ID   Y2560_MYCTU             Reviewed;         325 AA.
AC   P9WLA1; L0TA56; Q50738;
DT   16-APR-2014, integrated into UniProtKB/Swiss-Prot.
DT   16-APR-2014, sequence version 1.
DT   25-MAY-2022, entry version 32.
DE   RecName: Full=Uncharacterized protein Rv2560;
GN   OrderedLocusNames=Rv2560; ORFNames=MTCY9C4.08c;
OS   Mycobacterium tuberculosis (strain ATCC 25618 / H37Rv).
OC   Bacteria; Actinobacteria; Corynebacteriales; Mycobacteriaceae;
OC   Mycobacterium; Mycobacterium tuberculosis complex.
OX   NCBI_TaxID=83332;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=ATCC 25618 / H37Rv;
RX   PubMed=9634230; DOI=10.1038/31159;
RA   Cole S.T., Brosch R., Parkhill J., Garnier T., Churcher C.M., Harris D.E.,
RA   Gordon S.V., Eiglmeier K., Gas S., Barry C.E. III, Tekaia F., Badcock K.,
RA   Basham D., Brown D., Chillingworth T., Connor R., Davies R.M., Devlin K.,
RA   Feltwell T., Gentles S., Hamlin N., Holroyd S., Hornsby T., Jagels K.,
RA   Krogh A., McLean J., Moule S., Murphy L.D., Oliver S., Osborne J.,
RA   Quail M.A., Rajandream M.A., Rogers J., Rutter S., Seeger K., Skelton S.,
RA   Squares S., Squares R., Sulston J.E., Taylor K., Whitehead S.,
RA   Barrell B.G.;
RT   "Deciphering the biology of Mycobacterium tuberculosis from the complete
RT   genome sequence.";
RL   Nature 393:537-544(1998).
RN   [2]
RP   IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
RC   STRAIN=ATCC 25618 / H37Rv;
RX   PubMed=21969609; DOI=10.1074/mcp.m111.011627;
RA   Kelkar D.S., Kumar D., Kumar P., Balakrishnan L., Muthusamy B., Yadav A.K.,
RA   Shrivastava P., Marimuthu A., Anand S., Sundaram H., Kingsbury R.,
RA   Harsha H.C., Nair B., Prasad T.S., Chauhan D.S., Katoch K., Katoch V.M.,
RA   Kumar P., Chaerkady R., Ramachandran S., Dash D., Pandey A.;
RT   "Proteogenomic analysis of Mycobacterium tuberculosis by high resolution
RT   mass spectrometry.";
RL   Mol. Cell. Proteomics 10:M111.011627-M111.011627(2011).
CC   -!- SUBCELLULAR LOCATION: Cell membrane {ECO:0000305}; Multi-pass membrane
CC       protein {ECO:0000305}.
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DR   EMBL; AL123456; CCP45356.1; -; Genomic_DNA.
DR   PIR; D70728; D70728.
DR   RefSeq; NP_217076.1; NC_000962.3.
DR   RefSeq; WP_003911922.1; NZ_KK339370.1.
DR   AlphaFoldDB; P9WLA1; -.
DR   STRING; 83332.Rv2560; -.
DR   PaxDb; P9WLA1; -.
DR   DNASU; 887363; -.
DR   GeneID; 887363; -.
DR   KEGG; mtu:Rv2560; -.
DR   PATRIC; fig|83332.111.peg.2861; -.
DR   TubercuList; Rv2560; -.
DR   eggNOG; COG5473; Bacteria.
DR   OMA; GEAFGWA; -.
DR   Proteomes; UP000001584; Chromosome.
DR   GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR   GO; GO:0005886; C:plasma membrane; IDA:MTBBASE.
PE   1: Evidence at protein level;
KW   Cell membrane; Membrane; Reference proteome; Transmembrane;
KW   Transmembrane helix.
FT   CHAIN           1..325
FT                   /note="Uncharacterized protein Rv2560"
FT                   /id="PRO_0000104041"
FT   TRANSMEM        96..116
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        153..173
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        205..225
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        273..293
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   REGION          1..75
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        26..72
FT                   /note="Pro residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   325 AA;  33124 MW;  1386E137F2608F50 CRC64;
     MSQPPEHPGN PADPQGGNQG AGSYPPPGYG APPPPPGYGP PPGTYLPPGY NAPPPPPGYG
     PPPGPPPPGY PTHLQSSGFS VGDAISWSWN RFTQNAVTLV VPVLAYAVAL AAVIGATAGL
     VVALSDRATT AYTNTSGVSS ESVDITMTPA AGIVMFLGYI ALFALVLYMH AGILTGCLDI
     ADGKPVTIAT FFRPRNLGLV LVTGLLIVAV TFIGGLLCVI PGLIFGFVAQ FAVAFAVDRS
     TSPIDSVKAS IETVGSNIGG SVLSWLAQLT AVLVGELLCF VGMLIGIPVA ALIHVYTYRK
     LSGGQVVEAV RPAPPVGWPP GPQLA