Y2544_DICDI
ID Y2544_DICDI Reviewed; 566 AA.
AC Q559K0; Q86KG8;
DT 14-APR-2009, integrated into UniProtKB/Swiss-Prot.
DT 14-APR-2009, sequence version 2.
DT 25-MAY-2022, entry version 87.
DE RecName: Full=Folate-like transporter DDB_G0272544;
GN ORFNames=DDB_G0272544;
OS Dictyostelium discoideum (Slime mold).
OC Eukaryota; Amoebozoa; Evosea; Eumycetozoa; Dictyostelia; Dictyosteliales;
OC Dictyosteliaceae; Dictyostelium.
OX NCBI_TaxID=44689;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=AX4;
RX PubMed=12097910; DOI=10.1038/nature00847;
RA Gloeckner G., Eichinger L., Szafranski K., Pachebat J.A., Bankier A.T.,
RA Dear P.H., Lehmann R., Baumgart C., Parra G., Abril J.F., Guigo R.,
RA Kumpf K., Tunggal B., Cox E.C., Quail M.A., Platzer M., Rosenthal A.,
RA Noegel A.A.;
RT "Sequence and analysis of chromosome 2 of Dictyostelium discoideum.";
RL Nature 418:79-85(2002).
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=AX4;
RX PubMed=15875012; DOI=10.1038/nature03481;
RA Eichinger L., Pachebat J.A., Gloeckner G., Rajandream M.A., Sucgang R.,
RA Berriman M., Song J., Olsen R., Szafranski K., Xu Q., Tunggal B.,
RA Kummerfeld S., Madera M., Konfortov B.A., Rivero F., Bankier A.T.,
RA Lehmann R., Hamlin N., Davies R., Gaudet P., Fey P., Pilcher K., Chen G.,
RA Saunders D., Sodergren E.J., Davis P., Kerhornou A., Nie X., Hall N.,
RA Anjard C., Hemphill L., Bason N., Farbrother P., Desany B., Just E.,
RA Morio T., Rost R., Churcher C.M., Cooper J., Haydock S., van Driessche N.,
RA Cronin A., Goodhead I., Muzny D.M., Mourier T., Pain A., Lu M., Harper D.,
RA Lindsay R., Hauser H., James K.D., Quiles M., Madan Babu M., Saito T.,
RA Buchrieser C., Wardroper A., Felder M., Thangavelu M., Johnson D.,
RA Knights A., Loulseged H., Mungall K.L., Oliver K., Price C., Quail M.A.,
RA Urushihara H., Hernandez J., Rabbinowitsch E., Steffen D., Sanders M.,
RA Ma J., Kohara Y., Sharp S., Simmonds M.N., Spiegler S., Tivey A.,
RA Sugano S., White B., Walker D., Woodward J.R., Winckler T., Tanaka Y.,
RA Shaulsky G., Schleicher M., Weinstock G.M., Rosenthal A., Cox E.C.,
RA Chisholm R.L., Gibbs R.A., Loomis W.F., Platzer M., Kay R.R.,
RA Williams J.G., Dear P.H., Noegel A.A., Barrell B.G., Kuspa A.;
RT "The genome of the social amoeba Dictyostelium discoideum.";
RL Nature 435:43-57(2005).
CC -!- FUNCTION: Folate transporter. {ECO:0000250}.
CC -!- SUBCELLULAR LOCATION: Membrane {ECO:0000305}; Multi-pass membrane
CC protein {ECO:0000305}.
CC -!- SIMILARITY: Belongs to the reduced folate carrier (RFC) transporter (TC
CC 2.A.48) family. {ECO:0000305}.
CC ---------------------------------------------------------------------------
CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC ---------------------------------------------------------------------------
DR EMBL; AAFI02000008; EAL71196.2; -; Genomic_DNA.
DR RefSeq; XP_645106.2; XM_640014.2.
DR AlphaFoldDB; Q559K0; -.
DR SMR; Q559K0; -.
DR STRING; 44689.DDB0302503; -.
DR TCDB; 2.A.48.1.5; the reduced folate carrier (rfc) family.
DR PaxDb; Q559K0; -.
DR EnsemblProtists; EAL71196; EAL71196; DDB_G0272544.
DR GeneID; 8618500; -.
DR KEGG; ddi:DDB_G0272544; -.
DR dictyBase; DDB_G0272544; -.
DR eggNOG; KOG3810; Eukaryota.
DR HOGENOM; CLU_481855_0_0_1; -.
DR InParanoid; Q559K0; -.
DR OMA; QDVYPFG; -.
DR PhylomeDB; Q559K0; -.
DR Reactome; R-DDI-196757; Metabolism of folate and pterines.
DR Reactome; R-DDI-196819; Vitamin B1 (thiamin) metabolism.
DR PRO; PR:Q559K0; -.
DR Proteomes; UP000002195; Chromosome 2.
DR GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR GO; GO:0005886; C:plasma membrane; IBA:GO_Central.
DR GO; GO:0005542; F:folic acid binding; IEA:UniProtKB-KW.
DR GO; GO:0090482; F:vitamin transmembrane transporter activity; IEA:InterPro.
DR GO; GO:0055085; P:transmembrane transport; IBA:GO_Central.
DR Gene3D; 1.20.1250.20; -; 1.
DR InterPro; IPR002666; Folate_carrier.
DR InterPro; IPR036259; MFS_trans_sf.
DR PANTHER; PTHR10686; PTHR10686; 1.
DR Pfam; PF01770; Folate_carrier; 2.
DR SUPFAM; SSF103473; SSF103473; 1.
PE 3: Inferred from homology;
KW Coiled coil; Folate-binding; Membrane; Reference proteome; Transmembrane;
KW Transmembrane helix; Transport.
FT CHAIN 1..566
FT /note="Folate-like transporter DDB_G0272544"
FT /id="PRO_0000369251"
FT TRANSMEM 148..168
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 171..191
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 194..214
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 226..246
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 252..272
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 304..324
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 332..352
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 364..384
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 388..408
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 420..440
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 458..478
FT /note="Helical"
FT /evidence="ECO:0000255"
FT REGION 25..46
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 526..566
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COILED 24..81
FT /evidence="ECO:0000255"
FT COILED 517..544
FT /evidence="ECO:0000255"
SQ SEQUENCE 566 AA; 64699 MW; 5922B1A85DC3EC38 CRC64;
MEDSDKENTL LLPNNKYRNQ NFIRNQDEDE NENENNDNLE NDNNKRNYIS INNYEPYKEI
DNNNNKNNNN NNIINNNNKI NFYNNLIPRI KSYFQEIKPF LKYCSFSFLF SFDPSEPYLV
DYFTNVLGIN QTIVYQEIYP YWTYSYFVFL LIFGILGEII GYKVIIIIGM VAKILTIGVL
LSTNNIIWMI LEQITEGLSY SAYTVFLAYI YFSLDTSEYQ KMACRVNAGY LVGIVSSGLL
GQLLVEQRLP LVYLLSIACG TNILALILAL GFSNYKIDQK FSLKEVISDL FGTFKNADIV
RWYIWSGIAI SIHQIVITYW QNLFLQVNDE QSWNGYISAS AYFFASFFAI IPSKLGNKIN
NIQGIILVLF GLLGGGLLVL MGFGGSTVVS ALSFIIYNCC FEFVSPIVNV QIAKKLSSRI
GVLFSFNIMV ALTIQVLVQS AVGKQFLNLD IKTQFYYYGA CLFFLSFGFA ILFGFLFLKK
KINSNSNSNS NVDVLIVNHN TQNQNSEEKK KKKELYYNAN IIDFENNNNN NNNNNNNNNN
NNNNNNNNNN NNNNNNVGIG GNDNFK
