ID   Y2471_DICDI             Reviewed;        1508 AA.
AC   Q75JP5; Q559M2;
DT   09-FEB-2010, integrated into UniProtKB/Swiss-Prot.
DT   05-JUL-2004, sequence version 1.
DT   25-MAY-2022, entry version 81.
DE   RecName: Full=Calponin homology domain-containing protein DDB_G0272472;
GN   ORFNames=DDB_G0272472;
OS   Dictyostelium discoideum (Slime mold).
OC   Eukaryota; Amoebozoa; Evosea; Eumycetozoa; Dictyostelia; Dictyosteliales;
OC   Dictyosteliaceae; Dictyostelium.
OX   NCBI_TaxID=44689;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=AX4;
RX   PubMed=12097910; DOI=10.1038/nature00847;
RA   Gloeckner G., Eichinger L., Szafranski K., Pachebat J.A., Bankier A.T.,
RA   Dear P.H., Lehmann R., Baumgart C., Parra G., Abril J.F., Guigo R.,
RA   Kumpf K., Tunggal B., Cox E.C., Quail M.A., Platzer M., Rosenthal A.,
RA   Noegel A.A.;
RT   "Sequence and analysis of chromosome 2 of Dictyostelium discoideum.";
RL   Nature 418:79-85(2002).
RN   [2]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=AX4;
RX   PubMed=15875012; DOI=10.1038/nature03481;
RA   Eichinger L., Pachebat J.A., Gloeckner G., Rajandream M.A., Sucgang R.,
RA   Berriman M., Song J., Olsen R., Szafranski K., Xu Q., Tunggal B.,
RA   Kummerfeld S., Madera M., Konfortov B.A., Rivero F., Bankier A.T.,
RA   Lehmann R., Hamlin N., Davies R., Gaudet P., Fey P., Pilcher K., Chen G.,
RA   Saunders D., Sodergren E.J., Davis P., Kerhornou A., Nie X., Hall N.,
RA   Anjard C., Hemphill L., Bason N., Farbrother P., Desany B., Just E.,
RA   Morio T., Rost R., Churcher C.M., Cooper J., Haydock S., van Driessche N.,
RA   Cronin A., Goodhead I., Muzny D.M., Mourier T., Pain A., Lu M., Harper D.,
RA   Lindsay R., Hauser H., James K.D., Quiles M., Madan Babu M., Saito T.,
RA   Buchrieser C., Wardroper A., Felder M., Thangavelu M., Johnson D.,
RA   Knights A., Loulseged H., Mungall K.L., Oliver K., Price C., Quail M.A.,
RA   Urushihara H., Hernandez J., Rabbinowitsch E., Steffen D., Sanders M.,
RA   Ma J., Kohara Y., Sharp S., Simmonds M.N., Spiegler S., Tivey A.,
RA   Sugano S., White B., Walker D., Woodward J.R., Winckler T., Tanaka Y.,
RA   Shaulsky G., Schleicher M., Weinstock G.M., Rosenthal A., Cox E.C.,
RA   Chisholm R.L., Gibbs R.A., Loomis W.F., Platzer M., Kay R.R.,
RA   Williams J.G., Dear P.H., Noegel A.A., Barrell B.G., Kuspa A.;
RT   "The genome of the social amoeba Dictyostelium discoideum.";
RL   Nature 435:43-57(2005).
RN   [3]
RP   IDENTIFICATION.
RX   PubMed=19779846; DOI=10.1007/s11033-009-9839-1;
RA   Friedberg F., Rivero F.;
RT   "Single and multiple CH (calponin homology) domain containing multidomain
RT   proteins in Dictyostelium discoideum: an inventory.";
RL   Mol. Biol. Rep. 37:2853-2862(2010).
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DR   EMBL; AAFI02000008; EAL71388.1; -; Genomic_DNA.
DR   RefSeq; XP_645312.1; XM_640220.1.
DR   AlphaFoldDB; Q75JP5; -.
DR   SMR; Q75JP5; -.
DR   PaxDb; Q75JP5; -.
DR   EnsemblProtists; EAL71388; EAL71388; DDB_G0272472.
DR   GeneID; 8618478; -.
DR   KEGG; ddi:DDB_G0272472; -.
DR   dictyBase; DDB_G0272472; -.
DR   HOGENOM; CLU_248345_0_0_1; -.
DR   InParanoid; Q75JP5; -.
DR   OMA; GMMMPKF; -.
DR   Reactome; R-DDI-6807878; COPI-mediated anterograde transport.
DR   PRO; PR:Q75JP5; -.
DR   Proteomes; UP000002195; Chromosome 2.
DR   CDD; cd00014; CH; 1.
DR   Gene3D; 1.10.418.10; -; 1.
DR   InterPro; IPR001715; CH-domain.
DR   InterPro; IPR036872; CH_dom_sf.
DR   Pfam; PF00307; CH; 1.
DR   SMART; SM00033; CH; 1.
DR   SUPFAM; SSF47576; SSF47576; 1.
DR   PROSITE; PS50021; CH; 1.
PE   4: Predicted;
KW   Coiled coil; Reference proteome.
FT   CHAIN           1..1508
FT                   /note="Calponin homology domain-containing protein
FT                   DDB_G0272472"
FT                   /id="PRO_0000391604"
FT   DOMAIN          1397..1504
FT                   /note="Calponin-homology (CH)"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00044"
FT   REGION          1..165
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          197..290
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          309..518
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          531..561
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          680..706
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          1036..1391
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COILED          455..498
FT                   /evidence="ECO:0000255"
FT   COMPBIAS        1..16
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        47..113
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        137..154
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        197..219
FT                   /note="Basic and acidic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        236..251
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        265..290
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        309..334
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        347..361
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        375..460
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        461..498
FT                   /note="Basic and acidic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        499..518
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        531..558
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        1036..1166
FT                   /note="Basic and acidic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        1167..1210
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        1250..1275
FT                   /note="Basic and acidic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        1301..1323
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        1330..1377
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   1508 AA;  173965 MW;  3C8661F21658F2AB CRC64;
     MFRNILSWFD STPQPPPQQQ EQQPEQPLEP PKVVSKNEAR ILTDQLPAPD SQRSQRYDRI
     NNNKNNNNSN VDPLGNKDIF SSSPSTSTTT TTKSSSTTTT TTTSSSSNKQ QPLYEDEPPL
     IVHELTSKGK RPPSPIFKEE SSSQLILDTW EINSSDDESN SKNDFKGFMS QLESSNLNEK
     YITSNIYQKY EFFQKRDSEE DLFPSPEPIK KKQSNDLEKN IFDDDDDDDI FKNKQSTVTK
     PKQPQQQQKQ PIVKKKVEEE SLFGDSSLSL DSPLLASKSS PPKSSVNLSP QLFKEDSFDI
     DSFLSNDFDF KSKKSNNTTT VKKAVPISKS KPQQPPQKEE IKEVSTQKDN SNSNNNNGWV
     SVDEKPKERS TSKSKIGIQK TVTVKSNNSF ENDIFGSTTT NDDGGDNDFS FTPATTPSSS
     SSTKATTTSP SSTTTTKSNI NIGQKSNKSV DQADQFLNDI FQQEEQDKKR REEEAKLKQQ
     QKQKEKEQIK DEIDDLFKFS KPTTTTTSTP SKSTTSIVDI NSIEKKFSKS AANATTTNND
     NNNNNNNTSS PTNKSTNLFN DWEKEEEIKV KEELDKKKKI EQEKKLEQEK KLIEEKKRIA
     EEKRISDEIL AKKQLAEKLE KERIEKELED LRLAKELEEK RLLALRQEKE LAEKLKRERL
     EKEAEDKRIA QEIERKRLEK EKQDQLEKQR KLEQQRLQKE KDEKELADRL EKERIENEIK
     EKQKQLEKIK LEKELAEKKE KERLQKEADE KRIADQLEFE RLLKLKQEKE LAEKLEKERL
     EKEAAAEEKR IAAEKLEKQR LEKEAEEKRI AQDLERKRLE KEAEEKRIAQ DLERKRLEKE
     AEEKRIAAEK LKQQQELAAK LEKERLEKEA EEKRIAQEKR IAEENRIAQE KKIAEELEKK
     RLQKEEQDRL AAAELERKRL EKEAEEKRIA QELEKKRLEK EAAEVKRIAD EAAAAAKLEK
     ERLEKEAEEK RIADEAAAAA KLEKERLEKE AAAAEEKRIA DEAAAEAKLE KERLEKEKRI
     ADEAAAEAAA ALLQQKIEKE KEERDRIAKE NKELKEKEDK ERKEQRQRER QEKEQERARA
     LKEKIEKEKE RLNQQKLDQE KEEREREQRE RKEQQEREEN EKQLEKEREE KERREKLKQR
     NEQLEKERQE RFKKDQEEKE KQLKEQQQQQ KVIIPTTTTT TIRERSNSDS DALLNLPDSA
     SSSSHSELVH LTLGRSKAKG RKKPTRRELT KDGNRNKQNI PNLKELKPST VIIPDDDDDQ
     SQKQQSEEVE EKPVAVKKMP IGFNPGMMMP KFDPSAVKLK SSAKPPSTNT TTTTTTAPQQ
     PVQFNLKPVA LKPTVTQTTT TTTTPPTTPP SSSVQLKPAA TRSFSGSSFM GINSTTPTTP
     PTTPPSLKKS AAKDAGMKAL DVLLQWLKDQ TAGYEGVNIK DFTSSWYDGI AYLALVHRFK
     PSLIGDWKSF PKNDRVANYK LAFSLAEKHL GVTAFIDADD LAQLPSMERL SNITYLSEFF
     KVMKRGGF