ID   Y2340_DICDI             Reviewed;         449 AA.
AC   Q86AY4; Q55A29;
DT   20-APR-2010, integrated into UniProtKB/Swiss-Prot.
DT   05-JUL-2004, sequence version 2.
DT   25-MAY-2022, entry version 92.
DE   RecName: Full=TNF receptor-associated factor family protein DDB_G0272340;
GN   ORFNames=DDB_G0272340;
OS   Dictyostelium discoideum (Slime mold).
OC   Eukaryota; Amoebozoa; Evosea; Eumycetozoa; Dictyostelia; Dictyosteliales;
OC   Dictyosteliaceae; Dictyostelium.
OX   NCBI_TaxID=44689;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=AX4;
RX   PubMed=12097910; DOI=10.1038/nature00847;
RA   Gloeckner G., Eichinger L., Szafranski K., Pachebat J.A., Bankier A.T.,
RA   Dear P.H., Lehmann R., Baumgart C., Parra G., Abril J.F., Guigo R.,
RA   Kumpf K., Tunggal B., Cox E.C., Quail M.A., Platzer M., Rosenthal A.,
RA   Noegel A.A.;
RT   "Sequence and analysis of chromosome 2 of Dictyostelium discoideum.";
RL   Nature 418:79-85(2002).
RN   [2]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=AX4;
RX   PubMed=15875012; DOI=10.1038/nature03481;
RA   Eichinger L., Pachebat J.A., Gloeckner G., Rajandream M.A., Sucgang R.,
RA   Berriman M., Song J., Olsen R., Szafranski K., Xu Q., Tunggal B.,
RA   Kummerfeld S., Madera M., Konfortov B.A., Rivero F., Bankier A.T.,
RA   Lehmann R., Hamlin N., Davies R., Gaudet P., Fey P., Pilcher K., Chen G.,
RA   Saunders D., Sodergren E.J., Davis P., Kerhornou A., Nie X., Hall N.,
RA   Anjard C., Hemphill L., Bason N., Farbrother P., Desany B., Just E.,
RA   Morio T., Rost R., Churcher C.M., Cooper J., Haydock S., van Driessche N.,
RA   Cronin A., Goodhead I., Muzny D.M., Mourier T., Pain A., Lu M., Harper D.,
RA   Lindsay R., Hauser H., James K.D., Quiles M., Madan Babu M., Saito T.,
RA   Buchrieser C., Wardroper A., Felder M., Thangavelu M., Johnson D.,
RA   Knights A., Loulseged H., Mungall K.L., Oliver K., Price C., Quail M.A.,
RA   Urushihara H., Hernandez J., Rabbinowitsch E., Steffen D., Sanders M.,
RA   Ma J., Kohara Y., Sharp S., Simmonds M.N., Spiegler S., Tivey A.,
RA   Sugano S., White B., Walker D., Woodward J.R., Winckler T., Tanaka Y.,
RA   Shaulsky G., Schleicher M., Weinstock G.M., Rosenthal A., Cox E.C.,
RA   Chisholm R.L., Gibbs R.A., Loomis W.F., Platzer M., Kay R.R.,
RA   Williams J.G., Dear P.H., Noegel A.A., Barrell B.G., Kuspa A.;
RT   "The genome of the social amoeba Dictyostelium discoideum.";
RL   Nature 435:43-57(2005).
CC   -!- FUNCTION: Probable adapter protein and signal transducer that links
CC       members of the tumor necrosis factor receptor family to different
CC       signaling pathways by association with the receptor cytoplasmic domain
CC       and kinases. {ECO:0000250}.
CC   -!- SUBCELLULAR LOCATION: Cytoplasm {ECO:0000250}.
CC   -!- DOMAIN: The MATH/TRAF domain binds to receptor cytoplasmic domains.
CC   -!- SIMILARITY: Belongs to the TNF receptor-associated factor family. A
CC       subfamily. {ECO:0000305}.
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DR   EMBL; AAFI02000008; EAL71322.1; -; Genomic_DNA.
DR   RefSeq; XP_645155.1; XM_640063.1.
DR   AlphaFoldDB; Q86AY4; -.
DR   SMR; Q86AY4; -.
DR   STRING; 44689.DDB0206573; -.
DR   PaxDb; Q86AY4; -.
DR   EnsemblProtists; EAL71322; EAL71322; DDB_G0272340.
DR   GeneID; 8618326; -.
DR   KEGG; ddi:DDB_G0272340; -.
DR   dictyBase; DDB_G0272340; trafG.
DR   eggNOG; KOG0297; Eukaryota.
DR   HOGENOM; CLU_040980_0_0_1; -.
DR   InParanoid; Q86AY4; -.
DR   OMA; ICEECIM; -.
DR   PhylomeDB; Q86AY4; -.
DR   Reactome; R-DDI-5689880; Ub-specific processing proteases.
DR   PRO; PR:Q86AY4; -.
DR   Proteomes; UP000002195; Chromosome 2.
DR   GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.
DR   GO; GO:0008270; F:zinc ion binding; IEA:InterPro.
DR   CDD; cd00121; MATH; 1.
DR   Gene3D; 2.60.210.10; -; 1.
DR   Gene3D; 3.30.40.10; -; 3.
DR   InterPro; IPR002083; MATH/TRAF_dom.
DR   InterPro; IPR043211; TNF_rcpt-assoc_TRAF.
DR   InterPro; IPR008974; TRAF-like.
DR   InterPro; IPR013083; Znf_RING/FYVE/PHD.
DR   InterPro; IPR001293; Znf_TRAF.
DR   PANTHER; PTHR10131; PTHR10131; 1.
DR   Pfam; PF00917; MATH; 1.
DR   Pfam; PF02176; zf-TRAF; 2.
DR   SMART; SM00061; MATH; 1.
DR   PROSITE; PS50144; MATH; 1.
DR   PROSITE; PS50145; ZF_TRAF; 2.
PE   3: Inferred from homology;
KW   Coiled coil; Cytoplasm; Metal-binding; Reference proteome; Repeat; Zinc;
KW   Zinc-finger.
FT   CHAIN           1..449
FT                   /note="TNF receptor-associated factor family protein
FT                   DDB_G0272340"
FT                   /id="PRO_0000393755"
FT   DOMAIN          311..437
FT                   /note="MATH"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00129"
FT   ZN_FING         33..76
FT                   /note="RING-type; degenerate"
FT   ZN_FING         133..187
FT                   /note="TRAF-type 1"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00207"
FT   ZN_FING         189..251
FT                   /note="TRAF-type 2"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00207"
FT   COILED          263..309
FT                   /evidence="ECO:0000255"
SQ   SEQUENCE   449 AA;  52883 MW;  024F73A99AB47A95 CRC64;
     MTTTISQLNI TPIKFTINDL IVDPVSLSEN FNCPICEECI MDVNKCEALQ CKEGHVHCRL
     CWMKSLESKK ECMTCRTRVN SVDSLSKNIY LQKEFRNKKI FCPNLFRILN SGKIEIDEKF
     GCKEILKVDE LEGHIKECQF QFIECPNDKE CKTRLRKNQL KDHAEKCKKL KSECEFCGEK
     GLVIDDSKVH YSECEKFPIK CPQNCNSPTF NCTIERGRIK YHIENECPFT VIQCKYREAG
     CMLEFPRSEL SEHMKLIDHS KYMEATIDQH ICKFEKSEKE YKKLELEYNR LKDDFKILQS
     ELKVIRELKF NYQNKWVITN WSQKLQDYPK PKSIESPEFM VGNLKFKIQF YPNGGLSDES
     KDFLSIYLYK FDDQTPSKVQ FSFELLNKDF TRNRKLASTN IFHTENKWGW RSFINNSLVT
     TQTGFVIQNS VTLNINIEIL PEEKEAFTS