Y2407_MYCS2
ID Y2407_MYCS2 Reviewed; 283 AA.
AC A0QV09; I7G850;
DT 28-JUL-2009, integrated into UniProtKB/Swiss-Prot.
DT 09-JAN-2007, sequence version 1.
DT 03-AUG-2022, entry version 99.
DE RecName: Full=Uncharacterized oxidoreductase MSMEG_2407/MSMEI_2346;
DE EC=1.-.-.-;
GN OrderedLocusNames=MSMEG_2407, MSMEI_2346;
OS Mycolicibacterium smegmatis (strain ATCC 700084 / mc(2)155) (Mycobacterium
OS smegmatis).
OC Bacteria; Actinobacteria; Corynebacteriales; Mycobacteriaceae;
OC Mycolicibacterium.
OX NCBI_TaxID=246196;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=ATCC 700084 / mc(2)155;
RA Fleischmann R.D., Dodson R.J., Haft D.H., Merkel J.S., Nelson W.C.,
RA Fraser C.M.;
RL Submitted (OCT-2006) to the EMBL/GenBank/DDBJ databases.
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=ATCC 700084 / mc(2)155;
RX PubMed=17295914; DOI=10.1186/gb-2007-8-2-r20;
RA Deshayes C., Perrodou E., Gallien S., Euphrasie D., Schaeffer C.,
RA Van-Dorsselaer A., Poch O., Lecompte O., Reyrat J.-M.;
RT "Interrupted coding sequences in Mycobacterium smegmatis: authentic
RT mutations or sequencing errors?";
RL Genome Biol. 8:R20.1-R20.9(2007).
RN [3]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=ATCC 700084 / mc(2)155;
RX PubMed=18955433; DOI=10.1101/gr.081901.108;
RA Gallien S., Perrodou E., Carapito C., Deshayes C., Reyrat J.-M.,
RA Van Dorsselaer A., Poch O., Schaeffer C., Lecompte O.;
RT "Ortho-proteogenomics: multiple proteomes investigation through orthology
RT and a new MS-based protocol.";
RL Genome Res. 19:128-135(2009).
CC -!- SIMILARITY: Belongs to the aldo/keto reductase family. {ECO:0000305}.
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DR EMBL; CP000480; ABK75625.1; -; Genomic_DNA.
DR EMBL; CP001663; AFP38814.1; -; Genomic_DNA.
DR RefSeq; WP_003893772.1; NZ_SIJM01000012.1.
DR RefSeq; YP_886747.1; NC_008596.1.
DR PDB; 2WZM; X-ray; 1.64 A; A/B=1-283.
DR PDB; 2WZT; X-ray; 1.90 A; A/B=1-283.
DR PDBsum; 2WZM; -.
DR PDBsum; 2WZT; -.
DR AlphaFoldDB; A0QV09; -.
DR SMR; A0QV09; -.
DR STRING; 246196.MSMEI_2346; -.
DR EnsemblBacteria; ABK75625; ABK75625; MSMEG_2407.
DR EnsemblBacteria; AFP38814; AFP38814; MSMEI_2346.
DR GeneID; 66733821; -.
DR KEGG; msg:MSMEI_2346; -.
DR KEGG; msm:MSMEG_2407; -.
DR PATRIC; fig|246196.19.peg.2372; -.
DR eggNOG; COG0656; Bacteria.
DR OMA; KLWPTDQ; -.
DR OrthoDB; 1035565at2; -.
DR EvolutionaryTrace; A0QV09; -.
DR PRO; PR:A0QV09; -.
DR Proteomes; UP000000757; Chromosome.
DR Proteomes; UP000006158; Chromosome.
DR GO; GO:0016491; F:oxidoreductase activity; IEA:UniProtKB-KW.
DR Gene3D; 3.20.20.100; -; 1.
DR InterPro; IPR020471; AKR.
DR InterPro; IPR018170; Aldo/ket_reductase_CS.
DR InterPro; IPR023210; NADP_OxRdtase_dom.
DR InterPro; IPR036812; NADP_OxRdtase_dom_sf.
DR PANTHER; PTHR43827; PTHR43827; 1.
DR Pfam; PF00248; Aldo_ket_red; 1.
DR PIRSF; PIRSF000097; AKR; 1.
DR PRINTS; PR00069; ALDKETRDTASE.
DR SUPFAM; SSF51430; SSF51430; 1.
DR PROSITE; PS00798; ALDOKETO_REDUCTASE_1; 1.
DR PROSITE; PS00062; ALDOKETO_REDUCTASE_2; 1.
PE 1: Evidence at protein level;
KW 3D-structure; Oxidoreductase; Reference proteome.
FT CHAIN 1..283
FT /note="Uncharacterized oxidoreductase
FT MSMEG_2407/MSMEI_2346"
FT /id="PRO_0000380740"
FT ACT_SITE 58
FT /note="Proton donor"
FT /evidence="ECO:0000250"
FT BINDING 116
FT /ligand="substrate"
FT /evidence="ECO:0000250"
FT BINDING 196..248
FT /ligand="NADP(+)"
FT /ligand_id="ChEBI:CHEBI:58349"
FT /evidence="ECO:0000250"
FT STRAND 13..15
FT /evidence="ECO:0007829|PDB:2WZM"
FT STRAND 21..28
FT /evidence="ECO:0007829|PDB:2WZM"
FT HELIX 34..47
FT /evidence="ECO:0007829|PDB:2WZM"
FT STRAND 51..53
FT /evidence="ECO:0007829|PDB:2WZM"
FT HELIX 56..58
FT /evidence="ECO:0007829|PDB:2WZM"
FT HELIX 61..70
FT /evidence="ECO:0007829|PDB:2WZM"
FT HELIX 75..77
FT /evidence="ECO:0007829|PDB:2WZM"
FT STRAND 79..84
FT /evidence="ECO:0007829|PDB:2WZM"
FT HELIX 86..88
FT /evidence="ECO:0007829|PDB:2WZM"
FT HELIX 91..105
FT /evidence="ECO:0007829|PDB:2WZM"
FT STRAND 110..115
FT /evidence="ECO:0007829|PDB:2WZM"
FT HELIX 122..137
FT /evidence="ECO:0007829|PDB:2WZM"
FT STRAND 140..148
FT /evidence="ECO:0007829|PDB:2WZM"
FT HELIX 151..161
FT /evidence="ECO:0007829|PDB:2WZM"
FT STRAND 166..171
FT /evidence="ECO:0007829|PDB:2WZM"
FT HELIX 179..187
FT /evidence="ECO:0007829|PDB:2WZM"
FT STRAND 191..195
FT /evidence="ECO:0007829|PDB:2WZM"
FT TURN 197..201
FT /evidence="ECO:0007829|PDB:2WZM"
FT HELIX 202..205
FT /evidence="ECO:0007829|PDB:2WZM"
FT HELIX 207..216
FT /evidence="ECO:0007829|PDB:2WZM"
FT HELIX 220..230
FT /evidence="ECO:0007829|PDB:2WZM"
FT STRAND 234..237
FT /evidence="ECO:0007829|PDB:2WZM"
FT HELIX 242..249
FT /evidence="ECO:0007829|PDB:2WZM"
FT HELIX 258..265
FT /evidence="ECO:0007829|PDB:2WZM"
FT TURN 277..279
FT /evidence="ECO:0007829|PDB:2WZM"
SQ SEQUENCE 283 AA; 29949 MW; AAB705FAF238C089 CRC64;
MTASHGQAAA IPTVTLNDDN TLPVVGIGVG ELSDSEAERS VSAALEAGYR LIDTAAAYGN
EAAVGRAIAA SGIPRDEIYV TTKLATPDQG FTSSQAAARA SLERLGLDYV DLYLIHWPGG
DTSKYVDSWG GLMKVKEDGI ARSIGVCNFG AEDLETIVSL TYFTPAVNQI ELHPLLNQAA
LREVNAGYNI VTEAYGPLGV GRLLDHPAVT AIAEAHGRTA AQVLLRWSIQ LGNVVISRSA
NPERIASNLD VFGFELTADE METLNGLDDG TRFRPDPATY TGS
