ID   Y2498_STAAW             Reviewed;         185 AA.
AC   Q79ZX9;
DT   15-MAY-2007, integrated into UniProtKB/Swiss-Prot.
DT   05-JUL-2004, sequence version 1.
DT   25-MAY-2022, entry version 100.
DE   RecName: Full=HTH-type transcriptional regulator MW2498;
GN   OrderedLocusNames=MW2498;
OS   Staphylococcus aureus (strain MW2).
OC   Bacteria; Firmicutes; Bacilli; Bacillales; Staphylococcaceae;
OC   Staphylococcus.
OX   NCBI_TaxID=196620;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=MW2;
RX   PubMed=12044378; DOI=10.1016/s0140-6736(02)08713-5;
RA   Baba T., Takeuchi F., Kuroda M., Yuzawa H., Aoki K., Oguchi A., Nagai Y.,
RA   Iwama N., Asano K., Naimi T., Kuroda H., Cui L., Yamamoto K., Hiramatsu K.;
RT   "Genome and virulence determinants of high virulence community-acquired
RT   MRSA.";
RL   Lancet 359:1819-1827(2002).
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DR   EMBL; BA000033; BAB96363.1; -; Genomic_DNA.
DR   RefSeq; WP_001224187.1; NC_003923.1.
DR   AlphaFoldDB; Q79ZX9; -.
DR   SMR; Q79ZX9; -.
DR   EnsemblBacteria; BAB96363; BAB96363; BAB96363.
DR   KEGG; sam:MW2498; -.
DR   HOGENOM; CLU_069356_17_2_9; -.
DR   OMA; DAIENRQ; -.
DR   Proteomes; UP000000418; Chromosome.
DR   GO; GO:0003677; F:DNA binding; IEA:UniProtKB-KW.
DR   InterPro; IPR023772; DNA-bd_HTH_TetR-type_CS.
DR   InterPro; IPR009057; Homeobox-like_sf.
DR   InterPro; IPR001647; HTH_TetR.
DR   Pfam; PF00440; TetR_N; 1.
DR   PRINTS; PR00455; HTHTETR.
DR   SUPFAM; SSF46689; SSF46689; 1.
DR   PROSITE; PS01081; HTH_TETR_1; 1.
DR   PROSITE; PS50977; HTH_TETR_2; 1.
PE   4: Predicted;
KW   DNA-binding; Transcription; Transcription regulation.
FT   CHAIN           1..185
FT                   /note="HTH-type transcriptional regulator MW2498"
FT                   /id="PRO_0000286694"
FT   DOMAIN          6..66
FT                   /note="HTH tetR-type"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00335"
FT   DNA_BIND        29..48
FT                   /note="H-T-H motif"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00335"
SQ   SEQUENCE   185 AA;  22332 MW;  B61F5B9B2ECAD14F CRC64;
     MRKDAKENRQ RIEEIAHKLF DEEGVENISM NRIAKELGIG MGTLYRHFKD KSDLCYYVIQ
     RDLDIFITHF KQIKDDYHSN YEVMQVSLDY LLQFKIDNKA LLQCIEAGNN KLRFYQSAFY
     QELFDFYYDL FKSDDDTYTK FKTDMLLQSL STSVFAFQIE HRHISIEAYR NYLLNIYLDE
     VERND