ID   Y2349_STAAR             Reviewed;         146 AA.
AC   Q6GEG9;
DT   20-DEC-2005, integrated into UniProtKB/Swiss-Prot.
DT   19-JUL-2004, sequence version 1.
DT   25-MAY-2022, entry version 99.
DE   RecName: Full=Uncharacterized HTH-type transcriptional regulator SAR2349;
GN   OrderedLocusNames=SAR2349;
OS   Staphylococcus aureus (strain MRSA252).
OC   Bacteria; Firmicutes; Bacilli; Bacillales; Staphylococcaceae;
OC   Staphylococcus.
OX   NCBI_TaxID=282458;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=MRSA252;
RX   PubMed=15213324; DOI=10.1073/pnas.0402521101;
RA   Holden M.T.G., Feil E.J., Lindsay J.A., Peacock S.J., Day N.P.J.,
RA   Enright M.C., Foster T.J., Moore C.E., Hurst L., Atkin R., Barron A.,
RA   Bason N., Bentley S.D., Chillingworth C., Chillingworth T., Churcher C.,
RA   Clark L., Corton C., Cronin A., Doggett J., Dowd L., Feltwell T., Hance Z.,
RA   Harris B., Hauser H., Holroyd S., Jagels K., James K.D., Lennard N.,
RA   Line A., Mayes R., Moule S., Mungall K., Ormond D., Quail M.A.,
RA   Rabbinowitsch E., Rutherford K.M., Sanders M., Sharp S., Simmonds M.,
RA   Stevens K., Whitehead S., Barrell B.G., Spratt B.G., Parkhill J.;
RT   "Complete genomes of two clinical Staphylococcus aureus strains: evidence
RT   for the rapid evolution of virulence and drug resistance.";
RL   Proc. Natl. Acad. Sci. U.S.A. 101:9786-9791(2004).
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DR   EMBL; BX571856; CAG41330.1; -; Genomic_DNA.
DR   RefSeq; WP_000951069.1; NC_002952.2.
DR   PDB; 4EM0; X-ray; 2.90 A; B=1-146.
DR   PDB; 4EM1; X-ray; 3.00 A; A=1-146.
DR   PDB; 4EM2; X-ray; 2.08 A; A=1-146.
DR   PDBsum; 4EM0; -.
DR   PDBsum; 4EM1; -.
DR   PDBsum; 4EM2; -.
DR   AlphaFoldDB; Q6GEG9; -.
DR   SMR; Q6GEG9; -.
DR   KEGG; sar:SAR2349; -.
DR   HOGENOM; CLU_083287_18_2_9; -.
DR   OMA; FEQWLIM; -.
DR   OrthoDB; 1744037at2; -.
DR   Proteomes; UP000000596; Chromosome.
DR   GO; GO:0003677; F:DNA binding; IEA:UniProtKB-KW.
DR   GO; GO:0003700; F:DNA-binding transcription factor activity; IEA:InterPro.
DR   Gene3D; 1.10.10.10; -; 1.
DR   InterPro; IPR000835; HTH_MarR-typ.
DR   InterPro; IPR023187; Tscrpt_reg_MarR-type_CS.
DR   InterPro; IPR036388; WH-like_DNA-bd_sf.
DR   InterPro; IPR036390; WH_DNA-bd_sf.
DR   Pfam; PF01047; MarR; 1.
DR   SMART; SM00347; HTH_MARR; 1.
DR   SUPFAM; SSF46785; SSF46785; 1.
DR   PROSITE; PS01117; HTH_MARR_1; 1.
DR   PROSITE; PS50995; HTH_MARR_2; 1.
PE   1: Evidence at protein level;
KW   3D-structure; DNA-binding; Transcription; Transcription regulation.
FT   CHAIN           1..146
FT                   /note="Uncharacterized HTH-type transcriptional regulator
FT                   SAR2349"
FT                   /id="PRO_0000054415"
FT   DOMAIN          1..137
FT                   /note="HTH marR-type"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00345"
FT   HELIX           2..11
FT                   /evidence="ECO:0007829|PDB:4EM2"
FT   HELIX           14..27
FT                   /evidence="ECO:0007829|PDB:4EM2"
FT   HELIX           32..44
FT                   /evidence="ECO:0007829|PDB:4EM2"
FT   STRAND          46..48
FT                   /evidence="ECO:0007829|PDB:4EM0"
FT   HELIX           49..56
FT                   /evidence="ECO:0007829|PDB:4EM2"
FT   HELIX           60..72
FT                   /evidence="ECO:0007829|PDB:4EM2"
FT   STRAND          75..78
FT                   /evidence="ECO:0007829|PDB:4EM2"
FT   STRAND          81..83
FT                   /evidence="ECO:0007829|PDB:4EM1"
FT   HELIX           85..87
FT                   /evidence="ECO:0007829|PDB:4EM2"
FT   STRAND          90..92
FT                   /evidence="ECO:0007829|PDB:4EM2"
FT   HELIX           94..116
FT                   /evidence="ECO:0007829|PDB:4EM2"
FT   HELIX           122..142
FT                   /evidence="ECO:0007829|PDB:4EM2"
SQ   SEQUENCE   146 AA;  17182 MW;  20D7250E7AA73F1F CRC64;
     MLSQEFFNSF ITIYRPYLKL TEPILEKHNI YYGQWLILRD IAKHQPTTLI EISHRRAIEK
     PTARKTLKAL IENDLITVEN SLEDKRQKFL TLTPKGHELY EIVCLDVQKL QQAVVAKTNI
     SQDQMQETIN VMNQIHEILL KEAHND