ID   Y2417_MYCTU             Reviewed;         280 AA.
AC   P9WP05; L0TB58; P67368; P71726;
DT   16-APR-2014, integrated into UniProtKB/Swiss-Prot.
DT   16-APR-2014, sequence version 1.
DT   03-AUG-2022, entry version 33.
DE   RecName: Full=DegV domain-containing protein Rv2417c;
GN   OrderedLocusNames=Rv2417c; ORFNames=MTCY253.03;
OS   Mycobacterium tuberculosis (strain ATCC 25618 / H37Rv).
OC   Bacteria; Actinobacteria; Corynebacteriales; Mycobacteriaceae;
OC   Mycobacterium; Mycobacterium tuberculosis complex.
OX   NCBI_TaxID=83332;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=ATCC 25618 / H37Rv;
RX   PubMed=9634230; DOI=10.1038/31159;
RA   Cole S.T., Brosch R., Parkhill J., Garnier T., Churcher C.M., Harris D.E.,
RA   Gordon S.V., Eiglmeier K., Gas S., Barry C.E. III, Tekaia F., Badcock K.,
RA   Basham D., Brown D., Chillingworth T., Connor R., Davies R.M., Devlin K.,
RA   Feltwell T., Gentles S., Hamlin N., Holroyd S., Hornsby T., Jagels K.,
RA   Krogh A., McLean J., Moule S., Murphy L.D., Oliver S., Osborne J.,
RA   Quail M.A., Rajandream M.A., Rogers J., Rutter S., Seeger K., Skelton S.,
RA   Squares S., Squares R., Sulston J.E., Taylor K., Whitehead S.,
RA   Barrell B.G.;
RT   "Deciphering the biology of Mycobacterium tuberculosis from the complete
RT   genome sequence.";
RL   Nature 393:537-544(1998).
RN   [2]
RP   IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
RC   STRAIN=ATCC 25618 / H37Rv;
RX   PubMed=21969609; DOI=10.1074/mcp.m111.011627;
RA   Kelkar D.S., Kumar D., Kumar P., Balakrishnan L., Muthusamy B., Yadav A.K.,
RA   Shrivastava P., Marimuthu A., Anand S., Sundaram H., Kingsbury R.,
RA   Harsha H.C., Nair B., Prasad T.S., Chauhan D.S., Katoch K., Katoch V.M.,
RA   Kumar P., Chaerkady R., Ramachandran S., Dash D., Pandey A.;
RT   "Proteogenomic analysis of Mycobacterium tuberculosis by high resolution
RT   mass spectrometry.";
RL   Mol. Cell. Proteomics 10:M111.011627-M111.011627(2011).
CC   -!- FUNCTION: May bind long-chain fatty acids, such as palmitate, and may
CC       play a role in lipid transport or fatty acid metabolism. {ECO:0000250}.
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DR   EMBL; AL123456; CCP45208.1; -; Genomic_DNA.
DR   PIR; D70685; D70685.
DR   RefSeq; NP_216933.1; NC_000962.3.
DR   RefSeq; WP_003412381.1; NZ_NVQJ01000054.1.
DR   AlphaFoldDB; P9WP05; -.
DR   SMR; P9WP05; -.
DR   STRING; 83332.Rv2417c; -.
DR   PaxDb; P9WP05; -.
DR   DNASU; 885692; -.
DR   GeneID; 45426404; -.
DR   GeneID; 885692; -.
DR   KEGG; mtu:Rv2417c; -.
DR   TubercuList; Rv2417c; -.
DR   eggNOG; COG1307; Bacteria.
DR   OMA; MALGFCA; -.
DR   PhylomeDB; P9WP05; -.
DR   Proteomes; UP000001584; Chromosome.
DR   GO; GO:0005886; C:plasma membrane; HDA:MTBBASE.
DR   GO; GO:0008289; F:lipid binding; IEA:UniProtKB-KW.
DR   Gene3D; 3.30.1180.10; -; 1.
DR   InterPro; IPR003797; DegV.
DR   InterPro; IPR043168; DegV_C.
DR   Pfam; PF02645; DegV; 1.
DR   TIGRFAMs; TIGR00762; DegV; 1.
DR   PROSITE; PS51482; DEGV; 1.
PE   1: Evidence at protein level;
KW   Lipid-binding; Reference proteome.
FT   CHAIN           1..280
FT                   /note="DegV domain-containing protein Rv2417c"
FT                   /id="PRO_0000209778"
FT   DOMAIN          3..274
FT                   /note="DegV"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00815"
FT   BINDING         89
FT                   /ligand="hexadecanoate"
FT                   /ligand_id="ChEBI:CHEBI:7896"
FT                   /evidence="ECO:0000250|UniProtKB:Q9X1H9"
SQ   SEQUENCE   280 AA;  28488 MW;  026303E1BDDFB09E CRC64;
     MTVVVVTDTS CRLPADLREQ WSIRQVPLHI LLDGLDLRDG VDEIPDDIHK RHATTAGATP
     VELSAAYQRA LADSGGDGVV AVHISSALSG TFRAAELTAA ELGPAVRVID SRSAAMGVGF
     AALAAGRAAA AGDELDTVAR AAAAAVSRIH AFVAVARLDN LRRSGRISGA KAWLGTALAL
     KPLLSVDDGK LVLVQRVRTV SNATAVMIDR VCQLVGDRPA ALAVHHVADP AAANDVAAAL
     AERLPACEPA MVTAMGPVLA LHVGAGAVGV CVDVGASPPA