ID   Y2422_STAA3             Reviewed;         231 AA.
AC   Q2FE21;
DT   11-SEP-2007, integrated into UniProtKB/Swiss-Prot.
DT   21-MAR-2006, sequence version 1.
DT   03-AUG-2022, entry version 91.
DE   RecName: Full=Uncharacterized oxidoreductase SAUSA300_2422;
DE            EC=1.-.-.-;
GN   OrderedLocusNames=SAUSA300_2422;
OS   Staphylococcus aureus (strain USA300).
OC   Bacteria; Firmicutes; Bacilli; Bacillales; Staphylococcaceae;
OC   Staphylococcus.
OX   NCBI_TaxID=367830;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=USA300;
RX   PubMed=16517273; DOI=10.1016/s0140-6736(06)68231-7;
RA   Diep B.A., Gill S.R., Chang R.F., Phan T.H., Chen J.H., Davidson M.G.,
RA   Lin F., Lin J., Carleton H.A., Mongodin E.F., Sensabaugh G.F.,
RA   Perdreau-Remington F.;
RT   "Complete genome sequence of USA300, an epidemic clone of community-
RT   acquired meticillin-resistant Staphylococcus aureus.";
RL   Lancet 367:731-739(2006).
CC   -!- SIMILARITY: Belongs to the short-chain dehydrogenases/reductases (SDR)
CC       family. {ECO:0000305}.
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DR   EMBL; CP000255; ABD21152.1; -; Genomic_DNA.
DR   RefSeq; WP_000217466.1; NZ_CP027476.1.
DR   AlphaFoldDB; Q2FE21; -.
DR   SMR; Q2FE21; -.
DR   EnsemblBacteria; ABD21152; ABD21152; SAUSA300_2422.
DR   KEGG; saa:SAUSA300_2422; -.
DR   HOGENOM; CLU_010194_2_10_9; -.
DR   OMA; ITGGRNW; -.
DR   Proteomes; UP000001939; Chromosome.
DR   GO; GO:0016491; F:oxidoreductase activity; IEA:UniProtKB-KW.
DR   InterPro; IPR036291; NAD(P)-bd_dom_sf.
DR   InterPro; IPR002347; SDR_fam.
DR   Pfam; PF00106; adh_short; 1.
DR   PRINTS; PR00081; GDHRDH.
DR   PRINTS; PR00080; SDRFAMILY.
DR   SUPFAM; SSF51735; SSF51735; 1.
PE   3: Inferred from homology;
KW   Oxidoreductase.
FT   CHAIN           1..231
FT                   /note="Uncharacterized oxidoreductase SAUSA300_2422"
FT                   /id="PRO_0000300477"
FT   ACT_SITE        153
FT                   /note="Proton acceptor"
FT                   /evidence="ECO:0000250"
FT   BINDING         10..34
FT                   /ligand="NADP(+)"
FT                   /ligand_id="ChEBI:CHEBI:58349"
FT                   /evidence="ECO:0000250"
FT   BINDING         140
FT                   /ligand="substrate"
FT                   /evidence="ECO:0000250"
SQ   SEQUENCE   231 AA;  24604 MW;  189774147ABD5C69 CRC64;
     MTVLTDKVAV VTGAGSGIGE AIATLLHEEG AKVVLAGRNK EKLQNVANQL SQDSVKVVPT
     DVTNKEEVDE LIKIAQQTFG GLDIVINSAG QMLSSKITDY QVDEWDSMID VNIKGTLYTA
     QAALPTMLEQ SSGHLINIAS ISGFEVTKSS TIYSATKAAV HTITQGLEKE LAKTGVKVTS
     ISPGMVDTAI TAAYNPTDRK KLEPQDIAEA VLYALTQPKH VNVNEITVRP V