Y2353_MYCBO
ID Y2353_MYCBO Reviewed; 697 AA.
AC P63400; A0A1R3Y1N7; P71886; X2BKR5;
DT 11-OCT-2004, integrated into UniProtKB/Swiss-Prot.
DT 11-OCT-2004, sequence version 1.
DT 03-AUG-2022, entry version 107.
DE RecName: Full=Uncharacterized ABC transporter ATP-binding protein Mb2353c;
GN OrderedLocusNames=BQ2027_MB2353C;
OS Mycobacterium bovis (strain ATCC BAA-935 / AF2122/97).
OC Bacteria; Actinobacteria; Corynebacteriales; Mycobacteriaceae;
OC Mycobacterium; Mycobacterium tuberculosis complex.
OX NCBI_TaxID=233413;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=ATCC BAA-935 / AF2122/97;
RX PubMed=12788972; DOI=10.1073/pnas.1130426100;
RA Garnier T., Eiglmeier K., Camus J.-C., Medina N., Mansoor H., Pryor M.,
RA Duthoy S., Grondin S., Lacroix C., Monsempe C., Simon S., Harris B.,
RA Atkin R., Doggett J., Mayes R., Keating L., Wheeler P.R., Parkhill J.,
RA Barrell B.G., Cole S.T., Gordon S.V., Hewinson R.G.;
RT "The complete genome sequence of Mycobacterium bovis.";
RL Proc. Natl. Acad. Sci. U.S.A. 100:7877-7882(2003).
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA], AND GENOME REANNOTATION.
RC STRAIN=ATCC BAA-935 / AF2122/97;
RX PubMed=28385856; DOI=10.1128/genomea.00157-17;
RA Malone K.M., Farrell D., Stuber T.P., Schubert O.T., Aebersold R.,
RA Robbe-Austerman S., Gordon S.V.;
RT "Updated reference genome sequence and annotation of Mycobacterium bovis
RT AF2122/97.";
RL Genome Announc. 5:E00157-E00157(2017).
CC -!- SUBCELLULAR LOCATION: Cell membrane {ECO:0000305}; Multi-pass membrane
CC protein {ECO:0000305}.
CC -!- SIMILARITY: Belongs to the ABC transporter superfamily. {ECO:0000305}.
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DR EMBL; LT708304; SIU00965.1; -; Genomic_DNA.
DR RefSeq; NP_856002.1; NC_002945.3.
DR RefSeq; WP_003411969.1; NC_002945.4.
DR AlphaFoldDB; P63400; -.
DR SMR; P63400; -.
DR EnsemblBacteria; SIU00965; SIU00965; BQ2027_MB2353C.
DR PATRIC; fig|233413.5.peg.2580; -.
DR OMA; SFISWSA; -.
DR Proteomes; UP000001419; Chromosome.
DR GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR GO; GO:0005886; C:plasma membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0005524; F:ATP binding; IEA:UniProtKB-KW.
DR GO; GO:0055085; P:transmembrane transport; IEA:InterPro.
DR CDD; cd03225; ABC_cobalt_CbiO_domain1; 2.
DR Gene3D; 3.40.50.300; -; 2.
DR InterPro; IPR003593; AAA+_ATPase.
DR InterPro; IPR003439; ABC_transporter-like_ATP-bd.
DR InterPro; IPR017871; ABC_transporter-like_CS.
DR InterPro; IPR015856; ABC_transpr_CbiO/EcfA_su.
DR InterPro; IPR027417; P-loop_NTPase.
DR Pfam; PF00005; ABC_tran; 2.
DR SMART; SM00382; AAA; 2.
DR SUPFAM; SSF52540; SSF52540; 2.
DR PROSITE; PS00211; ABC_TRANSPORTER_1; 2.
DR PROSITE; PS50893; ABC_TRANSPORTER_2; 2.
PE 3: Inferred from homology;
KW ATP-binding; Cell membrane; Membrane; Nucleotide-binding; Repeat;
KW Transmembrane; Transmembrane helix; Transport.
FT CHAIN 1..697
FT /note="Uncharacterized ABC transporter ATP-binding protein
FT Mb2353c"
FT /id="PRO_0000093267"
FT TRANSMEM 45..65
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 86..106
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 128..148
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 198..218
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 280..300
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 522..542
FT /note="Helical"
FT /evidence="ECO:0000255"
FT DOMAIN 251..473
FT /note="ABC transporter 1"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00434"
FT DOMAIN 477..696
FT /note="ABC transporter 2"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00434"
FT BINDING 285..292
FT /ligand="ATP"
FT /ligand_id="ChEBI:CHEBI:30616"
FT /ligand_label="1"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00434"
FT BINDING 514..521
FT /ligand="ATP"
FT /ligand_id="ChEBI:CHEBI:30616"
FT /ligand_label="2"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00434"
SQ SEQUENCE 697 AA; 72835 MW; CB7759BE1E2F047E CRC64;
MCCAVCGPEP GRIGEVTPLG PCPAQHRGGP LRPSELAQAS VMAALCAVTA IISVVVPFAA
GLALLGTVPT GLLAYRYRLR VLAAATVAAG MIAFLIAGLG GFMGVVHSAY IGGLTGIVKR
RGRGTPTVVV SSLIGGFVFG AAMVGMLAAM VRLRHLIFKV MTANVDGIAA TLARMHMQGA
AADVKRYFAE GLQYWPWVLL GYFNIGIMIV SLIGWWALSR LLERMRGIPD VHKLDPPPGD
DVDALIGPVP VRLDKVRFRY PRAGQDALRE VSLDVRAGEH LAIIGANGSG KTTLMLILAG
RAPTSGTVDR PGTVGLGKLG GTAVVLQHPE SQVLGTRVAD DVVWGLPLGT TADVGRLLSE
VGLEALAERD TGSLSGGELQ RLALAAALAR EPAMLIADEV TTMVDQQGRD ALLAVLSGLT
QRHRTALVHI THYDNEADSA DRTLSLSDSP DNTDMVHTAA MPAPVIGVDQ PQHAPALELV
GVGHEYASGT PWAKTALRDI NFVVEQGDGV LIHGGNGSGK STLAWIMAGL TIPTTGACLL
DGRPTHEQVG AVALSFQAAR LQLMRSRVDL EVASAAGFSA SEQDRVAAAL TVVGLDPALG
ARRIDQLSGG QMRRVVLAGL LARAPRALIL DEPLAGLDAA SQRGLLRLLE DLRRARGLTV
VVVSHDFAGM EELCPRTLHL RDGVLESAAA SEAGGMS