ID   Y2345_MYCTO             Reviewed;         660 AA.
AC   P9WFJ4; L0TAY3; P95241; Q7D7A4;
DT   16-APR-2014, integrated into UniProtKB/Swiss-Prot.
DT   16-APR-2014, sequence version 1.
DT   25-MAY-2022, entry version 32.
DE   RecName: Full=UPF0603 protein MT2410;
DE   Flags: Precursor;
GN   OrderedLocusNames=MT2410;
OS   Mycobacterium tuberculosis (strain CDC 1551 / Oshkosh).
OC   Bacteria; Actinobacteria; Corynebacteriales; Mycobacteriaceae;
OC   Mycobacterium; Mycobacterium tuberculosis complex.
OX   NCBI_TaxID=83331;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=CDC 1551 / Oshkosh;
RX   PubMed=12218036; DOI=10.1128/jb.184.19.5479-5490.2002;
RA   Fleischmann R.D., Alland D., Eisen J.A., Carpenter L., White O.,
RA   Peterson J.D., DeBoy R.T., Dodson R.J., Gwinn M.L., Haft D.H., Hickey E.K.,
RA   Kolonay J.F., Nelson W.C., Umayam L.A., Ermolaeva M.D., Salzberg S.L.,
RA   Delcher A., Utterback T.R., Weidman J.F., Khouri H.M., Gill J., Mikula A.,
RA   Bishai W., Jacobs W.R. Jr., Venter J.C., Fraser C.M.;
RT   "Whole-genome comparison of Mycobacterium tuberculosis clinical and
RT   laboratory strains.";
RL   J. Bacteriol. 184:5479-5490(2002).
RN   [2]
RP   DISRUPTION PHENOTYPE.
RC   STRAIN=CDC 1551 / Oshkosh;
RX   PubMed=12775759; DOI=10.1073/pnas.1231432100;
RA   Lamichhane G., Zignol M., Blades N.J., Geiman D.E., Dougherty A.,
RA   Grosset J., Broman K.W., Bishai W.R.;
RT   "A postgenomic method for predicting essential genes at subsaturation
RT   levels of mutagenesis: application to Mycobacterium tuberculosis.";
RL   Proc. Natl. Acad. Sci. U.S.A. 100:7213-7218(2003).
CC   -!- FUNCTION: May play a role in septum formation. {ECO:0000250}.
CC   -!- SUBCELLULAR LOCATION: Cell membrane {ECO:0000305}; Multi-pass membrane
CC       protein {ECO:0000305}.
CC   -!- DISRUPTION PHENOTYPE: Not essential for growth.
CC       {ECO:0000269|PubMed:12775759}.
CC   -!- SIMILARITY: Belongs to the UPF0603 family. {ECO:0000305}.
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DR   EMBL; AE000516; AAK46703.1; -; Genomic_DNA.
DR   PIR; B70662; B70662.
DR   RefSeq; WP_003899282.1; NZ_KK341227.1.
DR   AlphaFoldDB; P9WFJ4; -.
DR   SMR; P9WFJ4; -.
DR   EnsemblBacteria; AAK46703; AAK46703; MT2410.
DR   KEGG; mtc:MT2410; -.
DR   PATRIC; fig|83331.31.peg.2598; -.
DR   HOGENOM; CLU_013689_1_0_11; -.
DR   Proteomes; UP000001020; Chromosome.
DR   GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR   GO; GO:0005886; C:plasma membrane; IEA:UniProtKB-SubCell.
DR   InterPro; IPR007621; TPM_dom.
DR   Pfam; PF04536; TPM_phosphatase; 1.
PE   3: Inferred from homology;
KW   Cell membrane; Coiled coil; Membrane; Signal; Transmembrane;
KW   Transmembrane helix.
FT   SIGNAL          1..26
FT                   /evidence="ECO:0000255"
FT   CHAIN           27..660
FT                   /note="UPF0603 protein MT2410"
FT                   /id="PRO_0000428528"
FT   TRANSMEM        162..182
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        605..625
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   REGION          638..660
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COILED          488..567
FT                   /evidence="ECO:0000255"
SQ   SEQUENCE   660 AA;  70030 MW;  1AD28D969F15EEFA CRC64;
     MRLVRLLGMV LTILAAGLLL GPPAGAQPPF RLSNYVTDNA GVLTSSGRTA VTAAVDRLYA
     DRRIRLWVVY VENFSGQSAL NWAQRTTRTS ELGNYDALLA VATTGREYAF LVPSAMPGVS
     EGQVDNVRRY QIEPALHDGD YSGAAVAAAN GLNRSPSSSS RVVLLVTVGI IVIVVAVLLV
     VMRHRNRRRR ADELAAARRV DPTNVMALAA VPLQALDDLS RSMVVDVDNA VRTSTNELAL
     AIEEFGERRT APFTQAVNNA KAALSQAFTV RQQLDDNTPE TPAQRRELLT RVIVSAAHAD
     RELASQTEAF EKLRDLVINA PARLDLLTQQ YVELTTRIGP TQQRLAELHT EFDAAAMTSI
     AGNVTTATER LAFADRNISA ARDLADQAVS GRQAGLVDAV RAAESALGQA RALLDAVDSA
     ATDIRHAVAS LPAVVADIQT GIKRANQHLQ QAQQPQTGRT GDLIAARDAA ARALDRARGA
     ADPLTAFDQL TKVDADLDRL LATLAEEQAT ADRLNRSLEQ ALFTAESRVR AVSEYIDTRR
     GSIGPEARTR LAEAKRQLEA AHDRKSSNPT EAIAYANAAS TLAAHAQSLA NADVQSAQRA
     YTRRGGNNAG AILGGIIIGD LLSGGTRGGL GGWIPTSFGG SSNAPGSSPD GGFLGGGGRF