ID   Y2524_CUPNH             Reviewed;         683 AA.
AC   P31640; Q0K8R0;
DT   01-JUL-1993, integrated into UniProtKB/Swiss-Prot.
DT   23-JAN-2007, sequence version 2.
DT   25-MAY-2022, entry version 127.
DE   RecName: Full=Uncharacterized symporter H16_A2524;
GN   OrderedLocusNames=H16_A2524;
OS   Cupriavidus necator (strain ATCC 17699 / DSM 428 / KCTC 22496 / NCIMB 10442
OS   / H16 / Stanier 337) (Ralstonia eutropha).
OC   Bacteria; Proteobacteria; Betaproteobacteria; Burkholderiales;
OC   Burkholderiaceae; Cupriavidus.
OX   NCBI_TaxID=381666;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=ATCC 17699 / DSM 428 / KCTC 22496 / NCIMB 10442 / H16 / Stanier 337;
RX   PubMed=16964242; DOI=10.1038/nbt1244;
RA   Pohlmann A., Fricke W.F., Reinecke F., Kusian B., Liesegang H., Cramm R.,
RA   Eitinger T., Ewering C., Poetter M., Schwartz E., Strittmatter A., Voss I.,
RA   Gottschalk G., Steinbuechel A., Friedrich B., Bowien B.;
RT   "Genome sequence of the bioplastic-producing 'Knallgas' bacterium Ralstonia
RT   eutropha H16.";
RL   Nat. Biotechnol. 24:1257-1262(2006).
RN   [2]
RP   NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 1-332.
RX   PubMed=1356967; DOI=10.1128/jb.174.20.6590-6599.1992;
RA   Priefert H., Steinbuechel A.;
RT   "Identification and molecular characterization of the acetyl coenzyme A
RT   synthetase gene (acoE) of Alcaligenes eutrophus.";
RL   J. Bacteriol. 174:6590-6599(1992).
CC   -!- SUBCELLULAR LOCATION: Cell membrane {ECO:0000305}; Multi-pass membrane
CC       protein {ECO:0000305}.
CC   -!- SIMILARITY: Belongs to the sodium:solute symporter (SSF) (TC 2.A.21)
CC       family. {ECO:0000305}.
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DR   EMBL; AM260479; CAJ93611.1; -; Genomic_DNA.
DR   EMBL; M97217; AAA21946.1; -; Genomic_DNA.
DR   PIR; B45736; B45736.
DR   RefSeq; WP_010814366.1; NZ_CP039287.1.
DR   AlphaFoldDB; P31640; -.
DR   SMR; P31640; -.
DR   STRING; 381666.H16_A2524; -.
DR   EnsemblBacteria; CAJ93611; CAJ93611; H16_A2524.
DR   GeneID; 57644650; -.
DR   KEGG; reh:H16_A2524; -.
DR   eggNOG; COG4147; Bacteria.
DR   HOGENOM; CLU_018808_8_2_4; -.
DR   OMA; GTTWVQM; -.
DR   OrthoDB; 278483at2; -.
DR   Proteomes; UP000008210; Chromosome 1.
DR   GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR   GO; GO:0005886; C:plasma membrane; IEA:UniProtKB-SubCell.
DR   GO; GO:0015293; F:symporter activity; IEA:UniProtKB-KW.
DR   GO; GO:0006814; P:sodium ion transport; IEA:UniProtKB-KW.
DR   Gene3D; 1.20.1730.10; -; 1.
DR   InterPro; IPR038377; Na/Glc_symporter_sf.
DR   InterPro; IPR001734; Na/solute_symporter.
DR   InterPro; IPR019899; Na/solute_symporter_VC_2705.
DR   Pfam; PF00474; SSF; 2.
DR   TIGRFAMs; TIGR03648; Na_symport_lg; 1.
DR   PROSITE; PS50283; NA_SOLUT_SYMP_3; 1.
PE   3: Inferred from homology;
KW   Cell membrane; Ion transport; Membrane; Reference proteome; Sodium;
KW   Sodium transport; Symport; Transmembrane; Transmembrane helix; Transport.
FT   CHAIN           1..683
FT                   /note="Uncharacterized symporter H16_A2524"
FT                   /id="PRO_0000105419"
FT   TRANSMEM        12..32
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        41..61
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        84..104
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        110..130
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        162..182
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        194..214
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        221..241
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        377..397
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        413..433
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        495..515
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        548..568
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        573..593
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        603..623
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        645..665
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
SQ   SEQUENCE   683 AA;  75042 MW;  DAF98B31F338D7DC CRC64;
     MPEAQSRFRR RLLLYYGLFT LGLFGFVGMM GLLEKSNADA LWLGYVFLFI TIAIYACIGL
     ICRTSDLNEY YVASRRVPAL FNGMAIAADW MSAASFIGLA GILFASGYEG LAYVMGWTGG
     YCLVAFLLAP YLRKYGGYTI PDFLAARYGN GKPGGNLPVR AIAVLAASLC SFVYLVAQIQ
     GVGLVVTRFI GVEFAVGIFF GLAGILVCSF LGGMRAVTWT QVAQYIMMIV AFLVTVSMIA
     WKHHHEALPQ LSYGTLLSQL DAREQQLERE PAEQAVREYY RQQAILLQER IARLPDSFAQ
     ERDALDARLQ DLRTRNAPLR DIKSLERERL EFPRDPAAAQ QQWNQQRADA LARSRHSLSS
     TEPYPAASEQ ERKTKRLNFV LLVFCLMVGT ASLPHILTRL YTTPSVKETR NSVAWAVFFI
     ALLYVSAPTL AALVKFEFFQ HLVGTPYAEL PQWVVQWRKV DPPVFGIRDV NGDGIVQWAE
     ILLQPDMIVL AAPEIAGLPY VISGLIAAGA LAAALSTADG LLLTIANALS HDVFYHMVDR
     QASHQRRVTT AKIVLLGVAL FASYVTSLRP GNILFLVGAA FSLAASSFFP VLVLGIFWRR
     TTAAGAVAGM AAGLGVAVYY IIVNYPFFTR MTGIFGNRWF GVDPIASGAF GVPAGFAVAI
     IVSLLTPRNA PVIDRLVSYL RKG