Y2326_MYCTU
ID Y2326_MYCTU Reviewed; 697 AA.
AC P9WQI7; L0TAW1; P63399; P71886;
DT 16-APR-2014, integrated into UniProtKB/Swiss-Prot.
DT 16-APR-2014, sequence version 1.
DT 03-AUG-2022, entry version 45.
DE RecName: Full=Uncharacterized ABC transporter ATP-binding protein Rv2326c;
GN OrderedLocusNames=Rv2326c; ORFNames=MTCY3G12.08;
OS Mycobacterium tuberculosis (strain ATCC 25618 / H37Rv).
OC Bacteria; Actinobacteria; Corynebacteriales; Mycobacteriaceae;
OC Mycobacterium; Mycobacterium tuberculosis complex.
OX NCBI_TaxID=83332;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=ATCC 25618 / H37Rv;
RX PubMed=9634230; DOI=10.1038/31159;
RA Cole S.T., Brosch R., Parkhill J., Garnier T., Churcher C.M., Harris D.E.,
RA Gordon S.V., Eiglmeier K., Gas S., Barry C.E. III, Tekaia F., Badcock K.,
RA Basham D., Brown D., Chillingworth T., Connor R., Davies R.M., Devlin K.,
RA Feltwell T., Gentles S., Hamlin N., Holroyd S., Hornsby T., Jagels K.,
RA Krogh A., McLean J., Moule S., Murphy L.D., Oliver S., Osborne J.,
RA Quail M.A., Rajandream M.A., Rogers J., Rutter S., Seeger K., Skelton S.,
RA Squares S., Squares R., Sulston J.E., Taylor K., Whitehead S.,
RA Barrell B.G.;
RT "Deciphering the biology of Mycobacterium tuberculosis from the complete
RT genome sequence.";
RL Nature 393:537-544(1998).
RN [2]
RP IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
RC STRAIN=ATCC 25618 / H37Rv;
RX PubMed=21969609; DOI=10.1074/mcp.m111.011627;
RA Kelkar D.S., Kumar D., Kumar P., Balakrishnan L., Muthusamy B., Yadav A.K.,
RA Shrivastava P., Marimuthu A., Anand S., Sundaram H., Kingsbury R.,
RA Harsha H.C., Nair B., Prasad T.S., Chauhan D.S., Katoch K., Katoch V.M.,
RA Kumar P., Chaerkady R., Ramachandran S., Dash D., Pandey A.;
RT "Proteogenomic analysis of Mycobacterium tuberculosis by high resolution
RT mass spectrometry.";
RL Mol. Cell. Proteomics 10:M111.011627-M111.011627(2011).
CC -!- SUBCELLULAR LOCATION: Cell membrane {ECO:0000305}; Multi-pass membrane
CC protein {ECO:0000305}.
CC -!- SIMILARITY: Belongs to the ABC transporter superfamily. {ECO:0000305}.
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DR EMBL; AL123456; CCP45113.1; -; Genomic_DNA.
DR PIR; G70704; G70704.
DR RefSeq; NP_216842.1; NC_000962.3.
DR RefSeq; WP_003411969.1; NZ_NVQJ01000012.1.
DR AlphaFoldDB; P9WQI7; -.
DR SMR; P9WQI7; -.
DR STRING; 83332.Rv2326c; -.
DR PaxDb; P9WQI7; -.
DR DNASU; 888184; -.
DR GeneID; 888184; -.
DR KEGG; mtu:Rv2326c; -.
DR PATRIC; fig|83332.111.peg.2590; -.
DR TubercuList; Rv2326c; -.
DR eggNOG; COG1122; Bacteria.
DR OMA; SFISWSA; -.
DR PhylomeDB; P9WQI7; -.
DR Proteomes; UP000001584; Chromosome.
DR GO; GO:0043190; C:ATP-binding cassette (ABC) transporter complex; IBA:GO_Central.
DR GO; GO:0005887; C:integral component of plasma membrane; HDA:MTBBASE.
DR GO; GO:0009274; C:peptidoglycan-based cell wall; HDA:MTBBASE.
DR GO; GO:0005886; C:plasma membrane; HDA:MTBBASE.
DR GO; GO:0005524; F:ATP binding; IBA:GO_Central.
DR GO; GO:0042626; F:ATPase-coupled transmembrane transporter activity; IBA:GO_Central.
DR CDD; cd03225; ABC_cobalt_CbiO_domain1; 2.
DR Gene3D; 3.40.50.300; -; 2.
DR InterPro; IPR003593; AAA+_ATPase.
DR InterPro; IPR003439; ABC_transporter-like_ATP-bd.
DR InterPro; IPR017871; ABC_transporter-like_CS.
DR InterPro; IPR015856; ABC_transpr_CbiO/EcfA_su.
DR InterPro; IPR027417; P-loop_NTPase.
DR Pfam; PF00005; ABC_tran; 2.
DR SMART; SM00382; AAA; 2.
DR SUPFAM; SSF52540; SSF52540; 2.
DR PROSITE; PS00211; ABC_TRANSPORTER_1; 2.
DR PROSITE; PS50893; ABC_TRANSPORTER_2; 2.
PE 1: Evidence at protein level;
KW ATP-binding; Cell membrane; Membrane; Nucleotide-binding;
KW Reference proteome; Repeat; Transmembrane; Transmembrane helix; Transport.
FT CHAIN 1..697
FT /note="Uncharacterized ABC transporter ATP-binding protein
FT Rv2326c"
FT /id="PRO_0000093266"
FT TRANSMEM 45..65
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 86..106
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 128..148
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 198..218
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 280..300
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 522..542
FT /note="Helical"
FT /evidence="ECO:0000255"
FT DOMAIN 251..473
FT /note="ABC transporter 1"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00434"
FT DOMAIN 477..696
FT /note="ABC transporter 2"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00434"
FT BINDING 285..292
FT /ligand="ATP"
FT /ligand_id="ChEBI:CHEBI:30616"
FT /ligand_label="1"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00434"
FT BINDING 514..521
FT /ligand="ATP"
FT /ligand_id="ChEBI:CHEBI:30616"
FT /ligand_label="2"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00434"
SQ SEQUENCE 697 AA; 72835 MW; CB7759BE1E2F047E CRC64;
MCCAVCGPEP GRIGEVTPLG PCPAQHRGGP LRPSELAQAS VMAALCAVTA IISVVVPFAA
GLALLGTVPT GLLAYRYRLR VLAAATVAAG MIAFLIAGLG GFMGVVHSAY IGGLTGIVKR
RGRGTPTVVV SSLIGGFVFG AAMVGMLAAM VRLRHLIFKV MTANVDGIAA TLARMHMQGA
AADVKRYFAE GLQYWPWVLL GYFNIGIMIV SLIGWWALSR LLERMRGIPD VHKLDPPPGD
DVDALIGPVP VRLDKVRFRY PRAGQDALRE VSLDVRAGEH LAIIGANGSG KTTLMLILAG
RAPTSGTVDR PGTVGLGKLG GTAVVLQHPE SQVLGTRVAD DVVWGLPLGT TADVGRLLSE
VGLEALAERD TGSLSGGELQ RLALAAALAR EPAMLIADEV TTMVDQQGRD ALLAVLSGLT
QRHRTALVHI THYDNEADSA DRTLSLSDSP DNTDMVHTAA MPAPVIGVDQ PQHAPALELV
GVGHEYASGT PWAKTALRDI NFVVEQGDGV LIHGGNGSGK STLAWIMAGL TIPTTGACLL
DGRPTHEQVG AVALSFQAAR LQLMRSRVDL EVASAAGFSA SEQDRVAAAL TVVGLDPALG
ARRIDQLSGG QMRRVVLAGL LARAPRALIL DEPLAGLDAA SQRGLLRLLE DLRRARGLTV
VVVSHDFAGM EELCPRTLHL RDGVLESAAA SEAGGMS
