ID   Y246_TREPA              Reviewed;         597 AA.
AC   O83274;
DT   01-JUN-2001, integrated into UniProtKB/Swiss-Prot.
DT   01-NOV-1998, sequence version 1.
DT   25-MAY-2022, entry version 87.
DE   RecName: Full=Uncharacterized protein TP_0246;
GN   OrderedLocusNames=TP_0246;
OS   Treponema pallidum (strain Nichols).
OC   Bacteria; Spirochaetes; Spirochaetales; Treponemataceae; Treponema.
OX   NCBI_TaxID=243276;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=Nichols;
RX   PubMed=9665876; DOI=10.1126/science.281.5375.375;
RA   Fraser C.M., Norris S.J., Weinstock G.M., White O., Sutton G.G.,
RA   Dodson R.J., Gwinn M.L., Hickey E.K., Clayton R.A., Ketchum K.A.,
RA   Sodergren E., Hardham J.M., McLeod M.P., Salzberg S.L., Peterson J.D.,
RA   Khalak H.G., Richardson D.L., Howell J.K., Chidambaram M., Utterback T.R.,
RA   McDonald L.A., Artiach P., Bowman C., Cotton M.D., Fujii C., Garland S.A.,
RA   Hatch B., Horst K., Roberts K.M., Sandusky M., Weidman J.F., Smith H.O.,
RA   Venter J.C.;
RT   "Complete genome sequence of Treponema pallidum, the syphilis spirochete.";
RL   Science 281:375-388(1998).
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DR   EMBL; AE000520; AAC65240.1; -; Genomic_DNA.
DR   PIR; A71348; A71348.
DR   AlphaFoldDB; O83274; -.
DR   STRING; 243276.TPANIC_0246; -.
DR   EnsemblBacteria; AAC65240; AAC65240; TP_0246.
DR   KEGG; tpa:TP_0246; -.
DR   eggNOG; COG2304; Bacteria.
DR   HOGENOM; CLU_423186_0_0_12; -.
DR   OMA; NQIMWHI; -.
DR   Proteomes; UP000000811; Chromosome.
DR   Gene3D; 3.40.50.410; -; 1.
DR   InterPro; IPR002035; VWF_A.
DR   InterPro; IPR036465; vWFA_dom_sf.
DR   Pfam; PF00092; VWA; 1.
DR   SMART; SM00327; VWA; 1.
DR   SUPFAM; SSF53300; SSF53300; 1.
DR   PROSITE; PS50234; VWFA; 1.
PE   4: Predicted;
KW   Reference proteome.
FT   CHAIN           1..597
FT                   /note="Uncharacterized protein TP_0246"
FT                   /id="PRO_0000202218"
FT   DOMAIN          378..575
FT                   /note="VWFA"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00219"
SQ   SEQUENCE   597 AA;  69814 MW;  BAF44661C4FDFB4D CRC64;
     MVGVPLQWFL KDDFDGKEIL WNLFRELVYY RELKADYAYY CNRVSFFEDA AQGMRRLMYE
     AVFSREARDE IRVRAFVQHY CHTEVASLFY LFDAVYAFHY VRNRAPYYTT PEGSALLASL
     YQKERGVYWE HTETALHLQF AYALAERVLF HDMPKGCNRA CIARDPVVQE VLRTLVLGTE
     MSNFIHSEFF PLSGEVVPTK HRDRIVSVFL LEHFVRLWHL SVANITFELK NITDRSYDPF
     RNERAFEYTK SNLHAVHSRD GQQELKKRED VFESCTTQFD ERFSISPKER KEFARLLRTT
     HRLRIDMRSF WKSLIGKSVQ WIDCYEGKCP KGRLNVGDFV SVFPDFQEFR GRDQRYKLRV
     YDRVYEVRAC TLRPAQIEVS FVVDNSGSMN KEKIASAREA LAVSMLSLKD FGEYSDMLAA
     GRRERTTIHS EVYYFGSSFI KVKSFGKSKS KDFNSAQLIK ASVNLDGRFG GTNDAEVLKH
     ILADVERRRA RVSSDTSFVK VVLVITDGCS SYPHESRRTI EELRRRGVMI FGFQIGLMSP
     EETALFHDVW NSTEELGLLL GERLEYLPRE LLRTLRVVLS KVHRLSSGER LHAQRVW