ID   Y241_ATV                Reviewed;         241 AA.
AC   Q3V4T7;
DT   24-NOV-2009, integrated into UniProtKB/Swiss-Prot.
DT   11-OCT-2005, sequence version 1.
DT   02-JUN-2021, entry version 47.
DE   RecName: Full=Putative integrase ORF241;
OS   Acidianus two-tailed virus (ATV).
OC   Viruses; Bicaudaviridae; Bicaudavirus.
OX   NCBI_TaxID=315953;
OH   NCBI_TaxID=269667; Acidianus convivator.
RN   [1]
RP   NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RX   PubMed=16121167; DOI=10.1038/4361101a;
RA   Haring M., Vestergaard G., Rachel R., Chen L., Garrett R.A.,
RA   Prangishvili D.;
RT   "Virology: independent virus development outside a host.";
RL   Nature 436:1101-1102(2005).
CC   -!- FUNCTION: This protein may encode an integrase, which is necessary for
CC       integration of the viral DNA into host genome. {ECO:0000250}.
CC   -!- SIMILARITY: Belongs to the 'phage' integrase family. {ECO:0000305}.
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DR   EMBL; AJ888457; CAI59877.1; -; Genomic_DNA.
DR   RefSeq; YP_319903.1; NC_007409.1.
DR   GeneID; 4484279; -.
DR   KEGG; vg:4484279; -.
DR   Proteomes; UP000002150; Genome.
DR   GO; GO:0003677; F:DNA binding; IEA:InterPro.
DR   GO; GO:0015074; P:DNA integration; IEA:UniProtKB-KW.
DR   GO; GO:0006310; P:DNA recombination; IEA:UniProtKB-KW.
DR   GO; GO:0075713; P:establishment of integrated proviral latency; IEA:UniProtKB-KW.
DR   GO; GO:0046718; P:viral entry into host cell; IEA:UniProtKB-KW.
DR   GO; GO:0044826; P:viral genome integration into host DNA; IEA:UniProtKB-KW.
DR   Gene3D; 1.10.443.10; -; 1.
DR   InterPro; IPR011010; DNA_brk_join_enz.
DR   InterPro; IPR013762; Integrase-like_cat_sf.
DR   InterPro; IPR002104; Integrase_catalytic.
DR   SUPFAM; SSF56349; SSF56349; 1.
DR   PROSITE; PS51898; TYR_RECOMBINASE; 1.
PE   3: Inferred from homology;
KW   DNA integration; DNA recombination; Reference proteome;
KW   Viral genome integration; Virus entry into host cell.
FT   CHAIN           1..241
FT                   /note="Putative integrase ORF241"
FT                   /id="PRO_0000389032"
FT   DOMAIN          82..241
FT                   /note="Tyr recombinase"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU01246"
FT   ACT_SITE        119
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU01246"
FT   ACT_SITE        144
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU01246"
FT   ACT_SITE        191
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU01246"
FT   ACT_SITE        194
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU01246"
FT   ACT_SITE        217
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU01246"
FT   ACT_SITE        226
FT                   /note="O-(3'-phospho-DNA)-tyrosine intermediate"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU01246"
SQ   SEQUENCE   241 AA;  27790 MW;  68AE6EAE65CF6DF3 CRC64;
     MDKDELKEII KNLPDNSPKI LEYLKLAKEK GWKDIVNMIA QKLGLEEEEK KKTDETDVLK
     KILKPLGKGK IKGTWDYSVD FVEAKKTLVS AYKQLYDTNL MPYEAYVAIL LIQLVNGCRI
     REAIRAFKTF IESGEREFQL QAQKHGNIRF MIIPDVVKKK ATYNAVLTID DEKLSARIRM
     FALHYLKANT HSLRYALISY LAKNGIDPAI IAKITGHKRL DRIITYTQTK DAIEMLRKLA
     D