Y2412_DICDI
ID Y2412_DICDI Reviewed; 648 AA.
AC Q54DA4;
DT 22-SEP-2009, integrated into UniProtKB/Swiss-Prot.
DT 24-MAY-2005, sequence version 1.
DT 25-MAY-2022, entry version 75.
DE RecName: Full=Putative potassium transport protein DDB_G0292412;
GN ORFNames=DDB_G0292412;
OS Dictyostelium discoideum (Slime mold).
OC Eukaryota; Amoebozoa; Evosea; Eumycetozoa; Dictyostelia; Dictyosteliales;
OC Dictyosteliaceae; Dictyostelium.
OX NCBI_TaxID=44689;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=AX4;
RX PubMed=15875012; DOI=10.1038/nature03481;
RA Eichinger L., Pachebat J.A., Gloeckner G., Rajandream M.A., Sucgang R.,
RA Berriman M., Song J., Olsen R., Szafranski K., Xu Q., Tunggal B.,
RA Kummerfeld S., Madera M., Konfortov B.A., Rivero F., Bankier A.T.,
RA Lehmann R., Hamlin N., Davies R., Gaudet P., Fey P., Pilcher K., Chen G.,
RA Saunders D., Sodergren E.J., Davis P., Kerhornou A., Nie X., Hall N.,
RA Anjard C., Hemphill L., Bason N., Farbrother P., Desany B., Just E.,
RA Morio T., Rost R., Churcher C.M., Cooper J., Haydock S., van Driessche N.,
RA Cronin A., Goodhead I., Muzny D.M., Mourier T., Pain A., Lu M., Harper D.,
RA Lindsay R., Hauser H., James K.D., Quiles M., Madan Babu M., Saito T.,
RA Buchrieser C., Wardroper A., Felder M., Thangavelu M., Johnson D.,
RA Knights A., Loulseged H., Mungall K.L., Oliver K., Price C., Quail M.A.,
RA Urushihara H., Hernandez J., Rabbinowitsch E., Steffen D., Sanders M.,
RA Ma J., Kohara Y., Sharp S., Simmonds M.N., Spiegler S., Tivey A.,
RA Sugano S., White B., Walker D., Woodward J.R., Winckler T., Tanaka Y.,
RA Shaulsky G., Schleicher M., Weinstock G.M., Rosenthal A., Cox E.C.,
RA Chisholm R.L., Gibbs R.A., Loomis W.F., Platzer M., Kay R.R.,
RA Williams J.G., Dear P.H., Noegel A.A., Barrell B.G., Kuspa A.;
RT "The genome of the social amoeba Dictyostelium discoideum.";
RL Nature 435:43-57(2005).
RN [2]
RP INDUCTION [LARGE SCALE ANALYSIS].
RX PubMed=18559084; DOI=10.1186/1471-2164-9-291;
RA Sillo A., Bloomfield G., Balest A., Balbo A., Pergolizzi B., Peracino B.,
RA Skelton J., Ivens A., Bozzaro S.;
RT "Genome-wide transcriptional changes induced by phagocytosis or growth on
RT bacteria in Dictyostelium.";
RL BMC Genomics 9:291-291(2008).
CC -!- FUNCTION: May function as a potassium transporter.
CC -!- SUBCELLULAR LOCATION: Membrane {ECO:0000305}; Multi-pass membrane
CC protein {ECO:0000305}.
CC -!- INDUCTION: Up-regulated by phagocytic stimuli.
CC {ECO:0000269|PubMed:18559084}.
CC -!- SIMILARITY: Belongs to the TrkH potassium transport family.
CC {ECO:0000305}.
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DR EMBL; AAFI02000190; EAL61185.1; -; Genomic_DNA.
DR RefSeq; XP_629592.1; XM_629590.1.
DR AlphaFoldDB; Q54DA4; -.
DR STRING; 44689.DDB0304394; -.
DR PaxDb; Q54DA4; -.
DR EnsemblProtists; EAL61185; EAL61185; DDB_G0292412.
DR GeneID; 8628652; -.
DR KEGG; ddi:DDB_G0292412; -.
DR dictyBase; DDB_G0292412; -.
DR eggNOG; KOG1341; Eukaryota.
DR HOGENOM; CLU_423027_0_0_1; -.
DR InParanoid; Q54DA4; -.
DR OMA; FILEMNI; -.
DR PhylomeDB; Q54DA4; -.
DR PRO; PR:Q54DA4; -.
DR Proteomes; UP000002195; Chromosome 6.
DR GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR GO; GO:0005886; C:plasma membrane; IBA:GO_Central.
DR GO; GO:0008324; F:cation transmembrane transporter activity; IBA:GO_Central.
DR GO; GO:0140107; F:high-affinity potassium ion transmembrane transporter activity; IBA:GO_Central.
DR GO; GO:0030007; P:cellular potassium ion homeostasis; IBA:GO_Central.
DR GO; GO:1990573; P:potassium ion import across plasma membrane; IBA:GO_Central.
DR InterPro; IPR003445; Cat_transpt.
DR Pfam; PF02386; TrkH; 1.
PE 2: Evidence at transcript level;
KW Coiled coil; Glycoprotein; Ion transport; Membrane; Potassium;
KW Potassium transport; Reference proteome; Transmembrane;
KW Transmembrane helix; Transport.
FT CHAIN 1..648
FT /note="Putative potassium transport protein DDB_G0292412"
FT /id="PRO_0000385372"
FT TRANSMEM 48..68
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 313..333
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 353..373
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 385..405
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 443..463
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 472..491
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 505..525
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 550..570
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 571..591
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 592..612
FT /note="Helical"
FT /evidence="ECO:0000255"
FT REGION 106..145
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 223..261
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COILED 199..227
FT /evidence="ECO:0000255"
FT COMPBIAS 114..128
FT /note="Acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 129..145
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT CARBOHYD 81
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
FT CARBOHYD 239
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
FT CARBOHYD 243
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
FT CARBOHYD 247
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
FT CARBOHYD 248
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
FT CARBOHYD 254
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
FT CARBOHYD 257
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
FT CARBOHYD 536
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
SQ SEQUENCE 648 AA; 73510 MW; 32A77CDEDE84E505 CRC64;
MVGFIGSVLI KLIEFEVPFI DCLYIGYSAL TTTGLVTVDI SGWSSGTLFL LVILVQLGST
VLLTLPIVLL RRFFIRSVYS NSSIISAANA SPDLISTIIH SHLPHHDFKD DDDENDNNNN
EENDDNDDES YQHNNNNNEE HDDNDIEIGG ILKLDSPIDH NLPNGFQDDN APHHYNIPIV
GKIDKKSRKF SLDSPSSPII QQQQQQQQQQ QQQQQQQQQQ QQQQQQQPST TTTTTTTTNS
TLNKSTNNST NNNNNTNDSQ SIQKEVNIDI NRIDSLQELQ EQQEHQQQQR QLSKPLNLNS
YEDNMEYRSL GKLLVIIPCY IITIYILGFI SIGAYIAGSE SARSIMKANG VNGWWWSLFH
TFSAFNNAGL ALFSDSLIQI NEKYFLLITL SILIFLGNTL FPVFLRIILL VVSKFTKDPE
PYRNLLENPR SIFTHLFPYK ETVQLFVIWC IFNVSQIALM ALLDVNDKAF TNMNYGTILL
NYYFSSISTR TCGFNSVDLN LLSESVLLLF VGLMFVSSYP FIISLRRSAV NNKYSNQSRE
VMKEVLIRDI FVPYICILFI AIFESQLLES GVITVFQILF EAISAFGNVG LSISITLSTY
SKLVFIALML AGKHRQLPES VDESVNPALL KKNAVISKII TRYKRRKL
