ID   Y2409_STAAS             Reviewed;         223 AA.
AC   Q6G6F2;
DT   06-FEB-2007, integrated into UniProtKB/Swiss-Prot.
DT   19-JUL-2004, sequence version 1.
DT   25-MAY-2022, entry version 84.
DE   RecName: Full=Putative NAD(P)H nitroreductase SAS2409;
DE            EC=1.-.-.-;
GN   OrderedLocusNames=SAS2409;
OS   Staphylococcus aureus (strain MSSA476).
OC   Bacteria; Firmicutes; Bacilli; Bacillales; Staphylococcaceae;
OC   Staphylococcus.
OX   NCBI_TaxID=282459;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=MSSA476;
RX   PubMed=15213324; DOI=10.1073/pnas.0402521101;
RA   Holden M.T.G., Feil E.J., Lindsay J.A., Peacock S.J., Day N.P.J.,
RA   Enright M.C., Foster T.J., Moore C.E., Hurst L., Atkin R., Barron A.,
RA   Bason N., Bentley S.D., Chillingworth C., Chillingworth T., Churcher C.,
RA   Clark L., Corton C., Cronin A., Doggett J., Dowd L., Feltwell T., Hance Z.,
RA   Harris B., Hauser H., Holroyd S., Jagels K., James K.D., Lennard N.,
RA   Line A., Mayes R., Moule S., Mungall K., Ormond D., Quail M.A.,
RA   Rabbinowitsch E., Rutherford K.M., Sanders M., Sharp S., Simmonds M.,
RA   Stevens K., Whitehead S., Barrell B.G., Spratt B.G., Parkhill J.;
RT   "Complete genomes of two clinical Staphylococcus aureus strains: evidence
RT   for the rapid evolution of virulence and drug resistance.";
RL   Proc. Natl. Acad. Sci. U.S.A. 101:9786-9791(2004).
CC   -!- COFACTOR:
CC       Name=FMN; Xref=ChEBI:CHEBI:58210; Evidence={ECO:0000305};
CC   -!- SIMILARITY: Belongs to the nitroreductase family. {ECO:0000305}.
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DR   EMBL; BX571857; CAG44224.1; -; Genomic_DNA.
DR   RefSeq; WP_000069098.1; NC_002953.3.
DR   AlphaFoldDB; Q6G6F2; -.
DR   SMR; Q6G6F2; -.
DR   KEGG; sas:SAS2409; -.
DR   HOGENOM; CLU_070764_4_1_9; -.
DR   OMA; PWHFVVA; -.
DR   GO; GO:0016491; F:oxidoreductase activity; IEA:UniProtKB-KW.
DR   CDD; cd02149; NfsB-like; 1.
DR   Gene3D; 3.40.109.10; -; 1.
DR   InterPro; IPR033878; NfsB-like.
DR   InterPro; IPR029479; Nitroreductase.
DR   InterPro; IPR000415; Nitroreductase-like.
DR   Pfam; PF00881; Nitroreductase; 1.
DR   SUPFAM; SSF55469; SSF55469; 1.
PE   3: Inferred from homology;
KW   Flavoprotein; FMN; NAD; NADP; Oxidoreductase.
FT   CHAIN           1..223
FT                   /note="Putative NAD(P)H nitroreductase SAS2409"
FT                   /id="PRO_0000277533"
SQ   SEQUENCE   223 AA;  25375 MW;  86CFC18027E2FCB6 CRC64;
     MSNMNQTIMD AFHFRHATKQ FDPQKKVSKE DFETILESGR LSPSSLGLEP WKFVVIQDQA
     LRDELKAHSW GAAKQLDTAS HFVLIFARKN VTSRSPYVQH MLRDIKKYEA QTIPAVEQKF
     DAFQADFHIS DNDQALYDWS SKQTYIALGN MMTTAALLGI DSCPMEGFSL DTVTDILANK
     GILDTEQFGL SVMVAFGYRQ QDPPKNKTRQ AYEDVIEWVG PKE