ID   Y2585_MYCTU             Reviewed;         557 AA.
AC   P9WL77; L0TAB1; Q50636;
DT   16-APR-2014, integrated into UniProtKB/Swiss-Prot.
DT   16-APR-2014, sequence version 1.
DT   25-MAY-2022, entry version 38.
DE   RecName: Full=Uncharacterized lipoprotein Rv2585c;
DE   Flags: Precursor;
GN   OrderedLocusNames=Rv2585c; ORFNames=MTCY227.16;
OS   Mycobacterium tuberculosis (strain ATCC 25618 / H37Rv).
OC   Bacteria; Actinobacteria; Corynebacteriales; Mycobacteriaceae;
OC   Mycobacterium; Mycobacterium tuberculosis complex.
OX   NCBI_TaxID=83332;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=ATCC 25618 / H37Rv;
RX   PubMed=9634230; DOI=10.1038/31159;
RA   Cole S.T., Brosch R., Parkhill J., Garnier T., Churcher C.M., Harris D.E.,
RA   Gordon S.V., Eiglmeier K., Gas S., Barry C.E. III, Tekaia F., Badcock K.,
RA   Basham D., Brown D., Chillingworth T., Connor R., Davies R.M., Devlin K.,
RA   Feltwell T., Gentles S., Hamlin N., Holroyd S., Hornsby T., Jagels K.,
RA   Krogh A., McLean J., Moule S., Murphy L.D., Oliver S., Osborne J.,
RA   Quail M.A., Rajandream M.A., Rogers J., Rutter S., Seeger K., Skelton S.,
RA   Squares S., Squares R., Sulston J.E., Taylor K., Whitehead S.,
RA   Barrell B.G.;
RT   "Deciphering the biology of Mycobacterium tuberculosis from the complete
RT   genome sequence.";
RL   Nature 393:537-544(1998).
RN   [2]
RP   IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
RC   STRAIN=ATCC 25618 / H37Rv;
RX   PubMed=21969609; DOI=10.1074/mcp.m111.011627;
RA   Kelkar D.S., Kumar D., Kumar P., Balakrishnan L., Muthusamy B., Yadav A.K.,
RA   Shrivastava P., Marimuthu A., Anand S., Sundaram H., Kingsbury R.,
RA   Harsha H.C., Nair B., Prasad T.S., Chauhan D.S., Katoch K., Katoch V.M.,
RA   Kumar P., Chaerkady R., Ramachandran S., Dash D., Pandey A.;
RT   "Proteogenomic analysis of Mycobacterium tuberculosis by high resolution
RT   mass spectrometry.";
RL   Mol. Cell. Proteomics 10:M111.011627-M111.011627(2011).
CC   -!- SUBCELLULAR LOCATION: Cell membrane {ECO:0000305}; Lipid-anchor
CC       {ECO:0000305}.
CC   -!- SIMILARITY: To M.bovis Mb2616c and M.leprae ML0489. {ECO:0000305}.
CC   ---------------------------------------------------------------------------
CC   Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC   Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC   ---------------------------------------------------------------------------
DR   EMBL; AL123456; CCP45381.1; -; Genomic_DNA.
DR   PIR; H70725; H70725.
DR   RefSeq; NP_217101.1; NC_000962.3.
DR   RefSeq; WP_003917021.1; NZ_NVQJ01000023.1.
DR   AlphaFoldDB; P9WL77; -.
DR   SMR; P9WL77; -.
DR   STRING; 83332.Rv2585c; -.
DR   PaxDb; P9WL77; -.
DR   GeneID; 887701; -.
DR   KEGG; mtu:Rv2585c; -.
DR   TubercuList; Rv2585c; -.
DR   eggNOG; COG0747; Bacteria.
DR   OMA; WNMDRWV; -.
DR   Proteomes; UP000001584; Chromosome.
DR   GO; GO:0005829; C:cytosol; HDA:MTBBASE.
DR   GO; GO:0005576; C:extracellular region; HDA:MTBBASE.
DR   GO; GO:0030288; C:outer membrane-bounded periplasmic space; IBA:GO_Central.
DR   GO; GO:0005886; C:plasma membrane; IEA:UniProtKB-SubCell.
DR   GO; GO:1904680; F:peptide transmembrane transporter activity; IBA:GO_Central.
DR   GO; GO:0015833; P:peptide transport; IBA:GO_Central.
DR   InterPro; IPR039424; SBP_5.
DR   InterPro; IPR000914; SBP_5_dom.
DR   PANTHER; PTHR30290; PTHR30290; 1.
DR   Pfam; PF00496; SBP_bac_5; 1.
DR   PROSITE; PS51257; PROKAR_LIPOPROTEIN; 1.
PE   1: Evidence at protein level;
KW   Cell membrane; Lipoprotein; Membrane; Palmitate; Reference proteome;
KW   Signal.
FT   SIGNAL          1..30
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00303"
FT   CHAIN           31..557
FT                   /note="Uncharacterized lipoprotein Rv2585c"
FT                   /id="PRO_0000014137"
FT   LIPID           31
FT                   /note="N-palmitoyl cysteine"
FT                   /evidence="ECO:0000305"
FT   LIPID           31
FT                   /note="S-diacylglycerol cysteine"
FT                   /evidence="ECO:0000305"
SQ   SEQUENCE   557 AA;  58635 MW;  54249A870582F742 CRC64;
     MAPRRRRHTR IAGLRVVGTA TLVAATTLTA CSGSAAAQID YVVDGALVTY NTNTVIGAAS
     AGAQAFARTL TGFGYHGPDG QVVADRDFGT VSVVEGSPLI LDYQISDDAV YSDGRPVTCD
     DLVLAWAAQS GRFPGFDAAT QAGYVDIANI ECTAGQKKAR VSFIPDRSVV DHSQLFTATS
     LMPSHVIADQ LHIDVTAALL SNNVSAVEQI ARLWNSTWDL KPGRSHDEVR SRFPSSGPYK
     IESVLDDGAV VLVANDRWWG TKAITKRITV WPQGADIQDR VNNRSVDVVD VAAGSSGSLV
     TPDSYQRTDY PSAGIEQLIF APQGSLAQSR TRRALALCVP RDAIARDAGV PIANSRLSPA
     TDDALTDADG AAEARQFGRV DPAAARDALG GTPLTVRIGY GRPNARLAAT IGTIADACAP
     AGITVSDVTV DTPGPQALRD GKIDVLLAST GGATGSGSSG SCAMDAYDLH SGNGNNLSGY
     ANAQIDGIIS ALAVSADPAE RARLLAEAAP VLWDEMPTLP LYRQQRTLLM STKMYAVSRN
     PTRWGAGWNM DRWALAR