ID   Y2406_STAEQ             Reviewed;         251 AA.
AC   Q5HKE0;
DT   21-AUG-2007, integrated into UniProtKB/Swiss-Prot.
DT   15-FEB-2005, sequence version 1.
DT   25-MAY-2022, entry version 112.
DE   RecName: Full=Uncharacterized response regulatory protein SERP2406;
GN   OrderedLocusNames=SERP2406;
OS   Staphylococcus epidermidis (strain ATCC 35984 / RP62A).
OC   Bacteria; Firmicutes; Bacilli; Bacillales; Staphylococcaceae;
OC   Staphylococcus.
OX   NCBI_TaxID=176279;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=ATCC 35984 / RP62A;
RX   PubMed=15774886; DOI=10.1128/jb.187.7.2426-2438.2005;
RA   Gill S.R., Fouts D.E., Archer G.L., Mongodin E.F., DeBoy R.T., Ravel J.,
RA   Paulsen I.T., Kolonay J.F., Brinkac L.M., Beanan M.J., Dodson R.J.,
RA   Daugherty S.C., Madupu R., Angiuoli S.V., Durkin A.S., Haft D.H.,
RA   Vamathevan J.J., Khouri H., Utterback T.R., Lee C., Dimitrov G., Jiang L.,
RA   Qin H., Weidman J., Tran K., Kang K.H., Hance I.R., Nelson K.E.,
RA   Fraser C.M.;
RT   "Insights on evolution of virulence and resistance from the complete genome
RT   analysis of an early methicillin-resistant Staphylococcus aureus strain and
RT   a biofilm-producing methicillin-resistant Staphylococcus epidermidis
RT   strain.";
RL   J. Bacteriol. 187:2426-2438(2005).
CC   -!- FUNCTION: Probable member of the two-component regulatory system
CC       SERP2405/SERP2406. {ECO:0000250}.
CC   -!- SUBCELLULAR LOCATION: Cytoplasm {ECO:0000305}.
CC   -!- PTM: Phosphorylated by SERP2405. {ECO:0000305}.
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DR   EMBL; CP000029; AAW53253.1; -; Genomic_DNA.
DR   RefSeq; WP_002502644.1; NC_002976.3.
DR   AlphaFoldDB; Q5HKE0; -.
DR   SMR; Q5HKE0; -.
DR   STRING; 176279.SERP2406; -.
DR   PRIDE; Q5HKE0; -.
DR   EnsemblBacteria; AAW53253; AAW53253; SERP2406.
DR   KEGG; ser:SERP2406; -.
DR   eggNOG; COG2207; Bacteria.
DR   eggNOG; COG4753; Bacteria.
DR   HOGENOM; CLU_000445_5_1_9; -.
DR   OMA; IMTAFEM; -.
DR   OrthoDB; 1755994at2; -.
DR   Proteomes; UP000000531; Chromosome.
DR   GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.
DR   GO; GO:0003700; F:DNA-binding transcription factor activity; IEA:InterPro.
DR   GO; GO:0043565; F:sequence-specific DNA binding; IEA:InterPro.
DR   GO; GO:0000160; P:phosphorelay signal transduction system; IEA:UniProtKB-KW.
DR   InterPro; IPR011006; CheY-like_superfamily.
DR   InterPro; IPR009057; Homeobox-like_sf.
DR   InterPro; IPR018060; HTH_AraC.
DR   InterPro; IPR001789; Sig_transdc_resp-reg_receiver.
DR   Pfam; PF12833; HTH_18; 1.
DR   Pfam; PF00072; Response_reg; 1.
DR   SMART; SM00342; HTH_ARAC; 1.
DR   SMART; SM00448; REC; 1.
DR   SUPFAM; SSF46689; SSF46689; 2.
DR   SUPFAM; SSF52172; SSF52172; 1.
DR   PROSITE; PS01124; HTH_ARAC_FAMILY_2; 1.
DR   PROSITE; PS50110; RESPONSE_REGULATORY; 1.
PE   3: Inferred from homology;
KW   Cytoplasm; DNA-binding; Phosphoprotein; Reference proteome; Transcription;
KW   Transcription regulation; Two-component regulatory system.
FT   CHAIN           1..251
FT                   /note="Uncharacterized response regulatory protein
FT                   SERP2406"
FT                   /id="PRO_0000299118"
FT   DOMAIN          3..118
FT                   /note="Response regulatory"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00169"
FT   DOMAIN          152..249
FT                   /note="HTH araC/xylS-type"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00593"
FT   DNA_BIND        169..190
FT                   /note="H-T-H motif"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00593"
FT   DNA_BIND        216..239
FT                   /note="H-T-H motif"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00593"
FT   MOD_RES         55
FT                   /note="4-aspartylphosphate"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00169"
SQ   SEQUENCE   251 AA;  29923 MW;  88CE6FE177301C35 CRC64;
     MFKVIICDDE RIIREGLKQM VPWEDYHFTT VYTAKDGVEA LSLIRQHQPE LVITDIRMPR
     KNGVDLLDDI KDLDCQIIIL SSYDDFEYMK AGIQHHVLDY LLKPVDHTQL EHILDILVQR
     LLERPHSTND DAAYHTAFQP LLKIDYDDYY VNQILSQIKQ HYHKKVTVLD LINPIDVSES
     YAMRTFKEHV GITIVDYLNR YRILKSLHLL DQHYKHYEIA EKVGFSEYKM FCYHFKKYLH
     MSPSDYNKQS K