ID   Y2387_MYCBO             Reviewed;         435 AA.
AC   P67131; A0A1R3Y101; O05832; X2BKF9;
DT   11-OCT-2004, integrated into UniProtKB/Swiss-Prot.
DT   11-OCT-2004, sequence version 1.
DT   25-MAY-2022, entry version 103.
DE   RecName: Full=UPF0053 protein Mb2387c;
GN   OrderedLocusNames=BQ2027_MB2387C;
OS   Mycobacterium bovis (strain ATCC BAA-935 / AF2122/97).
OC   Bacteria; Actinobacteria; Corynebacteriales; Mycobacteriaceae;
OC   Mycobacterium; Mycobacterium tuberculosis complex.
OX   NCBI_TaxID=233413;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=ATCC BAA-935 / AF2122/97;
RX   PubMed=12788972; DOI=10.1073/pnas.1130426100;
RA   Garnier T., Eiglmeier K., Camus J.-C., Medina N., Mansoor H., Pryor M.,
RA   Duthoy S., Grondin S., Lacroix C., Monsempe C., Simon S., Harris B.,
RA   Atkin R., Doggett J., Mayes R., Keating L., Wheeler P.R., Parkhill J.,
RA   Barrell B.G., Cole S.T., Gordon S.V., Hewinson R.G.;
RT   "The complete genome sequence of Mycobacterium bovis.";
RL   Proc. Natl. Acad. Sci. U.S.A. 100:7877-7882(2003).
RN   [2]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA], AND GENOME REANNOTATION.
RC   STRAIN=ATCC BAA-935 / AF2122/97;
RX   PubMed=28385856; DOI=10.1128/genomea.00157-17;
RA   Malone K.M., Farrell D., Stuber T.P., Schubert O.T., Aebersold R.,
RA   Robbe-Austerman S., Gordon S.V.;
RT   "Updated reference genome sequence and annotation of Mycobacterium bovis
RT   AF2122/97.";
RL   Genome Announc. 5:E00157-E00157(2017).
CC   -!- SUBCELLULAR LOCATION: Cell membrane {ECO:0000305}; Multi-pass membrane
CC       protein {ECO:0000305}.
CC   -!- SIMILARITY: Belongs to the UPF0053 family. {ECO:0000305}.
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DR   EMBL; LT708304; SIU00999.1; -; Genomic_DNA.
DR   RefSeq; NP_856036.1; NC_002945.3.
DR   RefSeq; WP_003412229.1; NC_002945.4.
DR   AlphaFoldDB; P67131; -.
DR   SMR; P67131; -.
DR   EnsemblBacteria; SIU00999; SIU00999; BQ2027_MB2387C.
DR   PATRIC; fig|233413.5.peg.2622; -.
DR   OMA; TIGRQHP; -.
DR   Proteomes; UP000001419; Chromosome.
DR   GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR   GO; GO:0005886; C:plasma membrane; IEA:UniProtKB-SubCell.
DR   GO; GO:0050660; F:flavin adenine dinucleotide binding; IEA:InterPro.
DR   CDD; cd04590; CBS_pair_CorC_HlyC_assoc; 1.
DR   Gene3D; 3.10.580.10; -; 1.
DR   Gene3D; 3.30.465.10; -; 1.
DR   InterPro; IPR000644; CBS_dom.
DR   InterPro; IPR046342; CBS_dom_sf.
DR   InterPro; IPR002550; CNNM.
DR   InterPro; IPR036318; FAD-bd_PCMH-like_sf.
DR   InterPro; IPR016169; FAD-bd_PCMH_sub2.
DR   InterPro; IPR044751; Ion_transp-like_CBS.
DR   InterPro; IPR005170; Transptr-assoc_dom.
DR   Pfam; PF00571; CBS; 2.
DR   Pfam; PF03471; CorC_HlyC; 1.
DR   Pfam; PF01595; DUF21; 1.
DR   SMART; SM00116; CBS; 2.
DR   SMART; SM01091; CorC_HlyC; 1.
DR   SUPFAM; SSF54631; SSF54631; 1.
DR   SUPFAM; SSF56176; SSF56176; 1.
DR   PROSITE; PS51371; CBS; 2.
DR   PROSITE; PS51846; CNNM; 1.
PE   3: Inferred from homology;
KW   CBS domain; Cell membrane; Membrane; Repeat; Transmembrane;
KW   Transmembrane helix.
FT   CHAIN           1..435
FT                   /note="UPF0053 protein Mb2387c"
FT                   /id="PRO_0000088382"
FT   TRANSMEM        7..27
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        89..109
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   DOMAIN          1..185
FT                   /note="CNNM transmembrane"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU01193"
FT   DOMAIN          204..267
FT                   /note="CBS 1"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00703"
FT   DOMAIN          272..329
FT                   /note="CBS 2"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00703"
SQ   SEQUENCE   435 AA;  47213 MW;  C12E988EC190DD4A CRC64;
     MTGYYQLLGS IVLIGLGGLF AAIDAAISTV SPARVDELVR DQRPGAGSLR KVMADRPRYV
     NLVVLLRTSC EITATALLVV FIRYHFSMVW GLYLAAGIMV LASFVVVGVG PRTLGRQNAY
     SISLATALPL RLISWLLMPI SRLLVLLGNA LTPGRGFRNG PFASEIELRE VVDLAQQRGV
     VAADERRMIE SVFELGDTPA REVMVPRTEM IWIESDKTAG QAMTLAVRSG HSRIPVIGEN
     VDDIVGVVYL KDLVEQTFCS TNGGRETTVA RVMRPAVFVP DSKPLDALLR EMQRDRNHMA
     LLVDEYGAIA GLVSIEDVLE EIVGEIADEY DQAETAPVED LGDKRFRVSA RLPIEDVGEL
     YGVEFDDDLD VDTVGGLLAL ELGRVPLPGA EVISHGLRLH AEGGTDHRGR VRIGTVLLSP
     AEPDGADDEE ADHPG