Y2452_ARATH
ID Y2452_ARATH Reviewed; 423 AA.
AC Q9ZQR4; F4IGE5;
DT 27-JUL-2011, integrated into UniProtKB/Swiss-Prot.
DT 27-JUL-2011, sequence version 2.
DT 25-MAY-2022, entry version 106.
DE RecName: Full=DUF21 domain-containing protein At2g14520;
DE AltName: Full=CBS domain-containing protein CBSDUF3;
GN Name=CBSDUF3; OrderedLocusNames=At2g14520; ORFNames=T13P21.10;
OS Arabidopsis thaliana (Mouse-ear cress).
OC Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta;
OC Spermatophyta; Magnoliopsida; eudicotyledons; Gunneridae; Pentapetalae;
OC rosids; malvids; Brassicales; Brassicaceae; Camelineae; Arabidopsis.
OX NCBI_TaxID=3702;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=cv. Columbia;
RX PubMed=10617197; DOI=10.1038/45471;
RA Lin X., Kaul S., Rounsley S.D., Shea T.P., Benito M.-I., Town C.D.,
RA Fujii C.Y., Mason T.M., Bowman C.L., Barnstead M.E., Feldblyum T.V.,
RA Buell C.R., Ketchum K.A., Lee J.J., Ronning C.M., Koo H.L., Moffat K.S.,
RA Cronin L.A., Shen M., Pai G., Van Aken S., Umayam L., Tallon L.J.,
RA Gill J.E., Adams M.D., Carrera A.J., Creasy T.H., Goodman H.M.,
RA Somerville C.R., Copenhaver G.P., Preuss D., Nierman W.C., White O.,
RA Eisen J.A., Salzberg S.L., Fraser C.M., Venter J.C.;
RT "Sequence and analysis of chromosome 2 of the plant Arabidopsis thaliana.";
RL Nature 402:761-768(1999).
RN [2]
RP GENOME REANNOTATION.
RC STRAIN=cv. Columbia;
RX PubMed=27862469; DOI=10.1111/tpj.13415;
RA Cheng C.Y., Krishnakumar V., Chan A.P., Thibaud-Nissen F., Schobel S.,
RA Town C.D.;
RT "Araport11: a complete reannotation of the Arabidopsis thaliana reference
RT genome.";
RL Plant J. 89:789-804(2017).
RN [3]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 105-423.
RC STRAIN=cv. Columbia;
RX PubMed=14593172; DOI=10.1126/science.1088305;
RA Yamada K., Lim J., Dale J.M., Chen H., Shinn P., Palm C.J., Southwick A.M.,
RA Wu H.C., Kim C.J., Nguyen M., Pham P.K., Cheuk R.F., Karlin-Newmann G.,
RA Liu S.X., Lam B., Sakano H., Wu T., Yu G., Miranda M., Quach H.L.,
RA Tripp M., Chang C.H., Lee J.M., Toriumi M.J., Chan M.M., Tang C.C.,
RA Onodera C.S., Deng J.M., Akiyama K., Ansari Y., Arakawa T., Banh J.,
RA Banno F., Bowser L., Brooks S.Y., Carninci P., Chao Q., Choy N., Enju A.,
RA Goldsmith A.D., Gurjal M., Hansen N.F., Hayashizaki Y., Johnson-Hopson C.,
RA Hsuan V.W., Iida K., Karnes M., Khan S., Koesema E., Ishida J., Jiang P.X.,
RA Jones T., Kawai J., Kamiya A., Meyers C., Nakajima M., Narusaka M.,
RA Seki M., Sakurai T., Satou M., Tamse R., Vaysberg M., Wallender E.K.,
RA Wong C., Yamamura Y., Yuan S., Shinozaki K., Davis R.W., Theologis A.,
RA Ecker J.R.;
RT "Empirical analysis of transcriptional activity in the Arabidopsis
RT genome.";
RL Science 302:842-846(2003).
RN [4]
RP GENE FAMILY, AND NOMENCLATURE.
RX PubMed=19400948; DOI=10.1186/1471-2164-10-200;
RA Kushwaha H.R., Singh A.K., Sopory S.K., Singla-Pareek S.L., Pareek A.;
RT "Genome wide expression analysis of CBS domain containing proteins in
RT Arabidopsis thaliana (L.) Heynh and Oryza sativa L. reveals their
RT developmental and stress regulation.";
RL BMC Genomics 10:200-200(2009).
CC -!- SUBCELLULAR LOCATION: Membrane {ECO:0000305}; Multi-pass membrane
CC protein {ECO:0000305}.
CC -!- SEQUENCE CAUTION:
CC Sequence=AAD15464.1; Type=Erroneous gene model prediction; Evidence={ECO:0000305};
CC Sequence=AY080819; Type=Frameshift; Evidence={ECO:0000305};
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DR EMBL; AC006067; AAD15464.1; ALT_SEQ; Genomic_DNA.
DR EMBL; CP002685; AEC06308.1; -; Genomic_DNA.
DR EMBL; CP002685; ANM62035.1; -; Genomic_DNA.
DR EMBL; AY080819; -; NOT_ANNOTATED_CDS; mRNA.
DR PIR; B84518; B84518.
DR RefSeq; NP_001324218.1; NM_001335425.1.
DR RefSeq; NP_179058.3; NM_127015.4.
DR AlphaFoldDB; Q9ZQR4; -.
DR SMR; Q9ZQR4; -.
DR STRING; 3702.AT2G14520.1; -.
DR iPTMnet; Q9ZQR4; -.
DR PaxDb; Q9ZQR4; -.
DR PRIDE; Q9ZQR4; -.
DR EnsemblPlants; AT2G14520.1; AT2G14520.1; AT2G14520.
DR EnsemblPlants; AT2G14520.4; AT2G14520.4; AT2G14520.
DR GeneID; 815939; -.
DR Gramene; AT2G14520.1; AT2G14520.1; AT2G14520.
DR Gramene; AT2G14520.4; AT2G14520.4; AT2G14520.
DR KEGG; ath:AT2G14520; -.
DR Araport; AT2G14520; -.
DR TAIR; locus:2055155; AT2G14520.
DR eggNOG; KOG2118; Eukaryota.
DR HOGENOM; CLU_011310_0_1_1; -.
DR InParanoid; Q9ZQR4; -.
DR OMA; MTHETNQ; -.
DR OrthoDB; 1446644at2759; -.
DR PRO; PR:Q9ZQR4; -.
DR Proteomes; UP000006548; Chromosome 2.
DR ExpressionAtlas; Q9ZQR4; baseline and differential.
DR Genevisible; Q9ZQR4; AT.
DR GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR GO; GO:0043231; C:intracellular membrane-bounded organelle; IBA:GO_Central.
DR GO; GO:0010960; P:magnesium ion homeostasis; IEA:InterPro.
DR CDD; cd04590; CBS_pair_CorC_HlyC_assoc; 1.
DR Gene3D; 3.10.580.10; -; 2.
DR InterPro; IPR045095; ACDP.
DR InterPro; IPR000644; CBS_dom.
DR InterPro; IPR046342; CBS_dom_sf.
DR InterPro; IPR002550; CNNM.
DR InterPro; IPR044751; Ion_transp-like_CBS.
DR PANTHER; PTHR12064; PTHR12064; 1.
DR Pfam; PF01595; DUF21; 1.
DR SUPFAM; SSF54631; SSF54631; 1.
DR PROSITE; PS51371; CBS; 3.
DR PROSITE; PS51846; CNNM; 1.
PE 2: Evidence at transcript level;
KW CBS domain; Glycoprotein; Membrane; Reference proteome; Repeat;
KW Transmembrane; Transmembrane helix.
FT CHAIN 1..423
FT /note="DUF21 domain-containing protein At2g14520"
FT /id="PRO_0000411680"
FT TOPO_DOM 1..11
FT /note="Extracellular"
FT /evidence="ECO:0000255"
FT TRANSMEM 12..32
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TOPO_DOM 33..70
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT TRANSMEM 71..91
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TOPO_DOM 92..94
FT /note="Extracellular"
FT /evidence="ECO:0000255"
FT TRANSMEM 95..115
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TOPO_DOM 116..136
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT TRANSMEM 137..157
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TOPO_DOM 158..423
FT /note="Extracellular"
FT /evidence="ECO:0000255"
FT DOMAIN 8..191
FT /note="CNNM transmembrane"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU01193"
FT DOMAIN 210..271
FT /note="CBS 1"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00703"
FT DOMAIN 275..332
FT /note="CBS 2"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00703"
FT DOMAIN 356..415
FT /note="CBS 3"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00703"
FT CARBOHYD 273
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
FT CARBOHYD 322
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
SQ SEQUENCE 423 AA; 47314 MW; 20C14AB9484AAE6D CRC64;
MAVEYECCGT SFFIHIAVIV LLVLFAGLMS GLTLGLMSMS LVDLEVLAKS GTPRDRIHAA
KILPVVKNQH LLLCTLLICN AAAMEALPIF LDALVTAWGA ILISVTLILL FGEIIPQSVC
SRHGLAIGAT VAPFVRVLVW ICLPVAWPIS KLLDFLLGHG RVALFRRAEL KTLVDLHGNE
AGKGGELTHD ETTIIAGALE LSEKMAKDAM TPISDTFVID INAKLDRDLM NLILDKGHSR
VPVYYEQRTN IIGLVLVKNL LTINPDEEIQ VKNVTIRRIP RVPETLPLYD ILNEFQKGHS
HMAVVVRQCD KIHPLQSNDA ANETVNEVRV DVDYERSPQE TKLKRRRSLQ KWKSFPNRAN
SLGSRSKRWS KDNDADILQL NEHPLPKLDE EEDAVGIITM EDVIEELLQE EIFDETDHHF
EDL
