ID   Y2464_STAAS             Reviewed;         185 AA.
AC   Q6G696;
DT   15-MAY-2007, integrated into UniProtKB/Swiss-Prot.
DT   19-JUL-2004, sequence version 1.
DT   25-MAY-2022, entry version 98.
DE   RecName: Full=HTH-type transcriptional regulator SAS2464;
GN   OrderedLocusNames=SAS2464;
OS   Staphylococcus aureus (strain MSSA476).
OC   Bacteria; Firmicutes; Bacilli; Bacillales; Staphylococcaceae;
OC   Staphylococcus.
OX   NCBI_TaxID=282459;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=MSSA476;
RX   PubMed=15213324; DOI=10.1073/pnas.0402521101;
RA   Holden M.T.G., Feil E.J., Lindsay J.A., Peacock S.J., Day N.P.J.,
RA   Enright M.C., Foster T.J., Moore C.E., Hurst L., Atkin R., Barron A.,
RA   Bason N., Bentley S.D., Chillingworth C., Chillingworth T., Churcher C.,
RA   Clark L., Corton C., Cronin A., Doggett J., Dowd L., Feltwell T., Hance Z.,
RA   Harris B., Hauser H., Holroyd S., Jagels K., James K.D., Lennard N.,
RA   Line A., Mayes R., Moule S., Mungall K., Ormond D., Quail M.A.,
RA   Rabbinowitsch E., Rutherford K.M., Sanders M., Sharp S., Simmonds M.,
RA   Stevens K., Whitehead S., Barrell B.G., Spratt B.G., Parkhill J.;
RT   "Complete genomes of two clinical Staphylococcus aureus strains: evidence
RT   for the rapid evolution of virulence and drug resistance.";
RL   Proc. Natl. Acad. Sci. U.S.A. 101:9786-9791(2004).
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DR   EMBL; BX571857; CAG44280.1; -; Genomic_DNA.
DR   RefSeq; WP_001224187.1; NC_002953.3.
DR   AlphaFoldDB; Q6G696; -.
DR   SMR; Q6G696; -.
DR   KEGG; sas:SAS2464; -.
DR   HOGENOM; CLU_069356_17_2_9; -.
DR   OMA; DAIENRQ; -.
DR   GO; GO:0003677; F:DNA binding; IEA:UniProtKB-KW.
DR   InterPro; IPR023772; DNA-bd_HTH_TetR-type_CS.
DR   InterPro; IPR009057; Homeobox-like_sf.
DR   InterPro; IPR001647; HTH_TetR.
DR   Pfam; PF00440; TetR_N; 1.
DR   PRINTS; PR00455; HTHTETR.
DR   SUPFAM; SSF46689; SSF46689; 1.
DR   PROSITE; PS01081; HTH_TETR_1; 1.
DR   PROSITE; PS50977; HTH_TETR_2; 1.
PE   4: Predicted;
KW   DNA-binding; Transcription; Transcription regulation.
FT   CHAIN           1..185
FT                   /note="HTH-type transcriptional regulator SAS2464"
FT                   /id="PRO_0000286692"
FT   DOMAIN          6..66
FT                   /note="HTH tetR-type"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00335"
FT   DNA_BIND        29..48
FT                   /note="H-T-H motif"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00335"
SQ   SEQUENCE   185 AA;  22332 MW;  B61F5B9B2ECAD14F CRC64;
     MRKDAKENRQ RIEEIAHKLF DEEGVENISM NRIAKELGIG MGTLYRHFKD KSDLCYYVIQ
     RDLDIFITHF KQIKDDYHSN YEVMQVSLDY LLQFKIDNKA LLQCIEAGNN KLRFYQSAFY
     QELFDFYYDL FKSDDDTYTK FKTDMLLQSL STSVFAFQIE HRHISIEAYR NYLLNIYLDE
     VERND