ID   Y2474_ARATH             Reviewed;         578 AA.
AC   Q9SJ85;
DT   31-MAY-2011, integrated into UniProtKB/Swiss-Prot.
DT   31-MAY-2011, sequence version 2.
DT   03-AUG-2022, entry version 133.
DE   RecName: Full=BTB/POZ domain-containing protein At2g04740;
GN   OrderedLocusNames=At2g04740; ORFNames=F28I8.22;
OS   Arabidopsis thaliana (Mouse-ear cress).
OC   Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta;
OC   Spermatophyta; Magnoliopsida; eudicotyledons; Gunneridae; Pentapetalae;
OC   rosids; malvids; Brassicales; Brassicaceae; Camelineae; Arabidopsis.
OX   NCBI_TaxID=3702;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=cv. Columbia;
RX   PubMed=10617197; DOI=10.1038/45471;
RA   Lin X., Kaul S., Rounsley S.D., Shea T.P., Benito M.-I., Town C.D.,
RA   Fujii C.Y., Mason T.M., Bowman C.L., Barnstead M.E., Feldblyum T.V.,
RA   Buell C.R., Ketchum K.A., Lee J.J., Ronning C.M., Koo H.L., Moffat K.S.,
RA   Cronin L.A., Shen M., Pai G., Van Aken S., Umayam L., Tallon L.J.,
RA   Gill J.E., Adams M.D., Carrera A.J., Creasy T.H., Goodman H.M.,
RA   Somerville C.R., Copenhaver G.P., Preuss D., Nierman W.C., White O.,
RA   Eisen J.A., Salzberg S.L., Fraser C.M., Venter J.C.;
RT   "Sequence and analysis of chromosome 2 of the plant Arabidopsis thaliana.";
RL   Nature 402:761-768(1999).
RN   [2]
RP   GENOME REANNOTATION.
RC   STRAIN=cv. Columbia;
RX   PubMed=27862469; DOI=10.1111/tpj.13415;
RA   Cheng C.Y., Krishnakumar V., Chan A.P., Thibaud-Nissen F., Schobel S.,
RA   Town C.D.;
RT   "Araport11: a complete reannotation of the Arabidopsis thaliana reference
RT   genome.";
RL   Plant J. 89:789-804(2017).
RN   [3]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC   STRAIN=cv. Columbia;
RX   PubMed=14993207; DOI=10.1101/gr.1515604;
RA   Castelli V., Aury J.-M., Jaillon O., Wincker P., Clepet C., Menard M.,
RA   Cruaud C., Quetier F., Scarpelli C., Schaechter V., Temple G., Caboche M.,
RA   Weissenbach J., Salanoubat M.;
RT   "Whole genome sequence comparisons and 'full-length' cDNA sequences: a
RT   combined approach to evaluate and improve Arabidopsis genome annotation.";
RL   Genome Res. 14:406-413(2004).
RN   [4]
RP   DOMAIN BTB.
RX   PubMed=15749712; DOI=10.1074/jbc.m413247200;
RA   Gingerich D.J., Gagne J.M., Salter D.W., Hellmann H., Estelle M., Ma L.,
RA   Vierstra R.D.;
RT   "Cullins 3a and 3b assemble with members of the broad
RT   complex/tramtrack/bric-a-brac (BTB) protein family to form essential
RT   ubiquitin-protein ligases (E3s) in Arabidopsis.";
RL   J. Biol. Chem. 280:18810-18821(2005).
CC   -!- FUNCTION: May act as a substrate-specific adapter of an E3 ubiquitin-
CC       protein ligase complex (CUL3-RBX1-BTB) which mediates the
CC       ubiquitination and subsequent proteasomal degradation of target
CC       proteins. {ECO:0000250}.
CC   -!- PATHWAY: Protein modification; protein ubiquitination.
CC   -!- DOMAIN: The BTB/POZ domain mediates the interaction with some component
CC       of ubiquitin ligase complexes. {ECO:0000269|PubMed:15749712}.
CC   -!- SEQUENCE CAUTION:
CC       Sequence=AAD22332.1; Type=Erroneous gene model prediction; Evidence={ECO:0000305};
CC       Sequence=BX821056; Type=Frameshift; Evidence={ECO:0000305};
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DR   EMBL; AC006955; AAD22332.1; ALT_SEQ; Genomic_DNA.
DR   EMBL; CP002685; AEC05859.1; -; Genomic_DNA.
DR   EMBL; BX821056; -; NOT_ANNOTATED_CDS; mRNA.
DR   PIR; H84460; H84460.
DR   RefSeq; NP_178551.2; NM_126504.4.
DR   AlphaFoldDB; Q9SJ85; -.
DR   SMR; Q9SJ85; -.
DR   BioGRID; 418; 2.
DR   IntAct; Q9SJ85; 2.
DR   STRING; 3702.AT2G04740.1; -.
DR   iPTMnet; Q9SJ85; -.
DR   PaxDb; Q9SJ85; -.
DR   PRIDE; Q9SJ85; -.
DR   ProteomicsDB; 242365; -.
DR   EnsemblPlants; AT2G04740.1; AT2G04740.1; AT2G04740.
DR   GeneID; 815017; -.
DR   Gramene; AT2G04740.1; AT2G04740.1; AT2G04740.
DR   KEGG; ath:AT2G04740; -.
DR   Araport; AT2G04740; -.
DR   TAIR; locus:2049168; AT2G04740.
DR   eggNOG; KOG0511; Eukaryota.
DR   HOGENOM; CLU_022885_1_0_1; -.
DR   InParanoid; Q9SJ85; -.
DR   OMA; EYMYTDR; -.
DR   OrthoDB; 871743at2759; -.
DR   UniPathway; UPA00143; -.
DR   PRO; PR:Q9SJ85; -.
DR   Proteomes; UP000006548; Chromosome 2.
DR   ExpressionAtlas; Q9SJ85; baseline and differential.
DR   Genevisible; Q9SJ85; AT.
DR   GO; GO:0005737; C:cytoplasm; IBA:GO_Central.
DR   GO; GO:0000151; C:ubiquitin ligase complex; IBA:GO_Central.
DR   GO; GO:0042742; P:defense response to bacterium; IEA:UniProt.
DR   GO; GO:0016567; P:protein ubiquitination; IEA:UniProtKB-UniPathway.
DR   Gene3D; 1.25.40.20; -; 1.
DR   Gene3D; 3.30.710.10; -; 2.
DR   InterPro; IPR044515; ABTB1.
DR   InterPro; IPR002110; Ankyrin_rpt.
DR   InterPro; IPR036770; Ankyrin_rpt-contain_sf.
DR   InterPro; IPR000210; BTB/POZ_dom.
DR   InterPro; IPR011333; SKP1/BTB/POZ_sf.
DR   PANTHER; PTHR46231; PTHR46231; 1.
DR   Pfam; PF13637; Ank_4; 1.
DR   Pfam; PF00651; BTB; 2.
DR   SMART; SM00225; BTB; 2.
DR   SUPFAM; SSF48403; SSF48403; 1.
DR   SUPFAM; SSF54695; SSF54695; 2.
DR   PROSITE; PS50297; ANK_REP_REGION; 1.
DR   PROSITE; PS50097; BTB; 2.
PE   2: Evidence at transcript level;
KW   ANK repeat; Reference proteome; Repeat; Ubl conjugation pathway.
FT   CHAIN           1..578
FT                   /note="BTB/POZ domain-containing protein At2g04740"
FT                   /id="PRO_0000408533"
FT   REPEAT          35..64
FT                   /note="ANK 1"
FT   REPEAT          68..97
FT                   /note="ANK 2"
FT   DOMAIN          173..240
FT                   /note="BTB 1"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00037"
FT   DOMAIN          338..414
FT                   /note="BTB 2"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00037"
FT   CONFLICT        28
FT                   /note="P -> Q (in Ref. 3; BX821056)"
FT                   /evidence="ECO:0000305"
SQ   SEQUENCE   578 AA;  66068 MW;  0771D55301E28BAF CRC64;
     MSPIENSSSW TLESDLEDLD LDLQDYKPSV PLKKVPNGDI FEASRAGDVD RLRYLVETGV
     NVNARDRWDS VALYYACLAG HIDSARLLLE NGAICSEHTF DGDRCHYASL NLRIRKLLKA
     FEARPPPLAP LQASLRDTFL GCCHNRDYLQ QEEANLDVSD TLSEFGSSNY FPPDVMFYVQ
     GRPIEAHRVI LSARSPFFKQ KFENEWKDRR EVRFSKEKLS YPALCSLIHF FYSDRLEISV
     DDMEDLVRIC KVCKCESLQK IIEKELIHQR YAEYKTHRDL DNSMKRFILQ GISLPEEDRL
     PASLHRILRV SLAKSFVGDV IDSSVGDTRV GDSVESLADV CVRVDKRNFY CHQVILASRS
     EYFRARLSRV NDFHEGKNGL PGDTLPFLEE HDLSAEAFEK MIEYMYTDGL KEINPNQAEE
     IFDVASRYLL FPLKRAVADA LLPHLETATP AELCQWLVLS DMYGVLKIRE YCLDLVACNF
     EAFVETHEFR AMLLTLPPPS GDSSLRTTVP SAPGAMMTTD QGNLLDDLRE KWLEAEALEL
     DMRDESALIF DKRLAMLVEI AEREKSESEA EDYKDTSA