGM EELCPRTLHL RDGVLESAAA SEAGGMS