ID   Y2383_VIBCH             Reviewed;         286 AA.
AC   Q9KPI4; P24544;
DT   01-DEC-2000, integrated into UniProtKB/Swiss-Prot.
DT   01-OCT-2000, sequence version 1.
DT   03-AUG-2022, entry version 112.
DE   RecName: Full=Uncharacterized HTH-type transcriptional regulator VC_2383;
GN   OrderedLocusNames=VC_2383;
OS   Vibrio cholerae serotype O1 (strain ATCC 39315 / El Tor Inaba N16961).
OC   Bacteria; Proteobacteria; Gammaproteobacteria; Vibrionales; Vibrionaceae;
OC   Vibrio.
OX   NCBI_TaxID=243277;
RN   [1]
RP   PRELIMINARY NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RC   STRAIN=ATCC 25870 / Classical Inaba 569B / Serotype O1;
RX   PubMed=1741267; DOI=10.1093/nar/20.2.372;
RA   Ghosh S.K., Biswas S.K., Paul K., Das J.;
RT   "Nucleotide and deduced amino acid sequence of the recA gene of Vibrio
RT   cholerae.";
RL   Nucleic Acids Res. 20:372-372(1992).
RN   [2]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=ATCC 39315 / El Tor Inaba N16961;
RX   PubMed=10952301; DOI=10.1038/35020000;
RA   Heidelberg J.F., Eisen J.A., Nelson W.C., Clayton R.A., Gwinn M.L.,
RA   Dodson R.J., Haft D.H., Hickey E.K., Peterson J.D., Umayam L.A., Gill S.R.,
RA   Nelson K.E., Read T.D., Tettelin H., Richardson D.L., Ermolaeva M.D.,
RA   Vamathevan J.J., Bass S., Qin H., Dragoi I., Sellers P., McDonald L.A.,
RA   Utterback T.R., Fleischmann R.D., Nierman W.C., White O., Salzberg S.L.,
RA   Smith H.O., Colwell R.R., Mekalanos J.J., Venter J.C., Fraser C.M.;
RT   "DNA sequence of both chromosomes of the cholera pathogen Vibrio
RT   cholerae.";
RL   Nature 406:477-483(2000).
CC   -!- SIMILARITY: Belongs to the LysR transcriptional regulatory family.
CC       {ECO:0000305}.
CC   -!- CAUTION: Was originally thought to be recA; but the sequence was
CC       incorrectly assigned. {ECO:0000305|PubMed:1741267}.
CC   -!- SEQUENCE CAUTION:
CC       Sequence=CAA43657.1; Type=Frameshift; Evidence={ECO:0000305};
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DR   EMBL; X61384; CAA43657.1; ALT_FRAME; Genomic_DNA.
DR   EMBL; AE003852; AAF95526.1; -; Genomic_DNA.
DR   PIR; F82082; F82082.
DR   RefSeq; NP_232013.1; NC_002505.1.
DR   RefSeq; WP_000923496.1; NZ_LT906614.1.
DR   AlphaFoldDB; Q9KPI4; -.
DR   SMR; Q9KPI4; -.
DR   STRING; 243277.VC_2383; -.
DR   PRIDE; Q9KPI4; -.
DR   DNASU; 2613052; -.
DR   EnsemblBacteria; AAF95526; AAF95526; VC_2383.
DR   GeneID; 57740991; -.
DR   GeneID; 66939781; -.
DR   KEGG; vch:VC_2383; -.
DR   PATRIC; fig|243277.26.peg.2269; -.
DR   eggNOG; COG0583; Bacteria.
DR   HOGENOM; CLU_077403_0_0_6; -.
DR   OMA; LASEGTM; -.
DR   BioCyc; VCHO:VC2383-MON; -.
DR   Proteomes; UP000000584; Chromosome 1.
DR   GO; GO:0003700; F:DNA-binding transcription factor activity; IEA:InterPro.
DR   GO; GO:0000976; F:transcription cis-regulatory region binding; IBA:GO_Central.
DR   GO; GO:0006355; P:regulation of transcription, DNA-templated; IBA:GO_Central.
DR   Gene3D; 1.10.10.10; -; 1.
DR   InterPro; IPR005119; LysR_subst-bd.
DR   InterPro; IPR000847; Tscrpt_reg_HTH_LysR.
DR   InterPro; IPR036388; WH-like_DNA-bd_sf.
DR   InterPro; IPR036390; WH_DNA-bd_sf.
DR   Pfam; PF00126; HTH_1; 1.
DR   Pfam; PF03466; LysR_substrate; 1.
DR   SUPFAM; SSF46785; SSF46785; 1.
DR   PROSITE; PS50931; HTH_LYSR; 1.
PE   3: Inferred from homology;
KW   DNA-binding; Reference proteome; Transcription; Transcription regulation.
FT   CHAIN           1..286
FT                   /note="Uncharacterized HTH-type transcriptional regulator
FT                   VC_2383"
FT                   /id="PRO_0000105828"
FT   DOMAIN          1..58
FT                   /note="HTH lysR-type"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00253"
FT   DNA_BIND        18..37
FT                   /note="H-T-H motif"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00253"
SQ   SEQUENCE   286 AA;  31211 MW;  29D1CB010182DF3B CRC64;
     MLLEGIETLL VLSKEKTMSR TGSQLYISQS AVSKRIANLE KKLGKKLIVP AGRHIKLTAD
     AEQLIASIGP TFNELHGLIF EQQTLEDNTL LRMDCSETLV AGYLGQTMGQ HRKQDPHWVI
     TTNHTPRIVE NVQSGKATLG FCAGYLPANH GLLTFHLGDE PFTVISQAPL HALPSELITN
     DLANPANTYQ AAMLHKQGIR PAMEMDSYTA AAQLALGGML PALVPRSIVS TLKIEPQHCF
     DFAELADLTR PIHICLRASR YRSSRVQALI TALHDAVPKA VLAPSA