ID   Y246_MYCGE              Reviewed;         281 AA.
AC   P47488;
DT   01-FEB-1996, integrated into UniProtKB/Swiss-Prot.
DT   01-FEB-1996, sequence version 1.
DT   03-AUG-2022, entry version 104.
DE   RecName: Full=Putative phosphatase/phosphodiesterase MG246 {ECO:0000305};
DE            EC=3.1.-.- {ECO:0000305};
GN   OrderedLocusNames=MG246;
OS   Mycoplasma genitalium (strain ATCC 33530 / DSM 19775 / NCTC 10195 / G37)
OS   (Mycoplasmoides genitalium).
OC   Bacteria; Tenericutes; Mollicutes; Mycoplasmataceae; Mycoplasma.
OX   NCBI_TaxID=243273;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=ATCC 33530 / DSM 19775 / NCTC 10195 / G37;
RX   PubMed=7569993; DOI=10.1126/science.270.5235.397;
RA   Fraser C.M., Gocayne J.D., White O., Adams M.D., Clayton R.A.,
RA   Fleischmann R.D., Bult C.J., Kerlavage A.R., Sutton G.G., Kelley J.M.,
RA   Fritchman J.L., Weidman J.F., Small K.V., Sandusky M., Fuhrmann J.L.,
RA   Nguyen D.T., Utterback T.R., Saudek D.M., Phillips C.A., Merrick J.M.,
RA   Tomb J.-F., Dougherty B.A., Bott K.F., Hu P.-C., Lucier T.S.,
RA   Peterson S.N., Smith H.O., Hutchison C.A. III, Venter J.C.;
RT   "The minimal gene complement of Mycoplasma genitalium.";
RL   Science 270:397-403(1995).
CC   -!- COFACTOR:
CC       Name=Fe(3+); Xref=ChEBI:CHEBI:29034;
CC         Evidence={ECO:0000250|UniProtKB:P75429};
CC   -!- SIMILARITY: Belongs to the YmdB-like family. {ECO:0000305}.
CC   ---------------------------------------------------------------------------
CC   Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC   Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC   ---------------------------------------------------------------------------
DR   EMBL; L43967; AAC71466.1; -; Genomic_DNA.
DR   PIR; B64227; B64227.
DR   RefSeq; WP_010869391.1; NC_000908.2.
DR   AlphaFoldDB; P47488; -.
DR   SMR; P47488; -.
DR   STRING; 243273.MG_246; -.
DR   EnsemblBacteria; AAC71466; AAC71466; MG_246.
DR   KEGG; mge:MG_246; -.
DR   eggNOG; COG1692; Bacteria.
DR   HOGENOM; CLU_068238_0_0_14; -.
DR   OMA; NHIWDKK; -.
DR   OrthoDB; 1127353at2; -.
DR   BioCyc; MGEN243273:G1GJ2-293-MON; -.
DR   Proteomes; UP000000807; Chromosome.
DR   GO; GO:0004113; F:2',3'-cyclic-nucleotide 3'-phosphodiesterase activity; IBA:GO_Central.
DR   GO; GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.
DR   Gene3D; 3.60.21.10; -; 1.
DR   InterPro; IPR029052; Metallo-depent_PP-like.
DR   InterPro; IPR005235; YmdB-like.
DR   PANTHER; PTHR36303; PTHR36303; 1.
DR   Pfam; PF13277; YmdB; 1.
DR   PIRSF; PIRSF004789; DR1281; 1.
DR   SUPFAM; SSF56300; SSF56300; 1.
DR   TIGRFAMs; TIGR00282; TIGR00282; 1.
PE   3: Inferred from homology;
KW   Hydrolase; Iron; Metal-binding; Reference proteome.
FT   CHAIN           1..281
FT                   /note="Putative phosphatase/phosphodiesterase MG246"
FT                   /id="PRO_0000210485"
FT   ACT_SITE        71
FT                   /note="Proton donor"
FT                   /evidence="ECO:0000250|UniProtKB:O31775"
FT   BINDING         11
FT                   /ligand="Fe cation"
FT                   /ligand_id="ChEBI:CHEBI:24875"
FT                   /ligand_label="1"
FT                   /evidence="ECO:0000250|UniProtKB:P75429"
FT   BINDING         42
FT                   /ligand="Fe cation"
FT                   /ligand_id="ChEBI:CHEBI:24875"
FT                   /ligand_label="1"
FT                   /evidence="ECO:0000250|UniProtKB:P75429"
FT   BINDING         42
FT                   /ligand="Fe cation"
FT                   /ligand_id="ChEBI:CHEBI:24875"
FT                   /ligand_label="2"
FT                   /evidence="ECO:0000250|UniProtKB:P75429"
FT   BINDING         43
FT                   /ligand="Fe cation"
FT                   /ligand_id="ChEBI:CHEBI:24875"
FT                   /ligand_label="1"
FT                   /evidence="ECO:0000250|UniProtKB:P75429"
FT   BINDING         70
FT                   /ligand="Fe cation"
FT                   /ligand_id="ChEBI:CHEBI:24875"
FT                   /ligand_label="2"
FT                   /evidence="ECO:0000250|UniProtKB:P75429"
FT   BINDING         157
FT                   /ligand="Fe cation"
FT                   /ligand_id="ChEBI:CHEBI:24875"
FT                   /ligand_label="2"
FT                   /evidence="ECO:0000250|UniProtKB:P75429"
FT   BINDING         182
FT                   /ligand="Fe cation"
FT                   /ligand_id="ChEBI:CHEBI:24875"
FT                   /ligand_label="2"
FT                   /evidence="ECO:0000250|UniProtKB:P75429"
FT   BINDING         184
FT                   /ligand="Fe cation"
FT                   /ligand_id="ChEBI:CHEBI:24875"
FT                   /ligand_label="1"
FT                   /evidence="ECO:0000250|UniProtKB:P75429"
SQ   SEQUENCE   281 AA;  31595 MW;  7BC4A993A879ED22 CRC64;
     MDNIKVLFLG DVYGKAGRKI ISDHLPIIKK KYQLNLIIAN AENTTNGKGL SWNHYQILKQ
     AGIDYITMGN HTWFQKQDLE LVLNQVDVIR PLNLMQDFNY FQLGKGSYLF SLNGLKIRIT
     NLLGTSINLP FAITNPFVEL KKLVLTKDCD LHIVDFHAET TSEKNAFCMV FDGYVTAILG
     THTHVPSNDL RITPKGSVYI TDVGMCGPGF GSVIGANPKQ SIKLFCTGER QFFEVSNCGA
     QLNGVFFEVC SKTNQVVKIE QIRIVLDDEK YLANDYFNLV E