ID   Y2433_MYCLE             Reviewed;         355 AA.
AC   P54580; Q9CB54;
DT   01-OCT-1996, integrated into UniProtKB/Swiss-Prot.
DT   27-APR-2001, sequence version 2.
DT   25-MAY-2022, entry version 100.
DE   RecName: Full=Uncharacterized protein ML2433;
GN   OrderedLocusNames=ML2433; ORFNames=B2168_C2_209;
OS   Mycobacterium leprae (strain TN).
OC   Bacteria; Actinobacteria; Corynebacteriales; Mycobacteriaceae;
OC   Mycobacterium.
OX   NCBI_TaxID=272631;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RA   Smith D.R., Robison K.;
RL   Submitted (MAR-1994) to the EMBL/GenBank/DDBJ databases.
RN   [2]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=TN;
RX   PubMed=11234002; DOI=10.1038/35059006;
RA   Cole S.T., Eiglmeier K., Parkhill J., James K.D., Thomson N.R.,
RA   Wheeler P.R., Honore N., Garnier T., Churcher C.M., Harris D.E.,
RA   Mungall K.L., Basham D., Brown D., Chillingworth T., Connor R.,
RA   Davies R.M., Devlin K., Duthoy S., Feltwell T., Fraser A., Hamlin N.,
RA   Holroyd S., Hornsby T., Jagels K., Lacroix C., Maclean J., Moule S.,
RA   Murphy L.D., Oliver K., Quail M.A., Rajandream M.A., Rutherford K.M.,
RA   Rutter S., Seeger K., Simon S., Simmonds M., Skelton J., Squares R.,
RA   Squares S., Stevens K., Taylor K., Whitehead S., Woodward J.R.,
RA   Barrell B.G.;
RT   "Massive gene decay in the leprosy bacillus.";
RL   Nature 409:1007-1011(2001).
CC   -!- SUBCELLULAR LOCATION: Cell membrane {ECO:0000305}; Multi-pass membrane
CC       protein {ECO:0000305}.
CC   -!- SIMILARITY: To M.tuberculosis Rv0497. {ECO:0000305}.
CC   -!- SEQUENCE CAUTION:
CC       Sequence=AAA17231.1; Type=Frameshift; Evidence={ECO:0000305};
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DR   EMBL; U00018; AAA17231.1; ALT_FRAME; Genomic_DNA.
DR   EMBL; AL583925; CAC31950.1; -; Genomic_DNA.
DR   PIR; F87213; F87213.
DR   PIR; S72895; S72895.
DR   RefSeq; NP_302577.1; NC_002677.1.
DR   RefSeq; WP_010908896.1; NC_002677.1.
DR   AlphaFoldDB; P54580; -.
DR   STRING; 272631.ML2433; -.
DR   EnsemblBacteria; CAC31950; CAC31950; CAC31950.
DR   KEGG; mle:ML2433; -.
DR   PATRIC; fig|272631.5.peg.4673; -.
DR   Leproma; ML2433; -.
DR   eggNOG; ENOG50348T2; Bacteria.
DR   HOGENOM; CLU_778061_0_0_11; -.
DR   OMA; YWSEPEP; -.
DR   Proteomes; UP000000806; Chromosome.
DR   GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR   GO; GO:0005886; C:plasma membrane; IEA:UniProtKB-SubCell.
PE   4: Predicted;
KW   Cell membrane; Membrane; Reference proteome; Transmembrane;
KW   Transmembrane helix.
FT   CHAIN           1..355
FT                   /note="Uncharacterized protein ML2433"
FT                   /id="PRO_0000103701"
FT   TRANSMEM        275..295
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        301..321
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        330..350
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   CONFLICT        106
FT                   /note="D -> E (in Ref. 1)"
FT                   /evidence="ECO:0000305"
SQ   SEQUENCE   355 AA;  37938 MW;  2A4CB5E317B96A31 CRC64;
     MTGPHNDTES PHARPISVAE LLARNGTIGA PAVSRRRRRR TDSDAVTVAE LTCDIPIIHD
     DHADEQHLAA THAHRANIGV RVVEPAAQSP LEPVCEGIVA EPPVDDHGHV PPGCWSAPEP
     RWPKSPPLTH LRTGLQRSAC SRPLPHLGDV RHPVAPDSIA QKQSDAEGMS PDPVEPFADI
     PVDVMGSEVR AAELVAEESA YARYNLQMSA GALFSGHTLT NELAERRGDE HAAGGLLAVG
     IDLDEDHLDL HTDLAGITSP ARGWQSRFEA LWRGSLIVLQ SILAVVFGAG LFVAFDQLWR
     WNSIVALVLS VLVILGLVVG VRVVRRTEDI ASTLIAVVVG ALITLGPLAL SLQSG