ID   Y2456_MYCTU             Reviewed;         418 AA.
AC   P9WJX1; L0TB98; O53183; Q7D741;
DT   16-APR-2014, integrated into UniProtKB/Swiss-Prot.
DT   16-APR-2014, sequence version 1.
DT   25-MAY-2022, entry version 37.
DE   RecName: Full=Uncharacterized MFS-type transporter Rv2456c;
GN   OrderedLocusNames=Rv2456c;
OS   Mycobacterium tuberculosis (strain ATCC 25618 / H37Rv).
OC   Bacteria; Actinobacteria; Corynebacteriales; Mycobacteriaceae;
OC   Mycobacterium; Mycobacterium tuberculosis complex.
OX   NCBI_TaxID=83332;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=ATCC 25618 / H37Rv;
RX   PubMed=9634230; DOI=10.1038/31159;
RA   Cole S.T., Brosch R., Parkhill J., Garnier T., Churcher C.M., Harris D.E.,
RA   Gordon S.V., Eiglmeier K., Gas S., Barry C.E. III, Tekaia F., Badcock K.,
RA   Basham D., Brown D., Chillingworth T., Connor R., Davies R.M., Devlin K.,
RA   Feltwell T., Gentles S., Hamlin N., Holroyd S., Hornsby T., Jagels K.,
RA   Krogh A., McLean J., Moule S., Murphy L.D., Oliver S., Osborne J.,
RA   Quail M.A., Rajandream M.A., Rogers J., Rutter S., Seeger K., Skelton S.,
RA   Squares S., Squares R., Sulston J.E., Taylor K., Whitehead S.,
RA   Barrell B.G.;
RT   "Deciphering the biology of Mycobacterium tuberculosis from the complete
RT   genome sequence.";
RL   Nature 393:537-544(1998).
RN   [2]
RP   IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
RC   STRAIN=ATCC 25618 / H37Rv;
RX   PubMed=21969609; DOI=10.1074/mcp.m111.011627;
RA   Kelkar D.S., Kumar D., Kumar P., Balakrishnan L., Muthusamy B., Yadav A.K.,
RA   Shrivastava P., Marimuthu A., Anand S., Sundaram H., Kingsbury R.,
RA   Harsha H.C., Nair B., Prasad T.S., Chauhan D.S., Katoch K., Katoch V.M.,
RA   Kumar P., Chaerkady R., Ramachandran S., Dash D., Pandey A.;
RT   "Proteogenomic analysis of Mycobacterium tuberculosis by high resolution
RT   mass spectrometry.";
RL   Mol. Cell. Proteomics 10:M111.011627-M111.011627(2011).
CC   -!- SUBCELLULAR LOCATION: Cell membrane {ECO:0000305}; Multi-pass membrane
CC       protein {ECO:0000305}.
CC   -!- SIMILARITY: Belongs to the major facilitator superfamily.
CC       {ECO:0000305}.
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DR   EMBL; AL123456; CCP45249.1; -; Genomic_DNA.
DR   PIR; G70864; G70864.
DR   RefSeq; NP_216972.1; NC_000962.3.
DR   RefSeq; WP_003412631.1; NZ_NVQJ01000024.1.
DR   AlphaFoldDB; P9WJX1; -.
DR   SMR; P9WJX1; -.
DR   STRING; 83332.Rv2456c; -.
DR   PaxDb; P9WJX1; -.
DR   DNASU; 887340; -.
DR   GeneID; 887340; -.
DR   KEGG; mtu:Rv2456c; -.
DR   TubercuList; Rv2456c; -.
DR   eggNOG; COG2814; Bacteria.
DR   OMA; ACIVAAQ; -.
DR   PhylomeDB; P9WJX1; -.
DR   Proteomes; UP000001584; Chromosome.
DR   GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR   GO; GO:0005886; C:plasma membrane; IEA:UniProtKB-SubCell.
DR   GO; GO:0022857; F:transmembrane transporter activity; IEA:InterPro.
DR   Gene3D; 1.20.1250.20; -; 2.
DR   InterPro; IPR011701; MFS.
DR   InterPro; IPR020846; MFS_dom.
DR   InterPro; IPR036259; MFS_trans_sf.
DR   Pfam; PF07690; MFS_1; 1.
DR   SUPFAM; SSF103473; SSF103473; 1.
DR   PROSITE; PS50850; MFS; 2.
PE   1: Evidence at protein level;
KW   Cell membrane; Membrane; Reference proteome; Transmembrane;
KW   Transmembrane helix; Transport.
FT   CHAIN           1..418
FT                   /note="Uncharacterized MFS-type transporter Rv2456c"
FT                   /id="PRO_0000390684"
FT   TRANSMEM        51..71
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        79..99
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        110..130
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        163..183
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        224..244
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        258..278
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        289..309
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        315..335
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        356..376
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        379..399
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
SQ   SEQUENCE   418 AA;  43133 MW;  A82674452423CB76 CRC64;
     MSGTVVAVPP RVARALDLLN FSLADVRDGL GPYLSIYLLL IHDWDQASIG FVMAVGGIAA
     IVAQTPIGAL VDRTTAKRAL VVAGAVLVTA AAVAMPLFAG LYSISVLQAV TGIASSVFAP
     ALAAITLGAV GPQFFARRIG RNEAFNHAGN ASAAGATGAL AYFFGPVVVF WVLAGMALIS
     VLATLRIPPD AVDHDLARGM DHAPGEPHPQ PSRFTVLAHN RELVIFGAAV VAFHFANAAM
     LPLVGELLAL HNRDEGTALM SSCIVAAQVV MVPVAYVVGT RADAWGRKPI FLVGFAVLTA
     RGFLYTLSDN SYWLVGVQLL DGIGAGIFGA LFPLVVQDVT HGTGHFNISL GAVTTATGIG
     AALSNLVAGW IVVVAGYDAA FMSLGALAGA GFLLYLVAMP ETVDSDVRVR SRPTLGGK