ID   Y2565_MYCTO             Reviewed;         583 AA.
AC   P9WIY6; L0TA62; P0A642; Q50733;
DT   16-APR-2014, integrated into UniProtKB/Swiss-Prot.
DT   16-APR-2014, sequence version 1.
DT   03-AUG-2022, entry version 32.
DE   RecName: Full=Uncharacterized NTE family protein MT2641;
GN   OrderedLocusNames=MT2641;
OS   Mycobacterium tuberculosis (strain CDC 1551 / Oshkosh).
OC   Bacteria; Actinobacteria; Corynebacteriales; Mycobacteriaceae;
OC   Mycobacterium; Mycobacterium tuberculosis complex.
OX   NCBI_TaxID=83331;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=CDC 1551 / Oshkosh;
RX   PubMed=12218036; DOI=10.1128/jb.184.19.5479-5490.2002;
RA   Fleischmann R.D., Alland D., Eisen J.A., Carpenter L., White O.,
RA   Peterson J.D., DeBoy R.T., Dodson R.J., Gwinn M.L., Haft D.H., Hickey E.K.,
RA   Kolonay J.F., Nelson W.C., Umayam L.A., Ermolaeva M.D., Salzberg S.L.,
RA   Delcher A., Utterback T.R., Weidman J.F., Khouri H.M., Gill J., Mikula A.,
RA   Bishai W., Jacobs W.R. Jr., Venter J.C., Fraser C.M.;
RT   "Whole-genome comparison of Mycobacterium tuberculosis clinical and
RT   laboratory strains.";
RL   J. Bacteriol. 184:5479-5490(2002).
CC   -!- SIMILARITY: Belongs to the NTE family. {ECO:0000305}.
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DR   EMBL; AE000516; AAK46954.1; -; Genomic_DNA.
DR   PIR; A70729; A70729.
DR   RefSeq; WP_003899379.1; NZ_KK341227.1.
DR   AlphaFoldDB; P9WIY6; -.
DR   SMR; P9WIY6; -.
DR   EnsemblBacteria; AAK46954; AAK46954; MT2641.
DR   KEGG; mtc:MT2641; -.
DR   PATRIC; fig|83331.31.peg.2848; -.
DR   HOGENOM; CLU_000960_1_3_11; -.
DR   Proteomes; UP000001020; Chromosome.
DR   GO; GO:0004622; F:lysophospholipase activity; IEA:InterPro.
DR   GO; GO:0016042; P:lipid catabolic process; IEA:UniProtKB-KW.
DR   GO; GO:0046470; P:phosphatidylcholine metabolic process; IEA:InterPro.
DR   CDD; cd00038; CAP_ED; 1.
DR   Gene3D; 2.60.120.10; -; 1.
DR   InterPro; IPR016035; Acyl_Trfase/lysoPLipase.
DR   InterPro; IPR018490; cNMP-bd-like.
DR   InterPro; IPR000595; cNMP-bd_dom.
DR   InterPro; IPR001423; LysoPLipase_patatin_CS.
DR   InterPro; IPR002641; PNPLA_dom.
DR   InterPro; IPR014710; RmlC-like_jellyroll.
DR   Pfam; PF00027; cNMP_binding; 1.
DR   Pfam; PF01734; Patatin; 1.
DR   SMART; SM00100; cNMP; 1.
DR   SUPFAM; SSF51206; SSF51206; 1.
DR   SUPFAM; SSF52151; SSF52151; 1.
DR   PROSITE; PS50042; CNMP_BINDING_3; 1.
DR   PROSITE; PS51635; PNPLA; 1.
DR   PROSITE; PS01237; UPF0028; 1.
PE   3: Inferred from homology;
KW   Hydrolase; Lipid degradation; Lipid metabolism.
FT   CHAIN           1..583
FT                   /note="Uncharacterized NTE family protein MT2641"
FT                   /id="PRO_0000427923"
FT   DOMAIN          309..469
FT                   /note="PNPLA"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU01161"
FT   MOTIF           313..318
FT                   /note="GXGXXG"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU01161"
FT   MOTIF           340..344
FT                   /note="GXSXG"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU01161"
FT   MOTIF           456..458
FT                   /note="DGA/G"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU01161"
FT   ACT_SITE        342
FT                   /note="Nucleophile"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU01161"
FT   ACT_SITE        456
FT                   /note="Proton acceptor"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU01161"
FT   BINDING         24..140
FT                   /ligand="a nucleoside 3',5'-cyclic phosphate"
FT                   /ligand_id="ChEBI:CHEBI:58464"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00060"
SQ   SEQUENCE   583 AA;  62182 MW;  BD022FAC2880AC65 CRC64;
     MTTARRRPKR RGTDARTALR NVPILADIDD EQLERLATTV ERRHVPANQW LFHAGEPADS
     IYIVDSGRFV AVAPEGHVFA EMASGDSIGD LGVIAGAARS AGVRALRDGV VWRIAAETFT
     DMLEATPLLQ SAMLRAMARM LRQSRPAKTA RRPRVIGVVS NGDTAAAPMV DAIATSLDSH
     GRTAVIAPPV ETTSAVQEYD ELVEAFSETL DRAERSNDWV LVVADRGAGD LWRHYVSAQS
     DRLVVLVDQR YPPDAVDSLA TQRPVHLITC LAEPDPSWWD RLAPVSHHPA NSDGFGALAR
     RIAGRSLGLV MAGGGARGLA HFGVYQELTE AGVVIDRFGG TSSGAIASAA FALGMDAGDA
     IAAAREFIAG SDPLDDYTIP ISALTRGGRV DRLVQGFFGN TLIEHLPRGF FSVSADMITG
     DQIIHRRGSV SGAVRASISI PGLIPPVHNG EQLLVDGGLL NNLPANVMCA DTDGEVICVD
     LRRTFVPSKG FGLLPPIVTP PGLLRRLLTG TDNALPPLQE TLLRAFDLAA STANLRELPR
     VAAIIEPDVS KIGVLNFKQI DAALEAGRMA ARAALQAQPD LVR