Y2348_DICDI
ID Y2348_DICDI Reviewed; 595 AA.
AC Q86KX6; Q55A23;
DT 20-APR-2010, integrated into UniProtKB/Swiss-Prot.
DT 05-JUL-2004, sequence version 2.
DT 25-MAY-2022, entry version 89.
DE RecName: Full=TNF receptor-associated factor family protein DDB_G0272348;
GN ORFNames=DDB_G0272348;
OS Dictyostelium discoideum (Slime mold).
OC Eukaryota; Amoebozoa; Evosea; Eumycetozoa; Dictyostelia; Dictyosteliales;
OC Dictyosteliaceae; Dictyostelium.
OX NCBI_TaxID=44689;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=AX4;
RX PubMed=12097910; DOI=10.1038/nature00847;
RA Gloeckner G., Eichinger L., Szafranski K., Pachebat J.A., Bankier A.T.,
RA Dear P.H., Lehmann R., Baumgart C., Parra G., Abril J.F., Guigo R.,
RA Kumpf K., Tunggal B., Cox E.C., Quail M.A., Platzer M., Rosenthal A.,
RA Noegel A.A.;
RT "Sequence and analysis of chromosome 2 of Dictyostelium discoideum.";
RL Nature 418:79-85(2002).
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=AX4;
RX PubMed=15875012; DOI=10.1038/nature03481;
RA Eichinger L., Pachebat J.A., Gloeckner G., Rajandream M.A., Sucgang R.,
RA Berriman M., Song J., Olsen R., Szafranski K., Xu Q., Tunggal B.,
RA Kummerfeld S., Madera M., Konfortov B.A., Rivero F., Bankier A.T.,
RA Lehmann R., Hamlin N., Davies R., Gaudet P., Fey P., Pilcher K., Chen G.,
RA Saunders D., Sodergren E.J., Davis P., Kerhornou A., Nie X., Hall N.,
RA Anjard C., Hemphill L., Bason N., Farbrother P., Desany B., Just E.,
RA Morio T., Rost R., Churcher C.M., Cooper J., Haydock S., van Driessche N.,
RA Cronin A., Goodhead I., Muzny D.M., Mourier T., Pain A., Lu M., Harper D.,
RA Lindsay R., Hauser H., James K.D., Quiles M., Madan Babu M., Saito T.,
RA Buchrieser C., Wardroper A., Felder M., Thangavelu M., Johnson D.,
RA Knights A., Loulseged H., Mungall K.L., Oliver K., Price C., Quail M.A.,
RA Urushihara H., Hernandez J., Rabbinowitsch E., Steffen D., Sanders M.,
RA Ma J., Kohara Y., Sharp S., Simmonds M.N., Spiegler S., Tivey A.,
RA Sugano S., White B., Walker D., Woodward J.R., Winckler T., Tanaka Y.,
RA Shaulsky G., Schleicher M., Weinstock G.M., Rosenthal A., Cox E.C.,
RA Chisholm R.L., Gibbs R.A., Loomis W.F., Platzer M., Kay R.R.,
RA Williams J.G., Dear P.H., Noegel A.A., Barrell B.G., Kuspa A.;
RT "The genome of the social amoeba Dictyostelium discoideum.";
RL Nature 435:43-57(2005).
CC -!- FUNCTION: Probable adapter protein and signal transducer that links
CC members of the tumor necrosis factor receptor family to different
CC signaling pathways by association with the receptor cytoplasmic domain
CC and kinases. {ECO:0000250}.
CC -!- SUBCELLULAR LOCATION: Cytoplasm {ECO:0000250}.
CC -!- DOMAIN: The MATH/TRAF domain binds to receptor cytoplasmic domains.
CC -!- SIMILARITY: Belongs to the TNF receptor-associated factor family. A
CC subfamily. {ECO:0000305}.
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DR EMBL; AAFI02000008; EAL71326.1; -; Genomic_DNA.
DR RefSeq; XP_645161.1; XM_640069.1.
DR AlphaFoldDB; Q86KX6; -.
DR SMR; Q86KX6; -.
DR STRING; 44689.DDB0206580; -.
DR PaxDb; Q86KX6; -.
DR EnsemblProtists; EAL71326; EAL71326; DDB_G0272348.
DR GeneID; 8618332; -.
DR KEGG; ddi:DDB_G0272348; -.
DR dictyBase; DDB_G0272348; trafI.
DR eggNOG; KOG0297; Eukaryota.
DR HOGENOM; CLU_040980_0_0_1; -.
DR InParanoid; Q86KX6; -.
DR PhylomeDB; Q86KX6; -.
DR Reactome; R-DDI-5689880; Ub-specific processing proteases.
DR PRO; PR:Q86KX6; -.
DR Proteomes; UP000002195; Chromosome 2.
DR GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.
DR GO; GO:0008270; F:zinc ion binding; IEA:InterPro.
DR CDD; cd00121; MATH; 1.
DR Gene3D; 2.60.210.10; -; 1.
DR Gene3D; 3.30.40.10; -; 2.
DR InterPro; IPR002083; MATH/TRAF_dom.
DR InterPro; IPR043211; TNF_rcpt-assoc_TRAF.
DR InterPro; IPR008974; TRAF-like.
DR InterPro; IPR013083; Znf_RING/FYVE/PHD.
DR InterPro; IPR001293; Znf_TRAF.
DR PANTHER; PTHR10131; PTHR10131; 2.
DR Pfam; PF02176; zf-TRAF; 1.
DR PROSITE; PS50144; MATH; 1.
DR PROSITE; PS50145; ZF_TRAF; 1.
PE 3: Inferred from homology;
KW Coiled coil; Cytoplasm; Metal-binding; Reference proteome; Repeat; Zinc;
KW Zinc-finger.
FT CHAIN 1..595
FT /note="TNF receptor-associated factor family protein
FT DDB_G0272348"
FT /id="PRO_0000393761"
FT DOMAIN 456..584
FT /note="MATH"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00129"
FT ZN_FING 87..134
FT /note="RING-type; degenerate"
FT ZN_FING 189..253
FT /note="TRAF-type 1"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00207"
FT ZN_FING 254..311
FT /note="TRAF-type 2"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00207"
FT REGION 14..64
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 409..450
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COILED 348..410
FT /evidence="ECO:0000255"
SQ SEQUENCE 595 AA; 69161 MW; 9E4DE7240D2D66C0 CRC64;
MEFELEDITI EQSSFTNNNS NNNNNNNNNS NSNNNNNNNN NNINNNNNHN NNNKNNSNNK
NEINNQLDIP ISNLVVDKEN ISKKYFCTIC SDLLVNSFHA DKFKAVQCKN GHYTTCLNCW
EKHLEKKKNC IQCGVDVESI ESLSSNLLVT QKFTTFKIHC PNSFFDTIDF IKDEVNGCKE
IIQINELEEH LKECQYGFIS CKNCEEFSKL PFQEFTQCPD FRKNTKEQHD LICPYVKISC
EYCGDIINKI NKESHNANWC QEITIKCLDC HLPFKKKEIN QHQKSFCPET IIQCRYSKGG
CNAMIRRSKL SQHLTEGDNH HQFISNILNQ QDLKINELEL KNTEFCLLLN GQNKKITELE
ILFKELNDSI LIQKQQQKQQ QQQQQQQQQQ QQQQQQQQQS QQQQSQQQQQ SQQQQQSQQS
QQNNNSNSHF INNNNNNINN VQMSDSPNGG SLPQAVYKNK WVISNYSEQE QQGISKDYIK
SPLFKIGNST FFLKWFPFGK KKLNYCSIFL YKTQDDKSII VNYYIHLVNN QISDEVYEKR
GCQKYDSENG SAGYGSSQFI KRADLLNDAN GFLINDSITI EIEIFATEEI LPLQS
