ID   Y2366_MYCTU             Reviewed;         435 AA.
AC   P9WFP1; L0T9E9; O05832; P67130;
DT   16-APR-2014, integrated into UniProtKB/Swiss-Prot.
DT   16-APR-2014, sequence version 1.
DT   25-MAY-2022, entry version 41.
DE   RecName: Full=UPF0053 protein Rv2366c;
GN   OrderedLocusNames=Rv2366c; ORFNames=MTCY27.14;
OS   Mycobacterium tuberculosis (strain ATCC 25618 / H37Rv).
OC   Bacteria; Actinobacteria; Corynebacteriales; Mycobacteriaceae;
OC   Mycobacterium; Mycobacterium tuberculosis complex.
OX   NCBI_TaxID=83332;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=ATCC 25618 / H37Rv;
RX   PubMed=9634230; DOI=10.1038/31159;
RA   Cole S.T., Brosch R., Parkhill J., Garnier T., Churcher C.M., Harris D.E.,
RA   Gordon S.V., Eiglmeier K., Gas S., Barry C.E. III, Tekaia F., Badcock K.,
RA   Basham D., Brown D., Chillingworth T., Connor R., Davies R.M., Devlin K.,
RA   Feltwell T., Gentles S., Hamlin N., Holroyd S., Hornsby T., Jagels K.,
RA   Krogh A., McLean J., Moule S., Murphy L.D., Oliver S., Osborne J.,
RA   Quail M.A., Rajandream M.A., Rogers J., Rutter S., Seeger K., Skelton S.,
RA   Squares S., Squares R., Sulston J.E., Taylor K., Whitehead S.,
RA   Barrell B.G.;
RT   "Deciphering the biology of Mycobacterium tuberculosis from the complete
RT   genome sequence.";
RL   Nature 393:537-544(1998).
RN   [2]
RP   IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
RC   STRAIN=ATCC 25618 / H37Rv;
RX   PubMed=21969609; DOI=10.1074/mcp.m111.011627;
RA   Kelkar D.S., Kumar D., Kumar P., Balakrishnan L., Muthusamy B., Yadav A.K.,
RA   Shrivastava P., Marimuthu A., Anand S., Sundaram H., Kingsbury R.,
RA   Harsha H.C., Nair B., Prasad T.S., Chauhan D.S., Katoch K., Katoch V.M.,
RA   Kumar P., Chaerkady R., Ramachandran S., Dash D., Pandey A.;
RT   "Proteogenomic analysis of Mycobacterium tuberculosis by high resolution
RT   mass spectrometry.";
RL   Mol. Cell. Proteomics 10:M111.011627-M111.011627(2011).
CC   -!- SUBCELLULAR LOCATION: Cell membrane {ECO:0000305}; Multi-pass membrane
CC       protein {ECO:0000305}.
CC   -!- SIMILARITY: Belongs to the UPF0053 family. {ECO:0000305}.
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DR   EMBL; AL123456; CCP45154.1; -; Genomic_DNA.
DR   PIR; E70586; E70586.
DR   RefSeq; NP_216882.1; NC_000962.3.
DR   RefSeq; WP_003412229.1; NZ_NVQJ01000029.1.
DR   AlphaFoldDB; P9WFP1; -.
DR   SMR; P9WFP1; -.
DR   STRING; 83332.Rv2366c; -.
DR   PaxDb; P9WFP1; -.
DR   DNASU; 885987; -.
DR   GeneID; 885987; -.
DR   KEGG; mtu:Rv2366c; -.
DR   TubercuList; Rv2366c; -.
DR   eggNOG; COG1253; Bacteria.
DR   OMA; TIGRQHP; -.
DR   PhylomeDB; P9WFP1; -.
DR   Proteomes; UP000001584; Chromosome.
DR   GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR   GO; GO:0005886; C:plasma membrane; HDA:MTBBASE.
DR   GO; GO:0050660; F:flavin adenine dinucleotide binding; IEA:InterPro.
DR   CDD; cd04590; CBS_pair_CorC_HlyC_assoc; 1.
DR   Gene3D; 3.10.580.10; -; 1.
DR   Gene3D; 3.30.465.10; -; 1.
DR   InterPro; IPR000644; CBS_dom.
DR   InterPro; IPR046342; CBS_dom_sf.
DR   InterPro; IPR002550; CNNM.
DR   InterPro; IPR036318; FAD-bd_PCMH-like_sf.
DR   InterPro; IPR016169; FAD-bd_PCMH_sub2.
DR   InterPro; IPR044751; Ion_transp-like_CBS.
DR   InterPro; IPR005170; Transptr-assoc_dom.
DR   Pfam; PF00571; CBS; 2.
DR   Pfam; PF03471; CorC_HlyC; 1.
DR   Pfam; PF01595; DUF21; 1.
DR   SMART; SM00116; CBS; 2.
DR   SMART; SM01091; CorC_HlyC; 1.
DR   SUPFAM; SSF54631; SSF54631; 1.
DR   SUPFAM; SSF56176; SSF56176; 1.
DR   PROSITE; PS51371; CBS; 2.
DR   PROSITE; PS51846; CNNM; 1.
PE   1: Evidence at protein level;
KW   CBS domain; Cell membrane; Membrane; Reference proteome; Repeat;
KW   Transmembrane; Transmembrane helix.
FT   CHAIN           1..435
FT                   /note="UPF0053 protein Rv2366c"
FT                   /id="PRO_0000088381"
FT   TRANSMEM        7..27
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        89..109
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   DOMAIN          1..185
FT                   /note="CNNM transmembrane"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU01193"
FT   DOMAIN          204..267
FT                   /note="CBS 1"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00703"
FT   DOMAIN          272..329
FT                   /note="CBS 2"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00703"
SQ   SEQUENCE   435 AA;  47213 MW;  C12E988EC190DD4A CRC64;
     MTGYYQLLGS IVLIGLGGLF AAIDAAISTV SPARVDELVR DQRPGAGSLR KVMADRPRYV
     NLVVLLRTSC EITATALLVV FIRYHFSMVW GLYLAAGIMV LASFVVVGVG PRTLGRQNAY
     SISLATALPL RLISWLLMPI SRLLVLLGNA LTPGRGFRNG PFASEIELRE VVDLAQQRGV
     VAADERRMIE SVFELGDTPA REVMVPRTEM IWIESDKTAG QAMTLAVRSG HSRIPVIGEN
     VDDIVGVVYL KDLVEQTFCS TNGGRETTVA RVMRPAVFVP DSKPLDALLR EMQRDRNHMA
     LLVDEYGAIA GLVSIEDVLE EIVGEIADEY DQAETAPVED LGDKRFRVSA RLPIEDVGEL
     YGVEFDDDLD VDTVGGLLAL ELGRVPLPGA EVISHGLRLH AEGGTDHRGR VRIGTVLLSP
     AEPDGADDEE ADHPG