ID   Y2593_STAAC             Reviewed;         185 AA.
AC   Q5HCX3;
DT   15-MAY-2007, integrated into UniProtKB/Swiss-Prot.
DT   15-FEB-2005, sequence version 1.
DT   25-MAY-2022, entry version 100.
DE   RecName: Full=HTH-type transcriptional regulator SACOL2593;
GN   OrderedLocusNames=SACOL2593;
OS   Staphylococcus aureus (strain COL).
OC   Bacteria; Firmicutes; Bacilli; Bacillales; Staphylococcaceae;
OC   Staphylococcus.
OX   NCBI_TaxID=93062;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=COL;
RX   PubMed=15774886; DOI=10.1128/jb.187.7.2426-2438.2005;
RA   Gill S.R., Fouts D.E., Archer G.L., Mongodin E.F., DeBoy R.T., Ravel J.,
RA   Paulsen I.T., Kolonay J.F., Brinkac L.M., Beanan M.J., Dodson R.J.,
RA   Daugherty S.C., Madupu R., Angiuoli S.V., Durkin A.S., Haft D.H.,
RA   Vamathevan J.J., Khouri H., Utterback T.R., Lee C., Dimitrov G., Jiang L.,
RA   Qin H., Weidman J., Tran K., Kang K.H., Hance I.R., Nelson K.E.,
RA   Fraser C.M.;
RT   "Insights on evolution of virulence and resistance from the complete genome
RT   analysis of an early methicillin-resistant Staphylococcus aureus strain and
RT   a biofilm-producing methicillin-resistant Staphylococcus epidermidis
RT   strain.";
RL   J. Bacteriol. 187:2426-2438(2005).
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DR   EMBL; CP000046; AAW38594.1; -; Genomic_DNA.
DR   RefSeq; WP_001224188.1; NC_002951.2.
DR   AlphaFoldDB; Q5HCX3; -.
DR   SMR; Q5HCX3; -.
DR   EnsemblBacteria; AAW38594; AAW38594; SACOL2593.
DR   KEGG; sac:SACOL2593; -.
DR   HOGENOM; CLU_069356_17_2_9; -.
DR   OMA; DAIENRQ; -.
DR   Proteomes; UP000000530; Chromosome.
DR   GO; GO:0003677; F:DNA binding; IEA:UniProtKB-KW.
DR   InterPro; IPR023772; DNA-bd_HTH_TetR-type_CS.
DR   InterPro; IPR009057; Homeobox-like_sf.
DR   InterPro; IPR001647; HTH_TetR.
DR   Pfam; PF00440; TetR_N; 1.
DR   PRINTS; PR00455; HTHTETR.
DR   SUPFAM; SSF46689; SSF46689; 1.
DR   PROSITE; PS01081; HTH_TETR_1; 1.
DR   PROSITE; PS50977; HTH_TETR_2; 1.
PE   4: Predicted;
KW   DNA-binding; Transcription; Transcription regulation.
FT   CHAIN           1..185
FT                   /note="HTH-type transcriptional regulator SACOL2593"
FT                   /id="PRO_0000286690"
FT   DOMAIN          6..66
FT                   /note="HTH tetR-type"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00335"
FT   DNA_BIND        29..48
FT                   /note="H-T-H motif"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00335"
SQ   SEQUENCE   185 AA;  22260 MW;  B61F5B984ECAD14F CRC64;
     MRKDAKENRQ RIEEIAHKLF DEEGVENISM NRIAKELGIG MGTLYRHFKD KSDLCYYVIQ
     RDLDIFITHF KQIKDDYHSN YEVMQVSLDY LLQFKIDNKA LLQCIEAGNN KLRFYQSAFY
     QELFDFYYDL FKSDDDTYTK FKTDMLLQSL STSVFAFQIE HRHISIEAYR NYLLNIYLDE
     VGRND