ID   Y2563_MYCTU             Reviewed;         349 AA.
AC   P9WG15; L0TBL1; P65007; Q50735;
DT   16-APR-2014, integrated into UniProtKB/Swiss-Prot.
DT   16-APR-2014, sequence version 1.
DT   25-MAY-2022, entry version 35.
DE   RecName: Full=Uncharacterized ABC transporter permease Rv2563;
GN   OrderedLocusNames=Rv2563; ORFNames=MTCY9C4.05c;
OS   Mycobacterium tuberculosis (strain ATCC 25618 / H37Rv).
OC   Bacteria; Actinobacteria; Corynebacteriales; Mycobacteriaceae;
OC   Mycobacterium; Mycobacterium tuberculosis complex.
OX   NCBI_TaxID=83332;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=ATCC 25618 / H37Rv;
RX   PubMed=9634230; DOI=10.1038/31159;
RA   Cole S.T., Brosch R., Parkhill J., Garnier T., Churcher C.M., Harris D.E.,
RA   Gordon S.V., Eiglmeier K., Gas S., Barry C.E. III, Tekaia F., Badcock K.,
RA   Basham D., Brown D., Chillingworth T., Connor R., Davies R.M., Devlin K.,
RA   Feltwell T., Gentles S., Hamlin N., Holroyd S., Hornsby T., Jagels K.,
RA   Krogh A., McLean J., Moule S., Murphy L.D., Oliver S., Osborne J.,
RA   Quail M.A., Rajandream M.A., Rogers J., Rutter S., Seeger K., Skelton S.,
RA   Squares S., Squares R., Sulston J.E., Taylor K., Whitehead S.,
RA   Barrell B.G.;
RT   "Deciphering the biology of Mycobacterium tuberculosis from the complete
RT   genome sequence.";
RL   Nature 393:537-544(1998).
RN   [2]
RP   IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
RC   STRAIN=ATCC 25618 / H37Rv;
RX   PubMed=21969609; DOI=10.1074/mcp.m111.011627;
RA   Kelkar D.S., Kumar D., Kumar P., Balakrishnan L., Muthusamy B., Yadav A.K.,
RA   Shrivastava P., Marimuthu A., Anand S., Sundaram H., Kingsbury R.,
RA   Harsha H.C., Nair B., Prasad T.S., Chauhan D.S., Katoch K., Katoch V.M.,
RA   Kumar P., Chaerkady R., Ramachandran S., Dash D., Pandey A.;
RT   "Proteogenomic analysis of Mycobacterium tuberculosis by high resolution
RT   mass spectrometry.";
RL   Mol. Cell. Proteomics 10:M111.011627-M111.011627(2011).
CC   -!- SUBCELLULAR LOCATION: Cell membrane {ECO:0000305}; Multi-pass membrane
CC       protein {ECO:0000305}.
CC   -!- SIMILARITY: Belongs to the ABC-4 integral membrane protein family.
CC       {ECO:0000305}.
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DR   EMBL; AL123456; CCP45359.1; -; Genomic_DNA.
DR   PIR; G70728; G70728.
DR   RefSeq; NP_217079.1; NC_000962.3.
DR   RefSeq; WP_003413230.1; NZ_NVQJ01000023.1.
DR   AlphaFoldDB; P9WG15; -.
DR   SMR; P9WG15; -.
DR   STRING; 83332.Rv2563; -.
DR   PaxDb; P9WG15; -.
DR   GeneID; 45426565; -.
DR   GeneID; 887516; -.
DR   KEGG; mtu:Rv2563; -.
DR   TubercuList; Rv2563; -.
DR   eggNOG; COG0577; Bacteria.
DR   OMA; KMNVQTL; -.
DR   PhylomeDB; P9WG15; -.
DR   Proteomes; UP000001584; Chromosome.
DR   GO; GO:0005576; C:extracellular region; HDA:MTBBASE.
DR   GO; GO:0005887; C:integral component of plasma membrane; HDA:MTBBASE.
DR   GO; GO:0005886; C:plasma membrane; HDA:MTBBASE.
PE   1: Evidence at protein level;
KW   Cell membrane; Membrane; Reference proteome; Transmembrane;
KW   Transmembrane helix; Transport.
FT   CHAIN           1..349
FT                   /note="Uncharacterized ABC transporter permease Rv2563"
FT                   /id="PRO_0000014134"
FT   TRANSMEM        17..37
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        230..250
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        284..304
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        308..328
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   REGION          111..131
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   349 AA;  36025 MW;  694A971AC96A53F1 CRC64;
     MLFAALRDVQ WRKRRLVIAI VSTGLVFAMT LVLTGLVNGF RVEAERTVDS MGVDAFVVKA
     GAAGPFLGST PFAQIDLPQV ARAPGVLAAA PLATAPSTIR QGTSARNVTA FGAPEHGPGM
     PRVSDGRAPS TPDEVAVSST LGRNLGDDLQ VGARTLRIVG IVPESTALAK IPNIFLTTEG
     LQQLAYNGQP TISSIGIDGM PRQLPDGYQT VNRADAVSDL MRPLKVAVDA ITVVAVLLWI
     VAALIVGSVV YLSALERLRD FAVFKAIGVP TRSILAGLAL QAVVVALLAA VVGGILSLLL
     APLFPMTVVV PLSAFVALPA IATVIGLLAS VAGLRRVVAI DPALAFGGP