ID   Y2405_STAEQ             Reviewed;         512 AA.
AC   Q5HKE1;
DT   21-AUG-2007, integrated into UniProtKB/Swiss-Prot.
DT   15-FEB-2005, sequence version 1.
DT   25-MAY-2022, entry version 105.
DE   RecName: Full=Uncharacterized sensor-like histidine kinase SERP2405;
DE            EC=2.7.13.3;
GN   OrderedLocusNames=SERP2405;
OS   Staphylococcus epidermidis (strain ATCC 35984 / RP62A).
OC   Bacteria; Firmicutes; Bacilli; Bacillales; Staphylococcaceae;
OC   Staphylococcus.
OX   NCBI_TaxID=176279;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=ATCC 35984 / RP62A;
RX   PubMed=15774886; DOI=10.1128/jb.187.7.2426-2438.2005;
RA   Gill S.R., Fouts D.E., Archer G.L., Mongodin E.F., DeBoy R.T., Ravel J.,
RA   Paulsen I.T., Kolonay J.F., Brinkac L.M., Beanan M.J., Dodson R.J.,
RA   Daugherty S.C., Madupu R., Angiuoli S.V., Durkin A.S., Haft D.H.,
RA   Vamathevan J.J., Khouri H., Utterback T.R., Lee C., Dimitrov G., Jiang L.,
RA   Qin H., Weidman J., Tran K., Kang K.H., Hance I.R., Nelson K.E.,
RA   Fraser C.M.;
RT   "Insights on evolution of virulence and resistance from the complete genome
RT   analysis of an early methicillin-resistant Staphylococcus aureus strain and
RT   a biofilm-producing methicillin-resistant Staphylococcus epidermidis
RT   strain.";
RL   J. Bacteriol. 187:2426-2438(2005).
CC   -!- FUNCTION: Probable member of the two-component regulatory system
CC       SERP2405/SERP2406. May activate SERP2406 by phosphorylation (By
CC       similarity). {ECO:0000250}.
CC   -!- CATALYTIC ACTIVITY:
CC       Reaction=ATP + protein L-histidine = ADP + protein N-phospho-L-
CC         histidine.; EC=2.7.13.3;
CC   -!- SUBCELLULAR LOCATION: Cell membrane {ECO:0000305}; Multi-pass membrane
CC       protein {ECO:0000305}.
CC   -!- PTM: Autophosphorylated. {ECO:0000250}.
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DR   EMBL; CP000029; AAW53252.1; -; Genomic_DNA.
DR   RefSeq; WP_002505316.1; NC_002976.3.
DR   AlphaFoldDB; Q5HKE1; -.
DR   SMR; Q5HKE1; -.
DR   STRING; 176279.SERP2405; -.
DR   PRIDE; Q5HKE1; -.
DR   EnsemblBacteria; AAW53252; AAW53252; SERP2405.
DR   KEGG; ser:SERP2405; -.
DR   eggNOG; COG2972; Bacteria.
DR   HOGENOM; CLU_525720_0_0_9; -.
DR   OMA; YIWVEHR; -.
DR   OrthoDB; 1031920at2; -.
DR   Proteomes; UP000000531; Chromosome.
DR   GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR   GO; GO:0005886; C:plasma membrane; IEA:UniProtKB-SubCell.
DR   GO; GO:0005524; F:ATP binding; IEA:UniProtKB-KW.
DR   GO; GO:0000155; F:phosphorelay sensor kinase activity; IEA:InterPro.
DR   Gene3D; 3.30.565.10; -; 1.
DR   InterPro; IPR003594; HATPase_C.
DR   InterPro; IPR036890; HATPase_C_sf.
DR   InterPro; IPR010559; Sig_transdc_His_kin_internal.
DR   Pfam; PF02518; HATPase_c; 1.
DR   Pfam; PF06580; His_kinase; 1.
DR   SUPFAM; SSF55874; SSF55874; 1.
PE   3: Inferred from homology;
KW   ATP-binding; Cell membrane; Kinase; Membrane; Nucleotide-binding;
KW   Phosphoprotein; Reference proteome; Transferase; Transmembrane;
KW   Transmembrane helix; Two-component regulatory system.
FT   CHAIN           1..512
FT                   /note="Uncharacterized sensor-like histidine kinase
FT                   SERP2405"
FT                   /id="PRO_0000299129"
FT   TRANSMEM        20..40
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        222..242
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   DOMAIN          297..512
FT                   /note="Histidine kinase"
FT   MOD_RES         325
FT                   /note="Phosphohistidine; by autocatalysis"
FT                   /evidence="ECO:0000250"
SQ   SEQUENCE   512 AA;  60392 MW;  50432E13C10FE2EC CRC64;
     MKTYKPYRHQ LRRSLFASTI FPVFMVMIIG LISFYAIYIW VEHRTIHQHT YQTQTELQRI
     DKHFHTFVTQ QQKQWRHVDL SHPTDITKMK RQLLKQVHQQ PAILYYDLKG SSQSFTNNYE
     QLDTTKMYLI SKYRIDFKDD TYILKIYMSS TPLLKNIKKN SGQSALIVDS YDTVLYTNDD
     RFSIGQKYQP PQFGFMNESL KLNSHHAHLI IYKDIHETIE DGIALLVVMG VVLILLVIFG
     YISADRMAKR QSEDIEAIVR KIDDAKNRHL GSYEPLKKHS ELEEINNYIY DLFESNEQLI
     QSIEQTERRL RDIQLKEIER QFQPHFLFNT MQTIQYLIPL SPKVAQTVIQ QLSQMLRYSL
     RTASHTVKLA EELSYIQQYV AIQNIRFDDM IQLYIDAPED VQHQTIGKMM LQPLVENAIK
     HGRGSEPLKI TIRIRLTKRK LHILVHDNGI GMSPSHLERV RQSLHHDVFD TTHLGLNHLH
     NRAIIQYGTY ARLHIFSRSH QGTLMCYQIP LV