ID   Y2577_MYCTU             Reviewed;         529 AA.
AC   P9WL81; L0TCU0; Q50644;
DT   16-APR-2014, integrated into UniProtKB/Swiss-Prot.
DT   16-APR-2014, sequence version 1.
DT   25-MAY-2022, entry version 36.
DE   RecName: Full=Uncharacterized protein Rv2577;
DE   Flags: Precursor;
GN   OrderedLocusNames=Rv2577; ORFNames=MTCY227.24c;
OS   Mycobacterium tuberculosis (strain ATCC 25618 / H37Rv).
OC   Bacteria; Actinobacteria; Corynebacteriales; Mycobacteriaceae;
OC   Mycobacterium; Mycobacterium tuberculosis complex.
OX   NCBI_TaxID=83332;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=ATCC 25618 / H37Rv;
RX   PubMed=9634230; DOI=10.1038/31159;
RA   Cole S.T., Brosch R., Parkhill J., Garnier T., Churcher C.M., Harris D.E.,
RA   Gordon S.V., Eiglmeier K., Gas S., Barry C.E. III, Tekaia F., Badcock K.,
RA   Basham D., Brown D., Chillingworth T., Connor R., Davies R.M., Devlin K.,
RA   Feltwell T., Gentles S., Hamlin N., Holroyd S., Hornsby T., Jagels K.,
RA   Krogh A., McLean J., Moule S., Murphy L.D., Oliver S., Osborne J.,
RA   Quail M.A., Rajandream M.A., Rogers J., Rutter S., Seeger K., Skelton S.,
RA   Squares S., Squares R., Sulston J.E., Taylor K., Whitehead S.,
RA   Barrell B.G.;
RT   "Deciphering the biology of Mycobacterium tuberculosis from the complete
RT   genome sequence.";
RL   Nature 393:537-544(1998).
CC   -!- PTM: Predicted to be exported by the Tat system. The position of the
CC       signal peptide cleavage has not been experimentally proven.
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DR   EMBL; AL123456; CCP45373.1; -; Genomic_DNA.
DR   PIR; H70724; H70724.
DR   RefSeq; NP_217093.1; NC_000962.3.
DR   RefSeq; WP_003413355.1; NZ_NVQJ01000023.1.
DR   AlphaFoldDB; P9WL81; -.
DR   SMR; P9WL81; -.
DR   STRING; 83332.Rv2577; -.
DR   PaxDb; P9WL81; -.
DR   GeneID; 45426579; -.
DR   GeneID; 888207; -.
DR   KEGG; mtu:Rv2577; -.
DR   TubercuList; Rv2577; -.
DR   eggNOG; COG1409; Bacteria.
DR   OMA; GLWYAFT; -.
DR   PhylomeDB; P9WL81; -.
DR   Proteomes; UP000001584; Chromosome.
DR   GO; GO:0005886; C:plasma membrane; HDA:MTBBASE.
DR   GO; GO:0003993; F:acid phosphatase activity; IEA:InterPro.
DR   GO; GO:0046872; F:metal ion binding; IEA:InterPro.
DR   Gene3D; 3.60.21.10; -; 1.
DR   InterPro; IPR004843; Calcineurin-like_PHP_ApaH.
DR   InterPro; IPR029052; Metallo-depent_PP-like.
DR   InterPro; IPR039331; PPA-like.
DR   InterPro; IPR008963; Purple_acid_Pase-like_N.
DR   InterPro; IPR015914; Purple_acid_Pase_N.
DR   InterPro; IPR006311; TAT_signal.
DR   PANTHER; PTHR22953; PTHR22953; 1.
DR   Pfam; PF00149; Metallophos; 1.
DR   Pfam; PF16656; Pur_ac_phosph_N; 1.
DR   SUPFAM; SSF49363; SSF49363; 1.
DR   SUPFAM; SSF56300; SSF56300; 1.
DR   PROSITE; PS51318; TAT; 1.
PE   3: Inferred from homology;
KW   Reference proteome; Signal.
FT   SIGNAL          1..52
FT                   /note="Tat-type signal"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00648"
FT   CHAIN           53..529
FT                   /note="Uncharacterized protein Rv2577"
FT                   /id="PRO_0000104060"
FT   REGION          1..20
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   529 AA;  57272 MW;  178768E48802BA2F CRC64;
     MGADLKQPQD ADSPPKGVSR RRFLTTGAAA VVGTGVGAGG TALLSSHPRG PAVWYQRGRS
     GAPPVGGLHL QFGRNASTEM VVSWHTTDTV GNPRVMLGTP TSGFGSVVVA ETRSYRDAKS
     NTEVRVNHAH LTNLTPDTDY VYAAVHDGTT PELGTARTAP SGRKPLRFTS FGDQSTPALG
     RLADGRYVSD NIGSPFAGDI TIAIERIAPL FNLINGDLCY ANLAQDRIRT WSDWFDNNTR
     SARYRPWMPA AGNHENEVGN GPIGYDAYQT YFAVPDSGSS PQLRGLWYSF TAGSVRVISL
     HNDDVCYQDG GNSYVRGYSG GEQRRWLQAE LANARRDSEI DWVVVCMHQT AISTADDNNG
     ADLGIRQEWL PLFDQYQVDL VVCGHEHHYE RSHPLRGALG TDTRTPIPVD TRSDLIDSTR
     GTVHLVIGGG GTSKPTNALL FPQPRCQVIT GVGDFDPAIR RKPSIFVLED APWSAFRDRD
     NPYGFVAFDV DPGQPGGTTS IKATYYAVTG PFGGLTVIDQ FTLTKPRGG