ID   Y2575_MYCTU             Reviewed;         293 AA.
AC   P9WL85; L0TA92; P65019; Q50646;
DT   16-APR-2014, integrated into UniProtKB/Swiss-Prot.
DT   16-APR-2014, sequence version 1.
DT   25-MAY-2022, entry version 31.
DE   RecName: Full=Uncharacterized protein Rv2575;
GN   OrderedLocusNames=Rv2575; ORFNames=MTCY227.26c;
OS   Mycobacterium tuberculosis (strain ATCC 25618 / H37Rv).
OC   Bacteria; Actinobacteria; Corynebacteriales; Mycobacteriaceae;
OC   Mycobacterium; Mycobacterium tuberculosis complex.
OX   NCBI_TaxID=83332;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=ATCC 25618 / H37Rv;
RX   PubMed=9634230; DOI=10.1038/31159;
RA   Cole S.T., Brosch R., Parkhill J., Garnier T., Churcher C.M., Harris D.E.,
RA   Gordon S.V., Eiglmeier K., Gas S., Barry C.E. III, Tekaia F., Badcock K.,
RA   Basham D., Brown D., Chillingworth T., Connor R., Davies R.M., Devlin K.,
RA   Feltwell T., Gentles S., Hamlin N., Holroyd S., Hornsby T., Jagels K.,
RA   Krogh A., McLean J., Moule S., Murphy L.D., Oliver S., Osborne J.,
RA   Quail M.A., Rajandream M.A., Rogers J., Rutter S., Seeger K., Skelton S.,
RA   Squares S., Squares R., Sulston J.E., Taylor K., Whitehead S.,
RA   Barrell B.G.;
RT   "Deciphering the biology of Mycobacterium tuberculosis from the complete
RT   genome sequence.";
RL   Nature 393:537-544(1998).
RN   [2]
RP   IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
RC   STRAIN=ATCC 25618 / H37Rv;
RX   PubMed=21969609; DOI=10.1074/mcp.m111.011627;
RA   Kelkar D.S., Kumar D., Kumar P., Balakrishnan L., Muthusamy B., Yadav A.K.,
RA   Shrivastava P., Marimuthu A., Anand S., Sundaram H., Kingsbury R.,
RA   Harsha H.C., Nair B., Prasad T.S., Chauhan D.S., Katoch K., Katoch V.M.,
RA   Kumar P., Chaerkady R., Ramachandran S., Dash D., Pandey A.;
RT   "Proteogenomic analysis of Mycobacterium tuberculosis by high resolution
RT   mass spectrometry.";
RL   Mol. Cell. Proteomics 10:M111.011627-M111.011627(2011).
CC   -!- SUBCELLULAR LOCATION: Membrane {ECO:0000305}; Single-pass membrane
CC       protein {ECO:0000305}.
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DR   EMBL; AL123456; CCP45371.1; -; Genomic_DNA.
DR   PIR; F70724; F70724.
DR   RefSeq; NP_217091.1; NC_000962.3.
DR   RefSeq; WP_003899384.1; NZ_NVQJ01000023.1.
DR   AlphaFoldDB; P9WL85; -.
DR   STRING; 83332.Rv2575; -.
DR   PaxDb; P9WL85; -.
DR   DNASU; 888178; -.
DR   GeneID; 45426577; -.
DR   GeneID; 888178; -.
DR   KEGG; mtu:Rv2575; -.
DR   TubercuList; Rv2575; -.
DR   eggNOG; COG2321; Bacteria.
DR   OMA; QKRSQGY; -.
DR   PhylomeDB; P9WL85; -.
DR   Proteomes; UP000001584; Chromosome.
DR   GO; GO:0005576; C:extracellular region; HDA:MTBBASE.
DR   GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR   InterPro; IPR007343; Uncharacterised_pept_Zn_put.
DR   PANTHER; PTHR30168; PTHR30168; 1.
DR   Pfam; PF04228; Zn_peptidase; 1.
PE   1: Evidence at protein level;
KW   Membrane; Reference proteome; Transmembrane; Transmembrane helix.
FT   CHAIN           1..293
FT                   /note="Uncharacterized protein Rv2575"
FT                   /id="PRO_0000104056"
FT   TRANSMEM        25..45
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   REGION          1..22
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          243..265
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        1..21
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        245..265
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   293 AA;  30806 MW;  E59CDBEF58BCFB68 CRC64;
     MTFNEGVQID TSTTSTSGSG GGRRLAIGGG LGGLLVVVVA MLLGVDPGGV LSQQPLDTRD
     HVAPGFDLSQ CRTGADANRF VQCRVVATGN SVDAVWKPLL PGYTRPHMRL FSGQVGTGCG
     PASSEVGPFY CPVDKTAYFD TDFFQVLVTQ FGSSGGPFAE EYVVAHEYGH HVQNLLGVLG
     RAQQGAQGAA GSGVRTELQA DCYAGVWAYY ASTVKQESTG VPYLEPLSDK DIQDALAAAA
     AVGDDRIQQQ TTGRTNPETW THGSAAQRQK WFTVGYQTGD PNICDTFSAA DLG