Y2420_DICDI
ID Y2420_DICDI Reviewed; 360 AA.
AC Q559W3;
DT 23-MAR-2010, integrated into UniProtKB/Swiss-Prot.
DT 24-MAY-2005, sequence version 1.
DT 25-MAY-2022, entry version 65.
DE RecName: Full=Uncharacterized protein DDB_G0272420;
DE Flags: Precursor;
GN ORFNames=DDB_G0272420;
OS Dictyostelium discoideum (Slime mold).
OC Eukaryota; Amoebozoa; Evosea; Eumycetozoa; Dictyostelia; Dictyosteliales;
OC Dictyosteliaceae; Dictyostelium.
OX NCBI_TaxID=44689;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=AX4;
RX PubMed=12097910; DOI=10.1038/nature00847;
RA Gloeckner G., Eichinger L., Szafranski K., Pachebat J.A., Bankier A.T.,
RA Dear P.H., Lehmann R., Baumgart C., Parra G., Abril J.F., Guigo R.,
RA Kumpf K., Tunggal B., Cox E.C., Quail M.A., Platzer M., Rosenthal A.,
RA Noegel A.A.;
RT "Sequence and analysis of chromosome 2 of Dictyostelium discoideum.";
RL Nature 418:79-85(2002).
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=AX4;
RX PubMed=15875012; DOI=10.1038/nature03481;
RA Eichinger L., Pachebat J.A., Gloeckner G., Rajandream M.A., Sucgang R.,
RA Berriman M., Song J., Olsen R., Szafranski K., Xu Q., Tunggal B.,
RA Kummerfeld S., Madera M., Konfortov B.A., Rivero F., Bankier A.T.,
RA Lehmann R., Hamlin N., Davies R., Gaudet P., Fey P., Pilcher K., Chen G.,
RA Saunders D., Sodergren E.J., Davis P., Kerhornou A., Nie X., Hall N.,
RA Anjard C., Hemphill L., Bason N., Farbrother P., Desany B., Just E.,
RA Morio T., Rost R., Churcher C.M., Cooper J., Haydock S., van Driessche N.,
RA Cronin A., Goodhead I., Muzny D.M., Mourier T., Pain A., Lu M., Harper D.,
RA Lindsay R., Hauser H., James K.D., Quiles M., Madan Babu M., Saito T.,
RA Buchrieser C., Wardroper A., Felder M., Thangavelu M., Johnson D.,
RA Knights A., Loulseged H., Mungall K.L., Oliver K., Price C., Quail M.A.,
RA Urushihara H., Hernandez J., Rabbinowitsch E., Steffen D., Sanders M.,
RA Ma J., Kohara Y., Sharp S., Simmonds M.N., Spiegler S., Tivey A.,
RA Sugano S., White B., Walker D., Woodward J.R., Winckler T., Tanaka Y.,
RA Shaulsky G., Schleicher M., Weinstock G.M., Rosenthal A., Cox E.C.,
RA Chisholm R.L., Gibbs R.A., Loomis W.F., Platzer M., Kay R.R.,
RA Williams J.G., Dear P.H., Noegel A.A., Barrell B.G., Kuspa A.;
RT "The genome of the social amoeba Dictyostelium discoideum.";
RL Nature 435:43-57(2005).
RN [3]
RP DEVELOPMENTAL STAGE [LARGE SCALE ANALYSIS].
RX PubMed=12796308; DOI=10.1128/ec.2.3.627-637.2003;
RA Maeda M., Sakamoto H., Iranfar N., Fuller D., Maruo T., Ogihara S.,
RA Morio T., Urushihara H., Tanaka Y., Loomis W.F.;
RT "Changing patterns of gene expression in Dictyostelium prestalk cell
RT subtypes recognized by in situ hybridization with genes from microarray
RT analyses.";
RL Eukaryot. Cell 2:627-637(2003).
RN [4]
RP DEVELOPMENTAL STAGE [LARGE SCALE ANALYSIS].
RX PubMed=15470253; DOI=10.1128/ec.3.5.1241-1248.2004;
RA Maruo T., Sakamoto H., Iranfar N., Fuller D., Morio T., Urushihara H.,
RA Tanaka Y., Maeda M., Loomis W.F.;
RT "Control of cell type proportioning in Dictyostelium discoideum by
RT differentiation-inducing factor as determined by in situ hybridization.";
RL Eukaryot. Cell 3:1241-1248(2004).
CC -!- SUBCELLULAR LOCATION: Membrane {ECO:0000305}; Single-pass type I
CC membrane protein {ECO:0000305}.
CC -!- DEVELOPMENTAL STAGE: Expressed in pstO cells.
CC {ECO:0000269|PubMed:12796308, ECO:0000269|PubMed:15470253}.
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DR EMBL; AAFI02000008; EAL71362.1; -; Genomic_DNA.
DR RefSeq; XP_645221.1; XM_640129.1.
DR AlphaFoldDB; Q559W3; -.
DR STRING; 44689.DDB0229933; -.
DR PaxDb; Q559W3; -.
DR EnsemblProtists; EAL71362; EAL71362; DDB_G0272420.
DR GeneID; 8618391; -.
DR KEGG; ddi:DDB_G0272420; -.
DR dictyBase; DDB_G0272420; -.
DR eggNOG; ENOG502TGMX; Eukaryota.
DR HOGENOM; CLU_925680_0_0_1; -.
DR InParanoid; Q559W3; -.
DR OMA; PFNHYCE; -.
DR PhylomeDB; Q559W3; -.
DR PRO; PR:Q559W3; -.
DR Proteomes; UP000002195; Chromosome 2.
DR GO; GO:0005615; C:extracellular space; IBA:GO_Central.
DR GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR GO; GO:0039706; F:co-receptor binding; IBA:GO_Central.
DR GO; GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.
DR GO; GO:0048019; F:receptor antagonist activity; IBA:GO_Central.
DR GO; GO:0090090; P:negative regulation of canonical Wnt signaling pathway; IBA:GO_Central.
DR InterPro; IPR006796; Dickkopf_N.
DR InterPro; IPR039863; DKK-like.
DR InterPro; IPR000571; Znf_CCCH.
DR PANTHER; PTHR12113; PTHR12113; 1.
DR Pfam; PF04706; Dickkopf_N; 1.
DR PROSITE; PS50103; ZF_C3H1; 1.
PE 2: Evidence at transcript level;
KW Glycoprotein; Membrane; Metal-binding; Reference proteome; Signal;
KW Transmembrane; Transmembrane helix; Zinc; Zinc-finger.
FT SIGNAL 1..22
FT /evidence="ECO:0000255"
FT CHAIN 23..360
FT /note="Uncharacterized protein DDB_G0272420"
FT /id="PRO_0000392617"
FT TOPO_DOM 23..339
FT /note="Extracellular"
FT /evidence="ECO:0000255"
FT TRANSMEM 340..360
FT /note="Helical"
FT /evidence="ECO:0000255"
FT ZN_FING 114..140
FT /note="C3H1-type"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00723"
FT REGION 317..336
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT CARBOHYD 126
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
FT CARBOHYD 241
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
SQ SEQUENCE 360 AA; 39715 MW; 96068344218FA0A8 CRC64;
MKNIKIIIIL ISLIFLISIS NSEIFGRSEQ CPLISLLKIG EDCQSSSDCE YPNICKNNKC
QEIVQVGDPC ESDEECGLFF NNIGKCISGT CDINLKNGDD CGEGHSGTCG EGSVCKFYKC
VLNNGNCTSD SQCPFNHYCE ENSNTCSPVV LGNQCDRDSM CPITHICQKN ECVAKYSRET
ATPCGGNPEL CDVFNGDECD KVHKICRRND KYGSECYVDG DCGTGVCMCN NDGHKQCVGS
NTTLVHDGCL QAINSFVKCM KDKRCSSVSP LTCKDCYPIW ECYRYNCFAS EHFDQRKSAY
YKSLKCDTDV GSLVNPDAAN PNYNGGSNRK TNQKRSNSNS NYLISLSLTL TLILILLILF
