ID   Y2578_STAAM             Reviewed;         185 AA.
AC   Q99R60;
DT   15-MAY-2007, integrated into UniProtKB/Swiss-Prot.
DT   01-JUN-2001, sequence version 1.
DT   03-AUG-2022, entry version 114.
DE   RecName: Full=HTH-type transcriptional regulator SAV2578;
GN   OrderedLocusNames=SAV2578;
OS   Staphylococcus aureus (strain Mu50 / ATCC 700699).
OC   Bacteria; Firmicutes; Bacilli; Bacillales; Staphylococcaceae;
OC   Staphylococcus.
OX   NCBI_TaxID=158878;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=Mu50 / ATCC 700699;
RX   PubMed=11418146; DOI=10.1016/s0140-6736(00)04403-2;
RA   Kuroda M., Ohta T., Uchiyama I., Baba T., Yuzawa H., Kobayashi I., Cui L.,
RA   Oguchi A., Aoki K., Nagai Y., Lian J.-Q., Ito T., Kanamori M.,
RA   Matsumaru H., Maruyama A., Murakami H., Hosoyama A., Mizutani-Ui Y.,
RA   Takahashi N.K., Sawano T., Inoue R., Kaito C., Sekimizu K., Hirakawa H.,
RA   Kuhara S., Goto S., Yabuzaki J., Kanehisa M., Yamashita A., Oshima K.,
RA   Furuya K., Yoshino C., Shiba T., Hattori M., Ogasawara N., Hayashi H.,
RA   Hiramatsu K.;
RT   "Whole genome sequencing of meticillin-resistant Staphylococcus aureus.";
RL   Lancet 357:1225-1240(2001).
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DR   EMBL; BA000017; BAB58740.1; -; Genomic_DNA.
DR   RefSeq; WP_001224187.1; NC_002758.2.
DR   AlphaFoldDB; Q99R60; -.
DR   SMR; Q99R60; -.
DR   PaxDb; Q99R60; -.
DR   EnsemblBacteria; BAB58740; BAB58740; SAV2578.
DR   KEGG; sav:SAV2578; -.
DR   HOGENOM; CLU_069356_17_2_9; -.
DR   OMA; DAIENRQ; -.
DR   PhylomeDB; Q99R60; -.
DR   BioCyc; SAUR158878:SAV_RS14060-MON; -.
DR   Proteomes; UP000002481; Chromosome.
DR   GO; GO:0003677; F:DNA binding; IEA:UniProtKB-KW.
DR   InterPro; IPR023772; DNA-bd_HTH_TetR-type_CS.
DR   InterPro; IPR009057; Homeobox-like_sf.
DR   InterPro; IPR001647; HTH_TetR.
DR   Pfam; PF00440; TetR_N; 1.
DR   PRINTS; PR00455; HTHTETR.
DR   SUPFAM; SSF46689; SSF46689; 1.
DR   PROSITE; PS01081; HTH_TETR_1; 1.
DR   PROSITE; PS50977; HTH_TETR_2; 1.
PE   4: Predicted;
KW   DNA-binding; Transcription; Transcription regulation.
FT   CHAIN           1..185
FT                   /note="HTH-type transcriptional regulator SAV2578"
FT                   /id="PRO_0000286693"
FT   DOMAIN          6..66
FT                   /note="HTH tetR-type"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00335"
FT   DNA_BIND        29..48
FT                   /note="H-T-H motif"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00335"
SQ   SEQUENCE   185 AA;  22332 MW;  B61F5B9B2ECAD14F CRC64;
     MRKDAKENRQ RIEEIAHKLF DEEGVENISM NRIAKELGIG MGTLYRHFKD KSDLCYYVIQ
     RDLDIFITHF KQIKDDYHSN YEVMQVSLDY LLQFKIDNKA LLQCIEAGNN KLRFYQSAFY
     QELFDFYYDL FKSDDDTYTK FKTDMLLQSL STSVFAFQIE HRHISIEAYR NYLLNIYLDE
     VERND