ID   Y258_BACTN              Reviewed;         663 AA.
AC   Q8AB53;
DT   23-MAY-2003, integrated into UniProtKB/Swiss-Prot.
DT   23-MAY-2003, sequence version 1.
DT   03-AUG-2022, entry version 99.
DE   RecName: Full=Putative glucosamine-6-phosphate deaminase-like protein BT_0258;
GN   OrderedLocusNames=BT_0258;
OS   Bacteroides thetaiotaomicron (strain ATCC 29148 / DSM 2079 / JCM 5827 /
OS   CCUG 10774 / NCTC 10582 / VPI-5482 / E50).
OC   Bacteria; Bacteroidetes; Bacteroidia; Bacteroidales; Bacteroidaceae;
OC   Bacteroides.
OX   NCBI_TaxID=226186;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=ATCC 29148 / DSM 2079 / JCM 5827 / CCUG 10774 / NCTC 10582 /
RC   VPI-5482 / E50;
RX   PubMed=12663928; DOI=10.1126/science.1080029;
RA   Xu J., Bjursell M.K., Himrod J., Deng S., Carmichael L.K., Chiang H.C.,
RA   Hooper L.V., Gordon J.I.;
RT   "A genomic view of the human-Bacteroides thetaiotaomicron symbiosis.";
RL   Science 299:2074-2076(2003).
CC   -!- SIMILARITY: In the N-terminal section; belongs to the
CC       glucosamine/galactosamine-6-phosphate isomerase family. NagB subfamily.
CC       {ECO:0000305}.
CC   -!- CAUTION: Lacks the two conserved aspartate and the histidine residues
CC       in position 106, 177 and 179 respectively, that are involved in the
CC       active site of the protein in orthologs; they are replaced by a
CC       tyrosine, a valine and an asparagine residue respectively.
CC       {ECO:0000305}.
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DR   EMBL; AE015928; AAO75365.1; -; Genomic_DNA.
DR   RefSeq; NP_809171.1; NC_004663.1.
DR   RefSeq; WP_008766195.1; NZ_UYXG01000025.1.
DR   AlphaFoldDB; Q8AB53; -.
DR   SMR; Q8AB53; -.
DR   STRING; 226186.BT_0258; -.
DR   PaxDb; Q8AB53; -.
DR   PRIDE; Q8AB53; -.
DR   EnsemblBacteria; AAO75365; AAO75365; BT_0258.
DR   GeneID; 60926222; -.
DR   KEGG; bth:BT_0258; -.
DR   PATRIC; fig|226186.12.peg.259; -.
DR   eggNOG; COG0363; Bacteria.
DR   HOGENOM; CLU_425041_0_0_10; -.
DR   InParanoid; Q8AB53; -.
DR   OMA; AREFWQR; -.
DR   Proteomes; UP000001414; Chromosome.
DR   GO; GO:0005737; C:cytoplasm; IEA:UniProt.
DR   GO; GO:0004342; F:glucosamine-6-phosphate deaminase activity; IEA:InterPro.
DR   GO; GO:0005975; P:carbohydrate metabolic process; IEA:InterPro.
DR   GO; GO:0006044; P:N-acetylglucosamine metabolic process; IEA:InterPro.
DR   CDD; cd01399; GlcN6P_deaminase; 1.
DR   Gene3D; 3.40.50.10320; -; 1.
DR   InterPro; IPR006148; Glc/Gal-6P_isomerase.
DR   InterPro; IPR003737; GlcNAc_PI_deacetylase-related.
DR   InterPro; IPR004547; Glucosamine6P_isomerase.
DR   InterPro; IPR018321; Glucosamine6P_isomerase_CS.
DR   InterPro; IPR024078; LmbE-like_dom_sf.
DR   InterPro; IPR037171; NagB/RpiA_transferase-like.
DR   Pfam; PF01182; Glucosamine_iso; 1.
DR   Pfam; PF02585; PIG-L; 1.
DR   SUPFAM; SSF100950; SSF100950; 1.
DR   SUPFAM; SSF102588; SSF102588; 1.
DR   PROSITE; PS01161; GLC_GALNAC_ISOMERASE; 1.
PE   3: Inferred from homology;
KW   Reference proteome.
FT   CHAIN           1..663
FT                   /note="Putative glucosamine-6-phosphate deaminase-like
FT                   protein BT_0258"
FT                   /id="PRO_0000160190"
FT   REGION          1..290
FT                   /note="Glucosamine-6-phosphate deaminase-like"
FT   ACT_SITE        184
FT                   /evidence="ECO:0000250"
SQ   SEQUENCE   663 AA;  75266 MW;  1096392F41538590 CRC64;
     MKTNLSSQIT LHRVSPRYYR PENAFEKSVL TRLEKIPTDI YESVEEGANY IACEIAQTIR
     EKQKAGRFCV LALPGGNSPS HVYSELIRMH KEEGLSFRNV IVFNMYEYYP LTADAINSNF
     NALKEMLLDH VDIDKQNIFT PDGTIAKDTI FEYCRLYEQR IESFGGIDIA LLGIGRVGNI
     AFNEPGSRLN STTRLILLDN ASRNEASKIF GTIENTPISS ITMGVSTILG AKKVYLLAWG
     ENKAAMIKEC VEGPISDTIP ASYLQTHNNA HVAIDLSASM NLTRIQRPWL VTSCEWNDKL
     IRSAIVWLCQ LTGKPILKLT NKDYNENGLS ELLALFGSAY NVNIKIFNDL QHTITGWPGG
     KPNADDTYRP ERAKPYPKRV VIFSPHPDDD VISMGGTLRR LVEQKHEVHV AYETSGNIAV
     GDEEVVRFMH FINGFNQIFN NSEDLVISEK YAEIRKFLKE KKDGDMDSRD ILTIKGLIRR
     GEARTASSYN NIPLDRVHFL DLPFYETGKI QKNPISEADV EIVRNLLREI KPHQIFVAGD
     LADPHGTHRV CTDAVFAAVD LEKEEGAKWL KDCRIWMYRG AWAEWEIENI EMAVPISPEE
     LRAKRNSILK HQSQMESAPF LGNDERLFWQ RSEDRNRGTA TLYDQLGLAS YEAMEAFVEY
     IPL