ID   Y2569_STAAS             Reviewed;         570 AA.
AC   Q6G5Z1;
DT   21-DEC-2004, integrated into UniProtKB/Swiss-Prot.
DT   19-JUL-2004, sequence version 1.
DT   03-AUG-2022, entry version 105.
DE   RecName: Full=Putative ABC transporter ATP-binding protein SAS2569;
DE            EC=7.-.-.-;
GN   OrderedLocusNames=SAS2569;
OS   Staphylococcus aureus (strain MSSA476).
OC   Bacteria; Firmicutes; Bacilli; Bacillales; Staphylococcaceae;
OC   Staphylococcus.
OX   NCBI_TaxID=282459;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=MSSA476;
RX   PubMed=15213324; DOI=10.1073/pnas.0402521101;
RA   Holden M.T.G., Feil E.J., Lindsay J.A., Peacock S.J., Day N.P.J.,
RA   Enright M.C., Foster T.J., Moore C.E., Hurst L., Atkin R., Barron A.,
RA   Bason N., Bentley S.D., Chillingworth C., Chillingworth T., Churcher C.,
RA   Clark L., Corton C., Cronin A., Doggett J., Dowd L., Feltwell T., Hance Z.,
RA   Harris B., Hauser H., Holroyd S., Jagels K., James K.D., Lennard N.,
RA   Line A., Mayes R., Moule S., Mungall K., Ormond D., Quail M.A.,
RA   Rabbinowitsch E., Rutherford K.M., Sanders M., Sharp S., Simmonds M.,
RA   Stevens K., Whitehead S., Barrell B.G., Spratt B.G., Parkhill J.;
RT   "Complete genomes of two clinical Staphylococcus aureus strains: evidence
RT   for the rapid evolution of virulence and drug resistance.";
RL   Proc. Natl. Acad. Sci. U.S.A. 101:9786-9791(2004).
CC   -!- FUNCTION: Probably part of an ABC transporter complex. Responsible for
CC       energy coupling to the transport system (By similarity). {ECO:0000250}.
CC   -!- SUBCELLULAR LOCATION: Cell membrane {ECO:0000250}; Peripheral membrane
CC       protein {ECO:0000250}.
CC   -!- SIMILARITY: Belongs to the ABC transporter superfamily. {ECO:0000305}.
CC   ---------------------------------------------------------------------------
CC   Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC   Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC   ---------------------------------------------------------------------------
DR   EMBL; BX571857; CAG44386.1; -; Genomic_DNA.
DR   RefSeq; WP_000138645.1; NC_002953.3.
DR   AlphaFoldDB; Q6G5Z1; -.
DR   SMR; Q6G5Z1; -.
DR   KEGG; sas:SAS2569; -.
DR   HOGENOM; CLU_000604_86_7_9; -.
DR   OMA; DPMTRLD; -.
DR   GO; GO:0005886; C:plasma membrane; IEA:UniProtKB-SubCell.
DR   GO; GO:0005524; F:ATP binding; IEA:UniProtKB-KW.
DR   GO; GO:0022857; F:transmembrane transporter activity; IEA:UniProt.
DR   CDD; cd03225; ABC_cobalt_CbiO_domain1; 2.
DR   Gene3D; 3.40.50.300; -; 2.
DR   InterPro; IPR003593; AAA+_ATPase.
DR   InterPro; IPR022216; ABC_Co_transporter.
DR   InterPro; IPR003439; ABC_transporter-like_ATP-bd.
DR   InterPro; IPR017871; ABC_transporter-like_CS.
DR   InterPro; IPR015856; ABC_transpr_CbiO/EcfA_su.
DR   InterPro; IPR027417; P-loop_NTPase.
DR   Pfam; PF00005; ABC_tran; 2.
DR   Pfam; PF12558; DUF3744; 1.
DR   SMART; SM00382; AAA; 2.
DR   SUPFAM; SSF52540; SSF52540; 2.
DR   PROSITE; PS00211; ABC_TRANSPORTER_1; 2.
DR   PROSITE; PS50893; ABC_TRANSPORTER_2; 2.
PE   3: Inferred from homology;
KW   ATP-binding; Cell membrane; Membrane; Nucleotide-binding; Repeat;
KW   Translocase; Transport.
FT   CHAIN           1..570
FT                   /note="Putative ABC transporter ATP-binding protein
FT                   SAS2569"
FT                   /id="PRO_0000092076"
FT   DOMAIN          6..247
FT                   /note="ABC transporter 1"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00434"
FT   DOMAIN          304..537
FT                   /note="ABC transporter 2"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00434"
FT   BINDING         40..47
FT                   /ligand="ATP"
FT                   /ligand_id="ChEBI:CHEBI:30616"
FT                   /ligand_label="1"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00434"
FT   BINDING         338..345
FT                   /ligand="ATP"
FT                   /ligand_id="ChEBI:CHEBI:30616"
FT                   /ligand_label="2"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00434"
SQ   SEQUENCE   570 AA;  64187 MW;  E65782B56486F1F7 CRC64;
     MTEPIISFKD FSFQYHSQAT PTLQKINVDI YPGEKVLVVG ASGSGKSTFA NCINGLIPFK
     TKGNITGELY INNQDATVSC LHDRSNVVGT VLQDTDGQFI GLTAAEDMAF LLENNCVEQD
     DMKKNVSYWA EKVGMIEHLN HRPQDLSGGQ KQRVSLGGIL IHRTPILILD EPLANLDPAT
     GHETLRLLNN IHEETKSTMI IVEHRLEESL DDTFDRVLLF KDGKIIANTT PSDLLKSSKL
     KEAGIREPLY CTALKYAEVD VESIDNLANL RDVCMSEHVK FKVKKWIDET SANNDNKYKS
     EPLLELNEVC VQYSDYSNSV LNNVQLNVYR REMLSIVGHN GAGKSTLAKA ICGFLDITGN
     IQFCNRGFNQ LSISERSEFV GYVMQNPNHM ISEKMIYDEV ALGLRARGMK ESDIKIRVEN
     VLKICGLYAF RNWPIVALSY GQKKRVTIAS VLVLNPEIII LDEPTAGQDF YHYNEIMSFL
     IELNRQGKTI IMITHDMHLL SEYSSRTVVL SKGQVVADTT PVLVLNDKKI CEIASLRQTS
     LFEMAEYIGI SEPQKLVQLF INHDRKVRRQ