Y2370_STAAS
ID Y2370_STAAS Reviewed; 231 AA.
AC Q6G6J1;
DT 11-SEP-2007, integrated into UniProtKB/Swiss-Prot.
DT 19-JUL-2004, sequence version 1.
DT 03-AUG-2022, entry version 93.
DE RecName: Full=Uncharacterized oxidoreductase SAS2370;
DE EC=1.-.-.-;
GN OrderedLocusNames=SAS2370;
OS Staphylococcus aureus (strain MSSA476).
OC Bacteria; Firmicutes; Bacilli; Bacillales; Staphylococcaceae;
OC Staphylococcus.
OX NCBI_TaxID=282459;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=MSSA476;
RX PubMed=15213324; DOI=10.1073/pnas.0402521101;
RA Holden M.T.G., Feil E.J., Lindsay J.A., Peacock S.J., Day N.P.J.,
RA Enright M.C., Foster T.J., Moore C.E., Hurst L., Atkin R., Barron A.,
RA Bason N., Bentley S.D., Chillingworth C., Chillingworth T., Churcher C.,
RA Clark L., Corton C., Cronin A., Doggett J., Dowd L., Feltwell T., Hance Z.,
RA Harris B., Hauser H., Holroyd S., Jagels K., James K.D., Lennard N.,
RA Line A., Mayes R., Moule S., Mungall K., Ormond D., Quail M.A.,
RA Rabbinowitsch E., Rutherford K.M., Sanders M., Sharp S., Simmonds M.,
RA Stevens K., Whitehead S., Barrell B.G., Spratt B.G., Parkhill J.;
RT "Complete genomes of two clinical Staphylococcus aureus strains: evidence
RT for the rapid evolution of virulence and drug resistance.";
RL Proc. Natl. Acad. Sci. U.S.A. 101:9786-9791(2004).
CC -!- SIMILARITY: Belongs to the short-chain dehydrogenases/reductases (SDR)
CC family. {ECO:0000305}.
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DR EMBL; BX571857; CAG44184.1; -; Genomic_DNA.
DR RefSeq; WP_000217458.1; NC_002953.3.
DR AlphaFoldDB; Q6G6J1; -.
DR SMR; Q6G6J1; -.
DR KEGG; sas:SAS2370; -.
DR HOGENOM; CLU_010194_2_10_9; -.
DR OMA; ITGGRNW; -.
DR GO; GO:0016491; F:oxidoreductase activity; IEA:UniProtKB-KW.
DR InterPro; IPR036291; NAD(P)-bd_dom_sf.
DR InterPro; IPR002347; SDR_fam.
DR Pfam; PF00106; adh_short; 1.
DR PRINTS; PR00081; GDHRDH.
DR PRINTS; PR00080; SDRFAMILY.
DR SUPFAM; SSF51735; SSF51735; 1.
PE 3: Inferred from homology;
KW Oxidoreductase.
FT CHAIN 1..231
FT /note="Uncharacterized oxidoreductase SAS2370"
FT /id="PRO_0000300472"
FT ACT_SITE 153
FT /note="Proton acceptor"
FT /evidence="ECO:0000250"
FT BINDING 10..34
FT /ligand="NADP(+)"
FT /ligand_id="ChEBI:CHEBI:58349"
FT /evidence="ECO:0000250"
FT BINDING 140
FT /ligand="substrate"
FT /evidence="ECO:0000250"
SQ SEQUENCE 231 AA; 24577 MW; BDA4ACD8D903F40F CRC64;
MTVLTDKIAV VTGAGSGIGE AIATLLHEEG AKVVLAGRNK EKLQNVANQL SQDSVKVVPT
DVTNKEEVDE LIKIAQQTFG GLDIVINSAG QMLSSKITDY QVDEWDSMID VNIKGTLYTV
QAALPTMLEQ SSGHLINIAS ISGFEVTKSS TIYSATKAAV HTITQGLEKE LAKTGVKVTS
ISPGMVDTAI TAAYNPSDRK KLDPQDIAEA VLYALTQPSH VNVNEITVRP V