ID   Y2345_MYCTU             Reviewed;         660 AA.
AC   P9WFJ5; L0TAY3; P95241; Q7D7A4;
DT   16-APR-2014, integrated into UniProtKB/Swiss-Prot.
DT   16-APR-2014, sequence version 1.
DT   03-AUG-2022, entry version 33.
DE   RecName: Full=UPF0603 protein Rv2345;
DE   Flags: Precursor;
GN   OrderedLocusNames=Rv2345;
OS   Mycobacterium tuberculosis (strain ATCC 25618 / H37Rv).
OC   Bacteria; Actinobacteria; Corynebacteriales; Mycobacteriaceae;
OC   Mycobacterium; Mycobacterium tuberculosis complex.
OX   NCBI_TaxID=83332;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=ATCC 25618 / H37Rv;
RX   PubMed=9634230; DOI=10.1038/31159;
RA   Cole S.T., Brosch R., Parkhill J., Garnier T., Churcher C.M., Harris D.E.,
RA   Gordon S.V., Eiglmeier K., Gas S., Barry C.E. III, Tekaia F., Badcock K.,
RA   Basham D., Brown D., Chillingworth T., Connor R., Davies R.M., Devlin K.,
RA   Feltwell T., Gentles S., Hamlin N., Holroyd S., Hornsby T., Jagels K.,
RA   Krogh A., McLean J., Moule S., Murphy L.D., Oliver S., Osborne J.,
RA   Quail M.A., Rajandream M.A., Rogers J., Rutter S., Seeger K., Skelton S.,
RA   Squares S., Squares R., Sulston J.E., Taylor K., Whitehead S.,
RA   Barrell B.G.;
RT   "Deciphering the biology of Mycobacterium tuberculosis from the complete
RT   genome sequence.";
RL   Nature 393:537-544(1998).
RN   [2]
RP   DISRUPTION PHENOTYPE.
RC   STRAIN=ATCC 25618 / H37Rv;
RX   PubMed=12657046; DOI=10.1046/j.1365-2958.2003.03425.x;
RA   Sassetti C.M., Boyd D.H., Rubin E.J.;
RT   "Genes required for mycobacterial growth defined by high density
RT   mutagenesis.";
RL   Mol. Microbiol. 48:77-84(2003).
RN   [3]
RP   INDUCTION, AND FUNCTION.
RC   STRAIN=ATCC 25618 / H37Rv;
RX   PubMed=16735741; DOI=10.1099/mic.0.28762-0;
RA   Slayden R.A., Knudson D.L., Belisle J.T.;
RT   "Identification of cell cycle regulators in Mycobacterium tuberculosis by
RT   inhibition of septum formation and global transcriptional analysis.";
RL   Microbiology 152:1789-1797(2006).
RN   [4]
RP   IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
RC   STRAIN=ATCC 25618 / H37Rv;
RX   PubMed=21969609; DOI=10.1074/mcp.m111.011627;
RA   Kelkar D.S., Kumar D., Kumar P., Balakrishnan L., Muthusamy B., Yadav A.K.,
RA   Shrivastava P., Marimuthu A., Anand S., Sundaram H., Kingsbury R.,
RA   Harsha H.C., Nair B., Prasad T.S., Chauhan D.S., Katoch K., Katoch V.M.,
RA   Kumar P., Chaerkady R., Ramachandran S., Dash D., Pandey A.;
RT   "Proteogenomic analysis of Mycobacterium tuberculosis by high resolution
RT   mass spectrometry.";
RL   Mol. Cell. Proteomics 10:M111.011627-M111.011627(2011).
CC   -!- FUNCTION: May play a role in septum formation.
CC       {ECO:0000269|PubMed:16735741}.
CC   -!- SUBCELLULAR LOCATION: Cell membrane {ECO:0000305}; Multi-pass membrane
CC       protein {ECO:0000305}.
CC   -!- INDUCTION: Induced by albendazole and thiabendazole, which inhibit the
CC       GTPase activity of FtsZ and probably septum formation.
CC       {ECO:0000269|PubMed:16735741}.
CC   -!- DISRUPTION PHENOTYPE: Not essential for growth.
CC       {ECO:0000269|PubMed:12657046}.
CC   -!- SIMILARITY: Belongs to the UPF0603 family. {ECO:0000305}.
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DR   EMBL; AL123456; CCP45133.1; -; Genomic_DNA.
DR   PIR; B70662; B70662.
DR   RefSeq; NP_216861.1; NC_000962.3.
DR   RefSeq; WP_003899282.1; NZ_NVQJ01000012.1.
DR   AlphaFoldDB; P9WFJ5; -.
DR   SMR; P9WFJ5; -.
DR   STRING; 83332.Rv2345; -.
DR   PaxDb; P9WFJ5; -.
DR   DNASU; 888960; -.
DR   GeneID; 888960; -.
DR   KEGG; mtu:Rv2345; -.
DR   TubercuList; Rv2345; -.
DR   eggNOG; COG1512; Bacteria.
DR   OMA; VRLWVVY; -.
DR   Proteomes; UP000001584; Chromosome.
DR   GO; GO:0005887; C:integral component of plasma membrane; HDA:MTBBASE.
DR   GO; GO:0009274; C:peptidoglycan-based cell wall; HDA:MTBBASE.
DR   GO; GO:0005886; C:plasma membrane; HDA:MTBBASE.
DR   InterPro; IPR007621; TPM_dom.
DR   Pfam; PF04536; TPM_phosphatase; 1.
PE   1: Evidence at protein level;
KW   Cell membrane; Coiled coil; Membrane; Reference proteome; Signal;
KW   Transmembrane; Transmembrane helix.
FT   SIGNAL          1..26
FT                   /evidence="ECO:0000255"
FT   CHAIN           27..660
FT                   /note="UPF0603 protein Rv2345"
FT                   /id="PRO_0000390675"
FT   TRANSMEM        162..182
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        605..625
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   REGION          638..660
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COILED          488..567
FT                   /evidence="ECO:0000255"
SQ   SEQUENCE   660 AA;  70030 MW;  1AD28D969F15EEFA CRC64;
     MRLVRLLGMV LTILAAGLLL GPPAGAQPPF RLSNYVTDNA GVLTSSGRTA VTAAVDRLYA
     DRRIRLWVVY VENFSGQSAL NWAQRTTRTS ELGNYDALLA VATTGREYAF LVPSAMPGVS
     EGQVDNVRRY QIEPALHDGD YSGAAVAAAN GLNRSPSSSS RVVLLVTVGI IVIVVAVLLV
     VMRHRNRRRR ADELAAARRV DPTNVMALAA VPLQALDDLS RSMVVDVDNA VRTSTNELAL
     AIEEFGERRT APFTQAVNNA KAALSQAFTV RQQLDDNTPE TPAQRRELLT RVIVSAAHAD
     RELASQTEAF EKLRDLVINA PARLDLLTQQ YVELTTRIGP TQQRLAELHT EFDAAAMTSI
     AGNVTTATER LAFADRNISA ARDLADQAVS GRQAGLVDAV RAAESALGQA RALLDAVDSA
     ATDIRHAVAS LPAVVADIQT GIKRANQHLQ QAQQPQTGRT GDLIAARDAA ARALDRARGA
     ADPLTAFDQL TKVDADLDRL LATLAEEQAT ADRLNRSLEQ ALFTAESRVR AVSEYIDTRR
     GSIGPEARTR LAEAKRQLEA AHDRKSSNPT EAIAYANAAS TLAAHAQSLA NADVQSAQRA
     YTRRGGNNAG AILGGIIIGD LLSGGTRGGL GGWIPTSFGG SSNAPGSSPD GGFLGGGGRF