ID   Y2592_STRCO             Reviewed;         942 AA.
AC   Q9L1I4;
DT   16-MAY-2006, integrated into UniProtKB/Swiss-Prot.
DT   01-OCT-2000, sequence version 1.
DT   25-MAY-2022, entry version 88.
DE   RecName: Full=Exopolysaccharide phosphotransferase SCO2592;
DE            EC=2.7.-.-;
DE   AltName: Full=Stealth protein SCO2592;
GN   OrderedLocusNames=SCO2592; ORFNames=SCC88.03c;
OS   Streptomyces coelicolor (strain ATCC BAA-471 / A3(2) / M145).
OC   Bacteria; Actinobacteria; Streptomycetales; Streptomycetaceae;
OC   Streptomyces; Streptomyces albidoflavus group.
OX   NCBI_TaxID=100226;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=ATCC BAA-471 / A3(2) / M145;
RX   PubMed=12000953; DOI=10.1038/417141a;
RA   Bentley S.D., Chater K.F., Cerdeno-Tarraga A.-M., Challis G.L.,
RA   Thomson N.R., James K.D., Harris D.E., Quail M.A., Kieser H., Harper D.,
RA   Bateman A., Brown S., Chandra G., Chen C.W., Collins M., Cronin A.,
RA   Fraser A., Goble A., Hidalgo J., Hornsby T., Howarth S., Huang C.-H.,
RA   Kieser T., Larke L., Murphy L.D., Oliver K., O'Neil S., Rabbinowitsch E.,
RA   Rajandream M.A., Rutherford K.M., Rutter S., Seeger K., Saunders D.,
RA   Sharp S., Squares R., Squares S., Taylor K., Warren T., Wietzorrek A.,
RA   Woodward J.R., Barrell B.G., Parkhill J., Hopwood D.A.;
RT   "Complete genome sequence of the model actinomycete Streptomyces coelicolor
RT   A3(2).";
RL   Nature 417:141-147(2002).
RN   [2]
RP   IDENTIFICATION AS A STEALTH PROTEIN, AND PREDICTION OF FUNCTION.
RX   PubMed=16299590; DOI=10.1371/journal.pcbi.0010063;
RA   Sperisen P., Schmid C.D., Bucher P., Zilian O.;
RT   "Stealth proteins: in silico identification of a novel protein family
RT   rendering bacterial pathogens invisible to host immune defense.";
RL   PLoS Comput. Biol. 1:492-499(2005).
CC   -!- MISCELLANEOUS: Stealth proteins are part of a protein family that is
CC       conserved from bacteria to higher eukaryotes. Family members were first
CC       identified in microbes as proteins that help pathogens to elude the
CC       host innate immune system. Microbial stealth proteins are involved in
CC       the biosynthesis of exopolysaccharides. Stealth proteins are predicted
CC       to function as hexose-1-phosphoryltransferases.
CC   -!- SIMILARITY: Belongs to the stealth family. {ECO:0000305}.
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DR   EMBL; AL939113; CAB75373.1; -; Genomic_DNA.
DR   RefSeq; NP_626829.1; NC_003888.3.
DR   RefSeq; WP_011028443.1; NZ_VNID01000001.1.
DR   AlphaFoldDB; Q9L1I4; -.
DR   SMR; Q9L1I4; -.
DR   STRING; 100226.SCO2592; -.
DR   CAZy; GT4; Glycosyltransferase Family 4.
DR   GeneID; 1098026; -.
DR   KEGG; sco:SCO2592; -.
DR   PATRIC; fig|100226.15.peg.2638; -.
DR   eggNOG; COG0438; Bacteria.
DR   HOGENOM; CLU_311673_0_0_11; -.
DR   InParanoid; Q9L1I4; -.
DR   OMA; CTISFWD; -.
DR   PhylomeDB; Q9L1I4; -.
DR   Proteomes; UP000001973; Chromosome.
DR   GO; GO:0016757; F:glycosyltransferase activity; IEA:InterPro.
DR   GO; GO:0016772; F:transferase activity, transferring phosphorus-containing groups; IEA:InterPro.
DR   GO; GO:0000271; P:polysaccharide biosynthetic process; IEA:UniProtKB-KW.
DR   InterPro; IPR001296; Glyco_trans_1.
DR   InterPro; IPR031358; Stealth_CR1.
DR   InterPro; IPR021520; Stealth_CR2.
DR   InterPro; IPR031357; Stealth_CR3.
DR   InterPro; IPR031356; Stealth_CR4.
DR   Pfam; PF00534; Glycos_transf_1; 1.
DR   Pfam; PF17101; Stealth_CR1; 1.
DR   Pfam; PF11380; Stealth_CR2; 1.
DR   Pfam; PF17102; Stealth_CR3; 1.
DR   Pfam; PF17103; Stealth_CR4; 1.
PE   3: Inferred from homology;
KW   Exopolysaccharide synthesis; Reference proteome; Transferase.
FT   CHAIN           1..942
FT                   /note="Exopolysaccharide phosphotransferase SCO2592"
FT                   /id="PRO_0000235959"
SQ   SEQUENCE   942 AA;  105064 MW;  108B737B98A97B80 CRC64;
     MKITFLLTWG DEMGGTEQAV YTQATHLAPR HDIEVLSVFK TREQPFFSVD ERVSVRYLVD
     RTGKTERPVR ESDLTAEDCR HLAGLPSDLI SPKWEATFDA LSDVEMQRAL RTIDTDVLIT
     TSPALMSAVA DLAPSRVITI QQEHRPSQLR GGTGEPLLLR APAIDALVVL TERTKQWLEE
     SLGKAAPRLA AIPNAIPEGF RPRSSLTGKT IVMPRRLVPD KQVDHAIQAF AKALPDHPGW
     RLRIFGDGPQ MSRLRNLIQG LGLHDSVELL GPSQHMTEEW ARASLTILPS QDGEAFPLVL
     LEAFAAGVPA VAYDIVTGPA EIIRHGEDGL LVPPNDVESL AEAISRLMGD EALLRSYGEK
     AHEGSTRFAA DVIVKQWEEL FTELVSRRDD PRRMAERADR IAHRVAHGGA GRFHAAVAAD
     RTAPSSGDQR AREVVIGASD RSLVRAGGRL SEVRDDLQGS EIVQRNFETV VEALESSGIP
     YVLLRDRDDN PRRRLAVDAA EQTRVRKALA GAYEGKAVYA ELLKPRTHAP GVLLAERLEA
     VGEVAGLRVF RPVVTSTRTL RFGPAYGCDI EFWRQVPEEE GGDGQFVAPL RPSAVGPKLP
     SLTPDARTRV KDREYPTLEP LTRKLVSDIT FPVDAVYTWV DDSDPRWQER RARRRAALGL
     EAESSGDEAA RFRNRDELRY SLRSLAMFAP WIRKIYLVTD DQTPEWLNTE HEGIEVVSHR
     DIFTDQDCLP TFNSHSIESQ LHHIDGLSEQ FLYLNDDVFI GRPVGAQRFF LPNGASRFFW
     SPTTVPVGEP TEEDEGYFAA AKNNRALLEE RFGVTVANSF VHAPHPLRRS VLESIEEDFP
     ESVARTAATP MRGWQDISMV SSLHHHYGYL TGASVPSSIR CAYIDVGTYS RHPELTRLLA
     MRGHDVFCLG ESQDAEVPEH EQARIVEAFL RAYFPVKSPY ER